摘要
目的:优选盐酸青藤碱聚乙烯醇(SM-PVA)微胶囊的制备工艺,并考察其表征及体外释放性能。方法:以载药量为指标,选取乳化剂用量、搅拌速度、戊二醛体积分数及油相环己烷用量为考察因素,采用W/O/W复乳界面聚合法制备SM-PVA微胶囊,通过正交试验优选SM-PVA微胶囊的制备工艺;采用紫外分光光度法测定载药量,扫描电镜观察SM-PVA微胶囊形貌,粒径分析仪表征胶囊粒径分布情况,同时考察SM-PVA微胶囊的体外释放性能。结果:优选的制备工艺为乳化剂用量7%,搅拌速度600 r.min-1,戊二醛用量25%,环己烷10 mL,载药量6.23%;制备的SM-PVA微胶囊平均粒径约16μm,呈均匀分散、表面光滑的球形。制得的SM-PVA微胶囊在模拟胃液和肠液中都表现出较好的缓释作用。结论:SM-PVA微胶囊可成为中药盐酸青藤碱的一种新型给药系统。
Objective： To optimization preparation technology of sinomenine hydrochloride-polyvinyl alcohol （SM-PVA） microcapsules, and investigate its characterization and in vitro release performance. Method： With drug loading as index, the amount of emulsifier, stirring speed, volume fraction of glutaraldehyde and dosage of cyclohexane （oil phase） were chosen as factor, SM-PVA microcapsules was prepared byW/O/W multiple emulsion interfacial polymerization method, preparation technology of SM-PVA microcapsules was optimized by orthogonal test; drug loading was determined by UV spectrophotometric, morphology of SM-PVA microcapsules was scanned by electron microscopy, particle size of SM-PVA microcapsules was charactered by particle size analysis instrument, and in vitro release performance was investigated. Result： Optimum preparation technology was： 7% emulsifier, stirring speed 600 r · min^-1, volume fraction of glutaraldehyde 10 roLand 25% cyclohexane, drug loading 6.23%; Average particle size of SM-PVA microcapsules 16 Ixm, it showed uniform dispersion and smooth surface of spherical. These prepared SM-PVA microcapsules showed good sustained release in simulated gastric and intestinal fluid. Conclusion： system of sinomenine hydrochloride from Chinese materia SM-PVA microcapsules could be a novel drug delivery medica.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第24期49-52,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
盐酸青藤碱
聚乙烯醇
微胶囊
药物释放
sinomenine hydrochloride
polyvinyl alcohol
microcapsules
drug release
