摘要
目的分析未见原核(0PN)来源胚胎行冻融单囊胚移植的妊娠结局及单胎新生儿结局。方法回顾性分析2016年12月至2019年12月于邯郸市中心医院生殖医学科接受IVF助孕并行冻融单囊胚移植的253个周期患者的临床资料。根据囊胚不同来源分组,分为0PN囊胚组(n=29)和双原核(2PN)囊胚组(n=224),比较两组患者的妊娠结局和新生儿结局;采用多因素线性/Logistic回归分析调整混杂因素后0PN来源囊胚对临床结局及新生儿结局的影响。结果两组患者的一般资料比较均无显著性差异(P>0.05);两组间β-HCG阳性率、临床妊娠率、早期流产率和活产率比较均无显著性差异(P>0.05);两组患者的新生儿胎龄、早产儿比例、新生儿体重、低体重儿比例、新生儿性别比例比较均无显著性差异(P>0.05)。多因素线性/Logistic回归分析结果显示,在调整了女方年龄、体质量指数(BMI)、不孕年限、基础FSH、子宫内膜厚度、不孕类型、内膜准备方案及不孕原因等混杂因素后,0PN来源囊胚不影响临床妊娠结局和新生儿结局(P>0.05)。结论在IVF周期中,当正常2PN来源胚胎数量不足时,移植0PN来源囊胚是一种安全、有价值的选择。
Objective:To evaluate the clinical pregnancy and neonatal outcomes of single frozen-thawed blastocyst transplantation from non-pronuclear(0PN)embryos.Methods:The clinical data of 253 cycles of IVF assisted pregnancy and single frozen-thawed blastocyst transplantation in the Department of Reproductive Medicine of Handan Central Hospital from December 2016 to December 2019 was analyzed retrospectively.According to the pronuclear number of blastocysts,the cycles were divided into 0PN blastocyst group(n=29)and 2PN blastocyst group(n=224).The pregnancy and neonatal outcomes were compared between the two groups.Multivariate linear/logistic regression analysis was used to analyze the effect of 0PN-derived blastocysts on clinical pregnancy outcomes and neonatal outcomes after adjusting for confounding factors.Results:There was no significant difference in general data between the two groups(P>0.05).There were no significant differences in the positive rate ofβ-HCG,clinical pregnancy rate,early abortion rate and live birth rate between the two groups(P>0.05).There were no significant differences in gestational age,proportion of premature infants,newborn weight,proportion of low weight infants and sex ratio between the two groups(P>0.05).Multivariate linear/logistic regression analysis showed that after adjusting the female age,body mass index(BMI),infertility years,basic FSH,endometrial thickness,type of infertility,endometrial preparation protocol and the causes of infertility,0PN blastocysts did not affect pregnancy outcomes and neonatal outcomes.Conclusions:In the IVF cycle,transplantation of 0PN blastocysts is a safe and valuable option when the number of normal 2PN embryos is insufficient.
作者
张卉
柴亮听
卢静
王玉红
王常燕
常文亮
景丽
ZHANG Hui;CHAI Liang-ting;LU Jing;WANG Yu-hong;WANG Chang-yan;CHANG Wen-liang;JING Li(Department of Reproductive Medicine,Handan Central Hospital,Handan 056000;Department of Clinical Laboratory,Handan First Hospital,Handan 056000)
出处
《生殖医学杂志》
CAS
2021年第8期1027-1032,共6页
Journal of Reproductive Medicine
基金
河北省卫生健康委员会科研基金(20171124)。
关键词
未见原核
冻融单囊胚移植
妊娠结局
新生儿结局
Non-pronuclear
Single frozen-thawed blastocyst transplantation
Pregnancy outcomes
Neonatal outcomes
