摘要
胆囊癌是胆道系统最常见的恶性肿瘤,其恶性程度高,易发生远处转移。早期胆囊癌可进行根治性手术,局部晚期或转移性胆囊癌多依赖放疗和化疗,但由于胆囊癌易发生耐药且耐药机制复杂,因此深入探讨胆囊癌发生和发展、转移以及耐药的机制尤为重要。长链非编码RNA(long noncoding RNA,lncRNA)是指不编码蛋白质的长度超过200个核苷酸的非编码RNA,参与基因调控的各个环节。近年来,采用高通量测序和微阵列芯片等技术已发现胆囊癌中有许多lncRNA表达异常,其中多种表达失调的lncRNA在胆囊癌的发生和发展以及化疗耐药中发挥重要作用。本文围绕胆囊癌相关lncRNA的研究进展进行综述,以期总结lncRNA在胆囊癌发生和发展、转移以及化疗耐药中的机制,为胆囊癌的临床诊断和治疗提供新的思路。
Gallbladder carcinoma(GBC)is the most common malignant tumor in the biliary system.It is highly malignant and prone to distant metastasis.Radical surgery can be performed for early GBC.Locally advanced or metastatic GBC mostly depends on radiotherapy and chemotherapy.However,because GBC is prone to drug resistance and the mechanism of drug resistance is complicated,it is particularly important to explore the mechanism of the occurrence,development,metastasis and drug resistance of GBC.Long non-coding RNA(IncRNA)refers to non-coding RNA with a length of more than 200 nucleotides that does not encode proteins and participates in all aspects of gene regulation.In recent years,many abnormal IncrRNAs have been found in GBC by high-throughput sequencing and microarray technology.Among them,a variety of IncRNAs with dysregulated expression play an important role in the occurrence and development of GBC and chemotherapy resistance.This review focuses on the research progress in GBC-related IncRNAs,in order to summarize the mechanism of IncRNAs in the occurrence,development,metastasis and chemotherapy resistance of GBC,and provide new ideas for the clinical diagnosis and treatment of GBC.
作者
胡小强
陈炜
HU xiaoqiang;CHEN wei(Department of Biliary and Pancreatic Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200120,China;Shanghai Key Laboratory of Biliary Tract Disease Research,Shanghai 200120,China;Shanghai Research Center of Biliary Tract Disease,Shanghai 200120,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2022年第3期221-228,共8页
Tumor
关键词
胆囊癌
长链非编码RNA
肿瘤进展
耐药
Gallbladder carcinoma
Long noncoding RNA
Tumor progression
Drug resistance
