摘要
目的探讨纳洛酮与无创正压通气(NIPPV)联合应用对慢阻肺合并轻中度肺性脑病的临床应用效果。方法将100例慢阻肺合并轻中度肺性脑病患者随机分为研究组与对照组,每组各50例。对照组患者使用NIPPV治疗,研究组患者在NIPPV的基础上加用纳洛酮治疗。对比两组患者的肺通气功能、肺换气功能以及主要症状改善情况。结果研究组患者治疗后1 d和治疗后3 d的肺通气功能各项指标显著优于对照组(P<0.01);研究组患者治疗后1 d和治疗后3 d的肺换气功能各指标显著优于对照组(P<0.01);研究组患者治疗有效率显著高于对照组(P<0.05)。结论纳洛酮与NIPPV联合应用治疗慢阻肺合并轻中度肺性脑病的临床效果确切,具有临床应用价值。
Objective To evaluate the clinical efficacy of naloxone combined with Non- invasive positive pressure ventilation（ NIPPV）on chronic obstructive pulmonary disease（ COPD） patients with mild- to- moderate pulmonary encephalopathy. Methods A total of 100 COPD patients with mild- to- moderate pulmonary encephalopathy were randomly divided into study group and control group,with 50 patients in each group. Patients in the control group were treated by NIPPV. Patients in the study group were treated by naloxone combined with NIPPV. The pulmonary ventilation function,pulmonary respiratory function and cardinal symptom were compared between two groups.Results All pulmonary ventilation function index in the study group were significantly better than those in control group 1 d and 3 d after treatment（ P 〈0. 01）. All pulmonary respiratory function index in study group were significantly better than those in control group 1 d and3 d after treatment（ P 〈0. 01）. The clinical effective rate in study group was significantly higher than that in control group（ P 〈0. 05）.Conclusion The treatment of naloxone combined with NIPPV has great clinical effect on COPD patients with mild- to- moderate pulmonary encephalopathy,which makes it worth of clinical application.
出处
《黑龙江医学》
2015年第4期392-394,共3页
Heilongjiang Medical Journal
