摘要
质子泵抑制剂(proton pump inhibitor,PPI)是临床治疗酸相关性疾病,如胃食管反流、消化性溃疡、卓-艾综合征、上消化道出血以及与其他药物联用根除幽门螺杆菌的重要的常用药物.这类药物短期使用可引起过敏反应、血液系统、消化系统和神经系统等不良反应,长期使用可引发一系列新的安全性问题,如增加感染风险,使营养成分缺乏而引起维生素B12缺乏、骨折、低镁血症,促进萎缩性胃炎的发生或发展,引起间质性肾炎,致显微镜结肠炎,增加严重的皮肤过敏反应的风险等.然而,世界范围内PPI的超适应证用药或滥用情况非常普遍.因此,国家有关管理部门、临床医生、药师都应关注PPI的临床合理用药问题.
Proton pump inhibitors (PPIs) are a class of important drugs for treating acid related diseases, such as gastroesophageal reflux diseases (GERD), peptic ulcer, Zollinger-Ellison syndrome, and upper gastrointestinal bleeding. When combined with other drugs, PPIs can be used for the eradication of Helicobacter pylori. Short-term use of PPIs can cause allergic reactions, adverse reactions of the hematologic system, the digestive system and the nervous system and so on. Long-term use of PPIs can cause a series of new safety issues, such as increased risk of infection, vitamin B12 deficiency caused by the lack of nutrients, fractures, hypomagnesemia, occurrence or development of atrophic gastritis, interstitial nephritis, microscopic colitis, increased risk of serious skin allergy and so on. However, inappropriate use and off-label use of PPIs, and even abuse of PPIs are very common worldwide. Therefore, clinical rational use of PPIs should be emphasized among the relevant national administration departments, clinicians and pharmacists.
出处
《世界华人消化杂志》
CAS
2016年第23期3468-3475,共8页
World Chinese Journal of Digestology