摘要
目的了解本地区261例新发现艾滋病病毒(HIV)感染者病毒在体内复制水平。方法采用反转录荧光定量聚合酶链反应试验(RT-PCR)测定新发现HIV感染者病毒载量,并对不同性别、不同感染途径及不同年龄新发现HIV感染者病毒载量进行比较。结果261例新发现HIV感染者病毒载量范围为:1.73~7.00Log/mL,均值为4.67Log/mL,其中病毒载量<3Log/mL 7例,占2.68%,3~5Log/mL 165例,占63.22%,>5Log/mL89例,占34.1%。另外,不同性别新发现HIV感染者病毒载量差异有统计学意义(P<0.05);异性传播途径与男男性行为传播途径、母婴传播途径的新发现HIV感染者病毒载量差异均有统计学意义(P<0.05);<18岁与≥18岁的各年龄组新发现HIV感染者病毒载量差异均有统计学意义(P<0.05)。结论本地区新发现HIV感染者病毒载量偏高,应尽早开展抗病毒治疗,不仅有利于降低HIV感染者发病和死亡风险,同时亦可降低HIV传播的风险。
Objective To investigate the level of virus replication in 261 newly detected HIV infected patients in Zhongnan hospital.Methods The viral load was measured through RT-PCR with plasma from the HIV infected,and then comparison was made by gender,infection route and ages.Results The range of viral load from 261 newly detected HIV infected patients was 1.73-7.00 Log/mL,with the mean value of 4.67 Log/mL.The range of viral load from less than 3 Log/mL,3-5 Log/mL to more than 5 Log/mL was 7(2.68%),165(63.22%)and 89(34.10%),respectively.There were significant differences in viral load among HIV infected patients of different genders(P<0.05),between heterosexual,homosexual and mother-to-child transmission(P<0.05);and in different age groups between less than 18 years old and more than or equal to 18 years old(P<0.05).Conclusion The newly detected HIV infected patients have a high level of virus replication,and antiviral treatment should be initiated as soon as possible,in order to reduce the risk of HIV morbidity and mortality,as well as the risk of HIV transmission.
作者
严亚军
桂希恩
冯玲
杨蓉蓉
YAN Yajun;GUI Xien;FENG Ling;YANG Rongrong(Department of Infectious Diseases,Zhongnan Hospital,Wuhan University,Wuhan 430071,Hubei,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2019年第10期1019-1021,共3页
Chinese Journal of Aids & STD
