摘要
目的分析缺血性脑卒中后抑郁患者应用尼麦角林、帕罗西汀联合认知干预治疗后疗效。方法采用随机平行对照法将我院119例缺血性脑卒中后抑郁患者分组,对照组59例应用帕罗西汀联合认知干预治疗,观察组60例增加尼麦角林,对比两组患者治疗后疗效、炎症因子、抑郁状态等变化。结果观察组总有效率90.00%高于对照组76.27%,TNF-α、IL-23、L-6水平及HAMD评分均低于对照组,NE、5-HT、NGF、BDNF水平均高于对照组(P<0.05)。结论帕罗西汀、尼麦角林联合认知干预有效改善缺血性脑卒中后抑郁患者炎症状态,消除抑郁情绪,效果显著。
Objective To study the efficacy of nigeroline,paroxetine and cognitive intervention on depression in patients with post ischemic stroke. Methods A total of 119 depression patients with post ischemic stroke depression were enrolled in our hospital. The control group(n=59)was treated with paroxetine combined with cognitive intervention. The observation group(n=60)was treated with paroxetine,cognitive intervention and nigeroline. The therapeutic effect,the level of serum inflammatory factors,NE,5-HT,NGF and BDNF in two groups was compared. Results The total effective rate of the observation group(90.00%)was higher than that of the control group(76.27%). The levels of serum TNF-α,IL-23,L-6 and HAMD were lower than those of the control group. The levels of serum NE,5-HT,NGF and BDNF were higher than those of the control group.(P<0.05). Conclusion The combination of paroxetine,nigeroline and cognitive intervention is effective in improving depression and the inflammatory state in patients with post ischemic stroke.
作者
樊润润
胡俊祥
郝永茂
马明明
FAN Runrun;HU Junxiang;HAO Yongmao(Department of Neurology,Third People's Hospital of Anyang,Anyang 455000,China)
出处
《国际精神病学杂志》
2018年第6期1081-1083,共3页
Journal Of International Psychiatry
关键词
尼麦角林
帕罗西汀
认知干预
卒中后抑郁
Nigralin
Paroxetine
Cognitive intervention
Post-stroke depression
