摘要
自1981年上海报告了我国首例由肠道病毒71型(human enterovirus 71,EV71)引起的手足口病(hand-foot-and-mouth disease,HFMD)以来,该病在我国各地陆续散发和暴发。2008年3月,安徽阜阳暴发了主要由EV71引起的HFMD疫情,导致22例患者死亡和3 023例患者入院[1]。同年5月,我国卫生部将其纳入法定报告管理的丙类传染病。此后,HFMD疫情在我国呈上升趋势。
Epidemics of hand, foot and mouth disease （HFMD） in China was first reported in 1981. The major causative agents are coxsackie virus A16 （CoxA16） and enterovirus 71 （EV71）. However, some infre- quent pathogens causing HFMD outbreaks were reported increasingly in the past few years, indicating the trend changes of HFMD epidemic trend. The current prevalent CoxA16 and EVT1 stains will be substituted po- tentially by other serotypes or genotypes of human enteroviruses （HEVs）, or will co-circulate with other strains in the future. In this review, we summarize recent findings in the epidemiology of HFMD including the immune deficiency of young children, development of vaccines, the changing pathogen spectrum and the influ- encing factors of HFMD transmission. We also discuss strategies for the prevention and control of HFMD in China.
出处
《中国病毒病杂志》
CAS
2013年第2期81-84,共4页
Chinese Journal of Viral Diseases
基金
国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10004213-005)
关键词
手足口病
肠道病毒
病原谱
预防
Hand, foot and mouth disease
Human enterovirus
Pathogen spectrum
Prevention
