摘要
自噬是细胞清除自身异常或多余大分子和细胞器的过程,对细胞和机体维持生存是必需的。肝脏是自噬水平较高的器官,急性肝衰竭可在短时间内因各种原因导致肝细胞大量损伤而造成严重后果。在急性肝衰竭中,一些病因及机体环境会对自噬水平产生影响进而影响疾病进程,从该角度着手研究可为急性肝衰竭的预防和治疗开拓新的方向。
Autophagy is a process that cells degrade abnormal or redundant macromolecules and organelles,which is necessary for the survival of cells and the body.Liver is an organ with a high level of autophagy.Acute liver failure is a serious consequence of a large number of liver cell damage caused by various reasons in a short period.In acute liver failure,some causes and the environment will have a certain impact on autophagy and then affect the development of the disease.Studying on this perspective may be able to discover new prophylactic or treatment directions for acute liver failure.
作者
张璐懿
陈倩
石春霞
龚作炯
Zhang Luyi;Chen Qian;Shi Chunxia;Gong Zuojiong(Department of Infectious Diseases,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2022年第4期10-14,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
国家自然科学基金(82070609)。
关键词
自噬
急性肝衰竭
炎症反应
Autophagy
Acute liver failure
Inflammatory response
