摘要
目的探讨辅助生殖技术中与受精失败相关因素分析以及早期补救ICSI的临床应用价值。方法回顾性分析2010年10月至2013年10月在本院实施的297个早期补救ICSI病例,根据补行ICSI的卵母细胞的比例分为全补救组(99个周期)和部分补救组(198个周期),比较补救组和IVF正常受精组临床用药、胚胎质量以及妊娠结局。结果 (1)补救组Gn起始剂量[(3 101.89±1 390.95)U]和促排总量[(223.11±81.67)U]显著高于IVF正常受精组[(2 426.22±1 050.04)U、(192.84±61.90)U]和部分补救组[(2 373.11±910.03)U]、[(183.52±67.62)U](P<0.05),平均获卵数、MII卵数显著降低(P<0.05);(2)补救ICSI增加受精率,异常受精率无显著性增加(P>0.05);(3)全补救组妊娠率、种植率降低(P<0.05),但优胚率和活婴率无显著性差异(P>0.05)。结论在短时受精基础上实施早期补救ICSI有助于增加胚胎利用率,降低无胚胎移植风险,改善临床妊娠结局。
Objective： To analyze the factors related to fertilization failure in ART,and clinical application value of early rescue ICSI. Methods： The data of 297 early rescue ICSI cycles in our hospital from Oct 2010 to Oct 2013 were retrospectively analyzed. The cycles were divided into complete rescue group（99 cycles） and partial rescue group（198 cycles） according to the ratio of rescue oocytes with ICSI. The clinical usage of drugs,embryo quality and pregnancy outcome were compared between the two groups. Results： The starting dose [（3101.89±1390.95）U vs. （2426.22± 1050.04）U vs. （2373.11±910.03） U ] and total doses [（223.11± 81. 67） U vs. （192.84±61.90）U vs. （183.52±67.62） U）] of gonadotropin （Gn） were significantly higher in the complete rescue group than those in IVF normal fertilization group and the partial rescue group（P〈0.05）. Average number of oocytes and MII rate was significantly lower in the complete rescue group than that in IVF normal fertilization group and the partial rescue group （P 〈 0.05 ）. The normal fertilization rate was significantly increased （P 〈0.05）, but the abnormal fertilization rate was not significantly different in the early rescue ICSI group（P〈0.05）. The pregnancy rate and implantation rate were significantly decreased in the complete rescue group（P〈0.05）, but the high quality embryo rate and the live birth rate were not significantly different（P〈0.05）. Conclusions： Using the early rescue ICSI on the basis of short-term fertilization was helpful to increase the utilization rate o{ embryo,reduce the risk of no embryo to transfer,and improve the clinical pregnancy outcome.
出处
《生殖医学杂志》
CAS
2016年第7期619-622,共4页
Journal of Reproductive Medicine
基金
甘肃省卫生行业科研计划资助项目(GSWSKY-2014-30)
兰州大学第一医院院内青年基金(ldyyynqn201011)
