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耐多药肺结核病治疗方案中使用莫西沙星的临床效果 被引量:2

Clinical Effect of Moxifloxacin in Multi-drug Resistant Pulmonary Tuberculosis Treatment Plan
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摘要 目的观察并比较耐多药肺结核病治疗方案中使用左氧氟沙星与莫西沙星的临床效果。方法选取本院2017年3月至2019年4月收治的耐多药肺结核病患者64例,按随机数字表法分为对照组32例与试验组32例,两组均采用相同的基础抗结核治疗方案,即应用吡嗪酰胺、阿米卡星、丙硫异烟胺和乙胺丁醇进行治疗,在此基础上,试验组采用莫西沙星治疗,对照组采用左氧氟沙星治疗,对比两组患者的临床效果以及不良反应发生情况。结果试验组的临床治疗总有效率是96.88%,远比对照组的78.13%高(P<0.05)。对照组发生肝功能异常、胃肠道反应、白细胞减少以及皮疹等不良反应的概率是18.75%,与试验组的21.88%相比,无差异(P>0.05)。结论对耐多药肺结核病患者采用莫西沙星治疗,其临床效果要比采用左氧氟沙星的治疗效果好。 Objective To observe and compare the clinical effects of levofloxacin and moxifloxacin in the treatment of multi-drug resistant pulmonary tuberculosis.Methods Sixty-four multi-drug resistant pulmonary tuberculosis patients admitted to our hospital from March 2017 to April 2019 were selected and divided into control group(32 cases)and experimental group(32 cases)according to random number table method.Both groups should adopt the same basic anti-tuberculosis treatment scheme,pyrazinamide,amikacin,isonicotinamide and ethambutol.On this basis,the experimental group was treated with moxifloxacin while the control group was treated with levofloxacin.The clinical effects and adverse reactions of the two groups were compared.Results The total effective rate of clinical treatment in the experimental group was 96.88%,far higher than 78.13%in the control group(P<0.05).The probability of adverse reactions such as abnormal liver function,gastrointestinal reaction,leukopenia and rash occurred in the control group was 18.75%,compared with 21.88%in the experimental group,there was no difference(P>0.05).Conclusion The clinical effect of moxifloxacin is better than levofloxacin in the treatment of multi-drug resistant pulmonary tuberculosis patients.
作者 张雪元 ZHANG Xueyuan(Fuxin Infectious Disease Hospital,Fuxin 123000,China)
出处 《中国医药指南》 2021年第4期62-63,共2页 Guide of China Medicine
关键词 耐多药肺结核病 莫西沙星 左氧氟沙星 不良反应 MDR-TB Moxifloxacin Levofloxacin Adverse reaction
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