摘要
目的：了解不孕不育女性泌尿生殖道支原体属感染及药敏情况，以指导临床合理用药。方法选取2010年1月－2013年12月就诊于妇产科的1862例不孕不育女性患者为试验组，另选同期行健康体检的1800名女性志愿者为对照组，两组患者均采用上海奥普生物医药有限公司生产的支原体属培养鉴定药敏试剂盒，用液体培养的方法分离鉴定解脲脲支原体（Uu）和人支原体（Mh），并行药敏试验。结果对照组1862例患者宫颈分泌物支原体培养阳性有715例，阳性率为38．4％，其中单纯U U阳性检出最多，且支原体属感染患者年龄集中在25～40岁；与对照组相比，不孕不育女性单纯Uu感染率、单纯Mh感染率和Uu＋Mh混合感染率均显著增高，差异有统计学意义（P＜0．05）；试验组对米诺环素、多西环素、交沙霉素耐药性低，对罗红霉素、阿奇霉素、喹诺酮类药物耐药性高，且四环素类抗菌药物在Uu＋Mh混合感染中耐药率显著上升。结论不孕不育女性患者支原体属感染率较高，且大多数为育龄期妇女，对交沙霉素、米诺环素和多西环素敏感度高，可作为治疗支原体属感染的首选药物。
OBJECTIVE To understand the prevalence of Mycoplasma infections in genitourinary tracts of the infer‐tility patients and investigate the drug susceptibility so as to guide the reasonable clinical use of antibiotics . METHODS A total of 1 862 female infertility patients who were treated in the department of gynecology and ob‐stetrics from Jan 2010 to Dec 2013 were chosen as the experimental group ,meanwhile ,1 800 female volunteers who underwent physical examination were set as the control group .Both groups adopted the Mycoplasma culture and identification drug susceptibility kit manufactured by Shanghai Biological Pharmaceutical Co .,LTD .The Ure‐aplasma urealyticum （Uu） and Mycoplasma hominis （Mh） were isolated and identified by using liquid culture method ,and the drug susceptibility testing was performed .RESULTS Of 1 862 patients in the control group ,715 were cultured positive for Mycoplasma in cervical secretions ,with the positive rate of 38 .4% ,and the positive rate of single Uu was the highest ;the patients aged between 25 and 40 years old were dominant among the patients with Mycoplasma infections .The incidence of single Uu infection ,single Mh infection ,or mixed Uu plus Mh in‐fections was significantly higher in the female infertility patients than in the participants of the control group（P〈0 .05） .The drug resistance rates of the Mycoplasma isolated from the experimental group to minocycline ,doxy‐cycline ,and josamycin were low ,while the drug resistance rates to roxithromycin ,azithromycin ,and quinolones were high ,and the drug resistance rate of the Uu plus Mh causing mixed infections to tetracycline was significant‐ly increased .CONCLUSION The incidence of Mycoplasmainfections is high in the female infertility patients ,most of whom are at childbearing age .The Mycoplasma is highly susceptible to josamycin ,minocycline ,and doxycyc‐line ,which can be used as the preferred antibiotics for treatment of the Mycoplasma infections .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第10期2379-2381,共3页
Chinese Journal of Nosocomiology
基金
湖北省科技厅科研基金资助项目(A14301)
关键词
女性生殖道
不孕症
支原体属
感染
耐药性
Female genital tract
Infertility
Mycoplasma
Infection
Drug resistance
