期刊文献+

关注质子泵抑制剂的不良反应与合理用药 被引量:33

Adverse reactions and rational use of proton pump inhibitors
下载PDF
导出
摘要 质子泵抑制剂(proton pump inhibitor,PPI)是临床治疗酸相关性疾病,如胃食管反流、消化性溃疡、卓-艾综合征、上消化道出血以及与其他药物联用根除幽门螺杆菌的重要的常用药物.这类药物短期使用可引起过敏反应、血液系统、消化系统和神经系统等不良反应,长期使用可引发一系列新的安全性问题,如增加感染风险,使营养成分缺乏而引起维生素B12缺乏、骨折、低镁血症,促进萎缩性胃炎的发生或发展,引起间质性肾炎,致显微镜结肠炎,增加严重的皮肤过敏反应的风险等.然而,世界范围内PPI的超适应证用药或滥用情况非常普遍.因此,国家有关管理部门、临床医生、药师都应关注PPI的临床合理用药问题. Proton pump inhibitors (PPIs) are a class of important drugs for treating acid related diseases, such as gastroesophageal reflux diseases (GERD), peptic ulcer, Zollinger-Ellison syndrome, and upper gastrointestinal bleeding. When combined with other drugs, PPIs can be used for the eradication of Helicobacter pylori. Short-term use of PPIs can cause allergic reactions, adverse reactions of the hematologic system, the digestive system and the nervous system and so on. Long-term use of PPIs can cause a series of new safety issues, such as increased risk of infection, vitamin B12 deficiency caused by the lack of nutrients, fractures, hypomagnesemia, occurrence or development of atrophic gastritis, interstitial nephritis, microscopic colitis, increased risk of serious skin allergy and so on. However, inappropriate use and off-label use of PPIs, and even abuse of PPIs are very common worldwide. Therefore, clinical rational use of PPIs should be emphasized among the relevant national administration departments, clinicians and pharmacists.
作者 雷招宝
出处 《世界华人消化杂志》 CAS 2016年第23期3468-3475,共8页 World Chinese Journal of Digestology
关键词 质子泵抑制剂 不良反应 临床合理用药 Proton pump inhibitors Adverse reactions Rational use
  • 相关文献

参考文献62

  • 1Shin JM, Kim N. Pharmacokinetics and pharmacodynamics of the proton pump inhibitors. J Neurogastroenterol Motil. 2013;19:25-35. 被引量:1
  • 2Thomson AB, Sauve MD, Kassam N, Kamitakahara H. Safety of the long-term use of proton pump inhibitors. World J Gastroenterol. 2010;16:2323-2330. 被引量:1
  • 3陈维娜,张小晋.质子泵抑制剂与酸反跳[J].世界华人消化杂志,2010,18(28):2951-2955. 被引量:7
  • 4L?drup AB, Reimer C, Bytzer P. Systematic review: symptoms of rebound acid hypersecretion following proton pump inhibitor treatment. Scand J Gastroenterol. 2013;48:515-522. 被引量:1
  • 5Teixeira MZ. Rebound acid hypersecretion after withdrawal of gastric acid suppressing drugs: new evidence of similitude. Homeopathy. 2011;100:148-156. 被引量:1
  • 6Barrett TD, Lagaud G, Wagaman P, Freedman JM, Yan W, Andries L, Rizzolio MC, Morton MF, Shankley NP. The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. Br J Pharmacol. 2012;166:1684-1693. 被引量:1
  • 7Niv Y. Gradual cessation of proton pump inhibitor (PPI) treatment may prevent rebound acid secretion, measured by the alkaline tide method, in dyspepsia and reflux patients. Med Hypotheses. 2011;77:451-452. 被引量:1
  • 8Famularo G, Gasbarrone L, Minisola G. Hypomagnesemia and proton-pump inhibitors. Expert Opin Drug Saf. 2013;12:709-716. 被引量:1
  • 9Cheungpasitporn W, Thongprayoon C, Kittanamongkolchai W, Srivali N, Edmonds PJ, Ungprasert P, O'Corragain OA, Korpaisarn S, Erickson SB. Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies. Ren Fail. 2015;37:1237-1241. 被引量:1
  • 10Tamura T, Sakaeda T, Kadoyama K, Okuno Y. Omeprazole- and esomeprazole-associated hypomagnesaemia: data mining of the public version of the FDA Adverse Event Reporting System. Int J Med Sci. 2012;9:322-326. 被引量:1

二级参考文献52

共引文献38

同被引文献296

引证文献33

二级引证文献184

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部