摘要
目的 探讨盐酸右美托咪定联合芬太尼对前列腺电切术患者术后镇痛效果及血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的影响。方法 选取2017年5月至2019年5月鄂州市鄂钢医院收治的前列腺电切术患者100例作为研究对象,采用随机数字表法分为对照组与观察组,每组50例。对照组使用常规麻醉药物及芬太尼,观察组在对照组基础上采用盐酸右美托咪定联合麻醉,比较两组患者不同时段的生命体征、视觉模拟评分法(VAS)和Ramesay评分、IL-6、TNF-α以及不良反应发生率。结果 在手术开始时(t1)时,两组患者心率、收缩压、舒张压差异无统计学意义(P>0.05);术后6 h(t2)、术后12 h(t3)、术后48 h(t4)时刻,观察组患者心率、收缩压、舒张压均低于对照组,差异有统计学意义(P<0.05)。在t1时,两组患者VAS和Ramesay评分差异无统计学意义(P>0.05);t2、t3、t4时刻,观察组患者VAS和Ramesay评分均低于对照组(P<0.05)。麻醉诱导前,两组患者IL-6和TNF-α水平差异无统计学意义(P>0.05);手术结束时,两组患者IL-6、TNF-α水平显著上升(P<0.05),但观察组患者IL-6和TNF-α水平显著低于对照组(P<0.05)。两组患者在麻醉期间均未出现严重的不良反应。对照组不良反应发生率34.00%(17/50),观察组不良反应发生率38.00%(19/50),组间比较差异无统计学意义(χ^(2)=0.173,P=0.676)。结论 前列腺电切术患者术后镇痛使用盐酸右美托咪定联合芬太尼,对患者心率以及血压波动影响较小,镇痛效果较好,对血清炎症因子影响较小,安全性较高。
Objective To explore the effect of dexmedetomidine hydrochloride combined with fentanyl on postoperative analgesia and the levels of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in patients undergoing prostatectomy.Methods 100 cases of patients with prostate resection treated in Ezhou Egang Hospital from May 2017 to May 2019 were selected as the research objects,and were randomly divided into control group and observation group with 50 cases in each group by using the random number table method.The control group was given conventional anesthetic drugs and fentanyl,while the observation group was given dexmedetomidine hydrochloride combined anesthesia on the basis of the control group.The life status,visual simulation score and Ramesay score,IL-6,TNF-α at different periods and the incidence of adverse reactions of the two groups were compared.Results At t1,there was no significant difference in heart rate,systolic pressure and diastolic pressure between the two groups (P>0.05).At t2,t3and t4,The heart rate,systolic blood pressure and diastolic blood pressure of patients in the observation group were lower than those in the control group,and the difference was statistically significant (P<0.05).At t1,there was no significant difference in visual simulation score and Ramesay score between the two groups (P>0.05).At t2,t3and t4,VAS and Ramesay scores of patients in the observation group were lower than those in the control group (P<0.05).Before treatment,there was no significant difference in IL-6 and TNF-α levels between the two groups (P>0.05).After treatment,the levels of IL-6 and TNF-α in two groups increased significantly (P<0.05),and the levels of IL-6 and TNF-α in observation group were significantly lower than those in control group (P<0.05).There were no serious adverse reactions in the two groups during anesthesia.The incidence of adverse reactions in the control group was 34.00%(17/50),while that in the observation group was 38.00%(19/50).There was no significant difference between
作者
程赟
CHENG Yun(Operating room of Ezhou Egang hospital,Ezhou 435000,China)
出处
《中国药物经济学》
2022年第12期85-89,93,共6页
China Journal of Pharmaceutical Economics
