摘要
本文研究了青海省２８个疫源县（市）镇，不同宿主分离的鼠疫菌６９０株，根据生化性状，毒力因子、毒力、大质粒分子量差异、营养型等结合地理分布可分为三个生物型：即青藏高原型、祁连山型和阿尔金山型。其中青藏高原型又根据大质粒的分布分为两个亚型。各生物型有特定的分布区域，由于主要宿主相同，各生物型之间有近缘关系。揭示了青海疫源地内鼠疫病原体生物群落结构的复杂性，遗传变异的规律性及其流行病学意义。研究表明青海各生物型菌株对人和动物的侵袭力和毒力最强，在疫源地内必须加强综合性防治措施，以控制动物鼠疫流行并严防波及人间。本研究还首次提出了以大质粒分子量差异作为本疫源地内区分鼠疫菌生物亚型的指标。
he 690 strains of Yersinia pestis isolated from various hosts and vectors from 28 counties(cities) andtownships,where were the plague natural foci in Qinghai,have been studied. Based on the combination of thestrains geographic distributions with biochemical features, virulence factors,virulence,molecular weight vari-ations among large plasmids and nuturitional requirement types, three kinds of biotypes were defined.Theywere Qinghai─Tibetan biotype that was composed of two subtypes according to the distribution of large plas-mids,Qilian Mountain and Altun mountain biotypes,respectively.The results showed that the strains owntheir specific distribution regions and close relationships among three biotypes due to the similarity of hosts.It elicitedt the complexity of composition of bacteria bio─community,regularity of genetic variations,and sig-nificance on epidemiology in Qinghai Plague foci.The results also demonstrated that the strains of all biotypesof Yersinia pestis in qinghai possessed the highest virulence to human and animals compared with that fromother foci.Moreover,systematical prophylaxsis should be strengthened in this region to control the animalplague for preventing from human plague.It was also proposed in this study that the variation of large plas-mid in molecular weight could be used as an index in determine the biological subtype of Yersinia pestis in thisplague focus.
出处
《地方病通报》
1994年第1期1-6,共6页
Endemic Diseases Bulletin
关键词
鼠
疫源地
生态型
质粒
流行病学
Plague, Natural focus, Yersinia pestis, Biotype, Plasmid, Epidemiology, Qinghai Province
