摘要
聚蛋白多糖酶 (aggrecanase)是新发现的降解软骨组织重要成分聚蛋白多糖 (aggrecan)的金属蛋白酶 ,是治疗关节炎的新靶点 .Aggrecanase的发现使得关节炎的治疗有望取得新的突破 ,为能从根本上治疗和预防关节炎提供了基础 .综述了aggrecanase从克隆到对其性质的研究 。
Aggrecan degradation is an important factor in the erosion of articular cartilage in arthritis. Aggrecanase is a newly cloned enzyme which degrades the core protein of aggrecan between the Glu(373) and Ala(374), a site different from the matrix metalloproteinases cleavage site, Asn(341) similar to Phe(342). The discovery of aggrecanase and searching for its inhibitors will accelerate the development of therapeutic agents for arthritis.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第5期654-657,共4页
Progress In Biochemistry and Biophysics
