摘要
目的探讨霉菌性阴道炎患者外周血、阴道分泌物炎症指标检测变化,为患者提供临床指导。方法选取2017年1月-2018年12月来该院治疗的霉菌性阴道炎患者80例作为观察组,采用奥硝唑治疗,另外选取体检健康者40例作为对照组,检测并比较入选者治疗前和治疗后外周血和阴道分泌物肿瘤坏死因子-α(TNF-α)、白细胞介素-2 (IL-2)、白细胞介素-4(IL-4)、白细胞介素-6 (IL-6)、白细胞介素-10 (IL-10)和白细胞介素-12 (IL-12)炎症指标变化,还有CD3^+、CD4^+和CD8^+T淋巴细胞的水平变化。结果治疗前,观察组外周血和阴道分泌物中TNF-α、IL-2、IL-12、CD3^+、CD4^+和CD8^+T淋巴细胞的水平变化均明显低于对照组,IL-4、IL-6和IL-10水平变化均明显高于对照组,治疗后,观察组TNF-α、IL-2、IL-12、CD3^+、CD4^+和CD8^+T淋巴细胞的水平变化均明显高于治疗前,IL-4、IL-6和IL-10水平变化均明显低于治疗前(均P<0. 05),而观察组各指标与对照组比较,差异无统计学意义(P>0. 05)。结论霉菌性阴道炎患者外周血、阴道分泌物中TNF-α、IL-2、IL-12、CD3^+、CD4^+和CD8^+T淋巴细胞因子下调表达,IL-4、IL-6和IL-10呈上调表达,说明这些炎症指标检测与疾病发展相关。
Objective To explore the changes of inflammatory biomarkers in peripheral blood and vaginal secretion of patients with colpitis mycotica,provide clinical guidance for the patients. Methods Eighty patients with colpitis mycotica treated by ornidazole in the Fourth Hospital of Ningbo from January 2017 to December 2018 were selected as observation group,forty healthy women were selected as control group. The levels of tumor necrosis factor-α( TNF-α),interleukin-2( IL-2),interleukin-4( IL-4),interleukin-6( IL-6),interleukin-10( IL-10),interleukin-12( IL-12),CD3^+T lymphocyte,CD4^+T lymphocyte,CD8^+T lymphocyte in peripheral blood and vaginal secretion before and after treatment were detected and compared. Results Before treatment,the levels of TNF-α,IL-2,IL-12,CD3^+T lymphocyte,CD4^+T lymphocyte,and CD8^+T lymphocyte in peripheral blood and vaginal secretion in observation group were statistically significantly lower than those in control group;the levels of IL-4,IL-6,and IL-10 in observation group were statistically significantly higher than those in control group( P<0. 05). After treatment,the levels of TNF-α,IL-2,IL-12,CD3^+T lymphocyte,CD4^+T lymphocyte,and CD8^+T lymphocyte in peripheral blood and vaginal secretion in observation group were statistically significantly higher than those before treatment;the levels of IL-4,IL-6,and IL-10 were statistically significantly lower than those before treatment( P<0. 05). There was no statistically significant difference in inflammatory biomarkers between observation group and control group( P > 0. 05).Conclusion The levels of TNF-α,IL-2,IL-12,CD3^+T lymphocyte,CD4^+T lymphocyte,and CD8^+T lymphocyte in peripheral blood and vaginal secretion of patients with colpitis mycotica decrease,while the levels of IL-4,IL-6,and IL-10 increase,which indicates that these inflammatory biomarkers are correlated with the progression of the disease.
作者
沈琰
曹姗
SHEN Yan;CAO Shan(Department of Clinical Laboratory,the Fourth Hospital of Ningbo,Ningbo,Zhejiang 315700,China)
出处
《中国妇幼保健》
CAS
2020年第1期110-113,共4页
Maternal and Child Health Care of China
关键词
霉菌性阴道炎
外周血
阴道分泌物
T淋巴细胞
炎症指标
Colpitis mycotica
Peripheral blood
Vaginal secretion
T lymphocyte
Inflammatory biomarker
