摘要
目的探讨医院泌尿生殖道炎症患者支原体属感染特点及药物敏感现状,为临床抗菌药物治疗提供参考依据。方法采用解脲脲支原体(Uu)和人支原体(Mh)培养鉴定药敏试剂盒,对948例患者进行支原体属检测和药物敏感性分析。结果支原体属培养总阳性率为64.9%,其中单纯Uu感染率为66.3%,Uu合并Mh感染率为28.5%,单纯Mh感染率为5.2%;单纯Uu感染时,女性感染率46.0%与男性的25.4%相比,差异有统计学意义(P<0.05);单纯Uu、Mh感染及混合感染对多西环素、交沙霉素和米诺环素3种抗菌药物的敏感性最强,敏感率均>68.6%;单纯Uu感染与Uu、Mh混合感染相比,前者对克拉霉素和阿奇霉素的敏感率分别为90.0%、92.2%,明显强于后者,差异有统计学意义(P<0.01),而后者对乙酰螺旋霉素、罗红霉素、环丙沙星、氧氟沙星、左氧氟沙星、克拉霉素、阿奇霉素抗菌药物的耐药率均>60.0%,则明显强于前者,差异有统计学意义(P<0.01)。结论医院泌尿生殖道炎症患者以Uu感染为主,女性单纯Uu感染阳性率明显高于男性;治疗Uu、Mh及二者合并感染时应首选多西环素、交沙霉素和米诺环素,对单纯Uu感染还可考虑使用克拉霉素和阿奇霉素;为提高治疗效果及降低耐药性,应参考药敏结果合理选用抗菌药物。
OBJECTIVE To investigate the characteristics of Mycoplasma infections in patients with urogenital inflammation and the current status of drug susceptibility so as to provide guidance for the clinical drug therapy. METHODS By means of the culture and identification of drug susceptibility kit for Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh）, the detection of Mycoplasma in 948 patients and the drug susceptibility testing were performed. RESULTS The total positive rate of the culture of Mycoplasma was 64.9 %, the incidence rate of single Uu infection was 66.3%, the mixed infection of Uu and Mh 28.5%, single Mh infection 5.2%; the inci-dence rate of single Uu infection in the female patients was 46.0%, significantly higher than 25.4% of the male patients, the difference was statistically significant （P〈0.05）. The single Uu, Mh, and mixed Uu and Mh were most susceptible to deoxycycline, josamycin, and minocycline, with the drug susceptibility rates more than 68.6% ; as compared with the single Uu and the mixed Uu and Mh, the drug susceptibility rates of the former to clarithromycin and azithromycin were respectively 90.0% and 92.2%, significantly higher than those of the later （P〈0.05）, the differences were statistically significant, and the drug resistance rates of the later to acetylspira-mycin, roxithromycin, ciprofloxacin, ofloxaein, levofloxacin, clarithromyein, and azithromycin were over 60.0 %, significantly higher than that of the former, the difference was statistically significant （P〈0.01）. CONCLUSION Uu is the predominant pathogen causing infection in the patients with urogenital inflammation, and the incidence rate of Uu infection is significantly higher in the female patients than in the male patients. Deoxyeycline,josamycin and minocycline should be taken as preferred treatment for Uu infection, Mh infection, or mixed infections of Uu and Mh; clarithromycin and azithromycin can be considered for the treatment of single Uu infection. To reasonably use antibiotics based
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第23期5886-5888,共3页
Chinese Journal of Nosocomiology
基金
南京市科委应用技术研究与开发基金项目(201201086)
