摘要
目的分析不同献血总次数的男性单采血小板献血者血常规中血小板与白细胞相关指标的变化,评估献血次数对献血者外周血液学相关指标的影响。方法选择2020年4月23日~2021年4月23日在本中心成功捐献单采血小板且献血总次数分别为初次、十的整数倍次及百次以上的448名男性自愿无偿献血者,其中十次以上的献血者年献血次数≥8次,比较献血者末次单采前外周血中PLT、PDW、MPV、P-LCR、PCT、WBC、NEUT#、LYMPH#、MONO#、EO#和BASO#指标的变化。结果总献血次数百次以上男性单采血小板献血者的WBC、PLT、PCT、NEUT#和LYMPH#相较于初次男性单采血小板献血者差异有统计学意义(P<0.01),其中WBC、PCT、NEUT#虽差异有统计学意义,但两组献血者三项指标中位数仍在正常参考值范围内,PLT则在可捐献单采血小板血液检查要求(≥150×10^(9)/L且<450×10^(9)/L)范围内。百次以上男性单采血小板献血者LYMPH#低于正常参考值发生率为86.21%,初次男性单采血小板献血者LYMPH#低于正常参考值发生率为6.37%,差异有统计学意义(P<0.01);献血次数越多的单采血小板献血者,LYMPH#水平整体显著更低;献血次数为20、30次的单采血小板献血者中LYMPH#低于正常参考值者高达46.38%,且随着献血次数的增多,LYMPH#低于正常参考值者占比逐步增高。结论多次数捐献单采血小板会导致献血者LYMPH#水平低于正常参考值,采供血机构在单采血小板献血者招募工作中应重视该现象。
Objective In this paper,we analyzed the changes of related indexes of platelet and white blood cell in the blood routine of male apheresis platelet donors with different total times of platelet donation,then evaluated the effect of donation times on the peripheral hematology related indicators.Methods 448 voluntary male blood donors were enrolled,who had successfully donated platelet in our blood center from April 232020 to April 232021(the total number of blood donations were one time,ten times,multiple times of ten,and more than one hundred times respectively,among which,the apheresis platelet donors with a total number of donations more than ten times donate platelet at least 8 times a year,)the changes of the following indicators in the peripheral blood of the donors before the last platelet donation were compareed,including PLT,PDW,MPV,P-LCR,PCT,WBC,NEUT#,LYMPH#,MONO#,EO#and BASO#.Results Compared with first-time male apheresis platelet donors,there were significant differences in WBC,PLT,PCT,NEUT#and LYMPH#among apheresis platelet donors with more than hundreds total blood donations(P<0.01).Although the WBC,PCT and NEUT were significant between the two groups#,the median of these three indicators were still within the range of normal reference values,and PLT was within the normal range required for the blood testing(≥150×10^(9)/L and<450×10^(9)/L).The incidence of LYMPH#lower than the normal reference value was 86.21%in male pheresis platelet donors who donated blood more than 100 times,while that was 6.37%in those who donated platelet for the first time,and there was a significant difference between the above two groups.The more blood donations,the lower the overall level of LYMPH#of platelet donors.Among the platelet donors who donated blood 20 and 30 times,the proportion of LYMPH#lower than the normal reference value accounted for 46.38%,and with the increase of platelet donation times,the proportion of that gradually increased.Conclusion The results indicated multiple pheresis platelet donation woul
作者
宋英伟
卞成蓉
潘雪
张晓娟
冯丽梅
张宏飞
宋丽娟
汪德清
SONG Ying-wei;BIAN Cheng-rong;PAN Xue(Department of Blood Transfusion,the First Medical Center,Chinese PLA General Hospital,Beijing 100853)
出处
《临床输血与检验》
CAS
2022年第5期610-615,共6页
Journal of Clinical Transfusion and Laboratory Medicine
基金
军队“十三五”重点项目(No.BWS16J006-02)
国家自然科学基金项目资助(No.81970167)
国家自然科学基金项目(No.81800108)资助。
关键词
多次数成分献血
男性
成分献血者
血常规
淋巴细胞
Multiple platelet
Donation male
Apheresis platelet donors
Blood routine
Lymphocyte
