摘要
中药及其有效成分在防治脑缺血再灌注损伤的过程中,通过信号传导及调节相关蛋白基因,阻断炎症级联反应和内质网应激,减少氧自由基产生,改善线粒体功能,以实现治疗脑缺血再灌注引起的神经细胞凋亡的目的,对大脑缺血性损伤发挥重要的保护作用。脑缺血再灌注损伤的防治工作取得较好的成绩,但亟须解决以下问题:①研究多属小样本、单中心,实验结果误差大;②观察指标或信号通路众多但单一、重复,未涉及多种信号通路和蛋白靶点之间的串联机制,无法深入探索作用机制;③动物模型制作及其种类的标准未统一,影响因素较多,缺乏研究的针对性;④探索性新药的临床疗效存在不确定性等。今后需进一步运用代谢组学、网络药理学等新兴学科进行临床特异性设计,加强探索信号通路、蛋白靶点在分子水平上彼此间的交互作用,并开展临床类研究,重视药物的临床转化,为防治脑血管疾病提供依据。
Chinese medicine and its active ingredients in the process of prevention and treatment of cerebral ischemia?reperfusion injury,through signaling and regulation of related protein genes,block the inflammation cascade and endoplasmic reticulum stress,reduce the production of oxygen free radicals,improve mitochondrial function To achieve the purpose of treating neuronal apoptosis caused by cerebral ischemia?reperfusion,and play an important protective role against ischemic injury of the brain.The prevention and treatment of cerebral ischemia-reperfusion injury has achieved good results,but the following problems need solving:①The researches are mostly small sample,single center,and the experimental results are large.②Observation indicators or signal pathways are numerous but single,repeated,not involving the tandem mechanism between multiple signal pathways and protein targets,it is impossible to explore the mechanism of action in depth.③The production standards of animal models and their species are not uni?form,and there are many influencing factors,lack of research specificity.④There are uncertainties in clinical efficacy of the exploratory new drugs.In the future,it is necessary to further use the emerging disciplines such as metabolomics and network pharmacology to carry out clinical specific design,strengthen the exploration of the interaction between signal pathways and protein targets at the molecular level,and carry out clinical research,paying attention to the clinical transformation of drugs to provide a basis for prevention and treatment of cerebrovascular diseases.
作者
颜凡棋
姚春栉
覃燕琼
陈燕
刘体勤
张青萍
YAN Fanqi;YAO Chunzhi;QIN Yanqiong;CHEN Yan;LIU Tiqin;ZHANG Qingping(Guangxi University of Chinese Medicine,Nanning Guangxi China 530001;The First Affiliated Hospital to Guangxi University of Chinese Medicine,Nanning Guangxi China 530023)
出处
《中医学报》
CAS
2019年第10期2108-2112,共5页
Acta Chinese Medicine
基金
广西壮族自治区临床重点专科建设项目{桂卫医发[2015]5号文}
广西中医药大学研究生创新计划资助项目(YCSY2018030)
关键词
脑缺血再灌注损伤
中药有效成分
作用靶点
研究进展
cerebral ischemia-reperfusion injury
active constituents of traditional Chinese medicine
target
research progress
