摘要
目的了解北京市男男性行为（MSM）人群HIV及梅毒感染状况，探讨两者之间的相关性。方法对北京市艾滋病哨点监测MSM人群600例进行HIV及梅毒实验室检测。用ELISA方法对所有研究对象样本进行HIV初筛，初筛阳性者用免疫印迹方法进行确认；梅毒检测采用快速血浆反应素环状卡片试验（RPR）与梅毒螺旋体明胶凝集试验（TPPA）两种方法同时进行，TPPA阳性者即视为梅毒感染者（包括既往感染与现症感染）；符合条件的HIV阳性血清还接受HIV一1BED捕获酶联法（BED方法）检测并计算HIV在此人群中的发病率；对MSM人群HIV及梅毒感染状况进行统计学相关性分析。结果MSM人群600例，HIV阳性49例，阳性率8．17％；HIV新近感染14例，发病率为4．68％。HIV感染者表现出外地户籍比重大、学历层次相对较高的特点。梅毒RPR与TPPA均阳性51例（8．5％），感染率（含既往感染）为18．5％（111／600）。结论北京市哨点监测MSM人群HIV感染率及发病率、梅毒感染率均维持在较高水平；HIV感染与梅毒感染有显著相关性。
Objective To determine the prevalence of and correlations between HIV infection and syphilis among men who have sex with men （MSM） in Beijing. Methods Totally, 600 MSM collected from sentinel surveillance sites for AIDS in Beijing were recruited in this study, and underwent screening tests for HIV infection and syphilis. Enzyme-linked immunosorbent assay （ELISA） was used for the primary screening for HIV infection, and Western blot for its confirmation. Both nontreponemal test （rapid plasma regain （RPR） assay） and treponemal test （Treponema pallidum particle agglutination assay, TPPA） were performed to detect syphilis, and only those with a reactive TPPA result were defined as having syphilis （including past infection）. Specimens confirmed as HIV-1 positive were further tested with BED-capture enzyme immunoassay （CEIA） to find recent HIV-1 infection, and the incidence of HIV infection was then calculated. The correlation between syphilis and HIV infection was statistically analyzed. Results Of the 600 MSM, 49 （8.17%） had HIV infection, including 14 cases of recent infection, with the incidence rate of HIV infection being 4.68%; 51 were positive for both RPR and TPPA tests with the infection rate （including past infection） being 18.5% （111/600）. People without a Beijing household registration and those with high education levels accounted for a large proportion of HIV-infected MSM. Conclusions The prevalence and incidence of HIV infection as well as prevalence of syphilis maintain at a relatively high level in MSM in Beijing. HIV infection is markedly correlated with syphilis in MSM population.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2014年第5期349-350,共2页
Chinese Journal of Dermatology
关键词
同性恋
男性
HIV感染
梅毒
Homosexuality, male
HIV infections
Syphilis
