摘要
目的探讨应用尼可地尔对急性心肌梗死病人再灌注性心律失常发生率及心肌损伤标志物肌钙蛋白I(cTnI)的影响。方法选取延安大学附属医院心脑血管病专科医院2013年1月—2015年1月收治的64例急性ST段抬高型心肌梗死病人作为研究对象,将其随机均分为观察组和对照组,每组32例。对照组采用常规溶栓治疗,观察组在常规溶栓基础上给予尼可地尔治疗,比较两组病人急性心肌梗死再灌注性心律失常的发生率,分别观察两组病人治疗后4h、12h、24h心肌损伤标志物cTnI水平变化。结果治疗后,观察组病人再灌注心律失常发生率为40.6%,对照组病人再灌注心律失常发生率为53.1%,两组比较差异有统计学意义(P<0.05);观察组在治疗后4h、12h、24h的cTnI水平均明显低于对照组,差异有统计学意义(P<0.05)。结论应用尼可地尔对急性心肌梗死病人进行治疗,不仅明显改善病人再灌注性心律失常发生率,而且可以降低心肌损伤标志物cTnI。
Objective To investigate the effects of nicorandil on the incidence of reperfusion arrhythmia and troponin I (cTn I)in pa- tients with acute myocardial infarction (AMI).Methods Sixty four patients with acute ST segment elevation myocardial infarction (STEMI)were selected as the research object in our hospital from January 2013 to January 2015.The patients were randomly divided into two groups:control group(n = 32)treated with routine thrombolysis treatment,and treatment group(n = 32)treated with nic- orandil.The incidence of reperfusion arrhythmia and the change of cTn I levels after treatment at 4 hours,12 hours and 24 hours were observed.Results After treatment,the incidence of reperfusion arrhythmia was 40.6% in treatment group and 53.1% in control group (P <0.05).The levels of cTn I in treatment group were lower than that in control group after treatment at 4 hours,12 hours,24 hours (P <0.05).Conclusion Nicorandil can decrease the level of cTn I and the incidence of reperfusion arrhythmia in patients with AMI.
作者
赵莉
白延平
Zhao Li;Bai Yanping(Specialist Hospital of Cardiovascular and Cerebrovascular Diseases,Affiliated Hospital of Yan'an University,Yanan 716000,Shaanxi,China)
出处
《中西医结合心脑血管病杂志》
2016年第14期1590-1592,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
