摘要
目的:了解连云港市第一人民医院药品不良反应(ADR)发生的特点及规律,为合理用药提供参考。方法:对我院收集的194例ADR报告,分别就患者基本情况、药品信息、ADR发生时间、累及器官和(或)系统及临床表现、给药途径、ADR报告类型等方面进行回顾性分析。结果:194例ADR报告中,共涉及药品97种,60岁以上人群所占比例最大,有80例(占41.24%);男性(113例)多于女性(81例);有既往药物过敏史的患者12例(占6.19%);抗病原微生物药引起的ADR最为多见,为27种,占28.13%,其次为中药制剂17种,占17.71%;静脉滴注较其他给药途径更易发生ADR(166例,占84.69%);ADR临床表现以皮肤及其附件损害发生率为最高(90例,占42.65%);严重ADR有8例。结论:抗病原微生物药、中药制剂是ADR监测的重点药物,临床应加强ADR宣传、培训和监测工作,提高合理用药水平,减少药源性疾病的发生。
OBJECTIVE：To investigate the characteristics and regularity of the adverse drug reactions（ADRs） occurred in Lianyungang First People＇s Hospital and to promote clinical rational use of drugs.METHODS： A total of 194 ADR cases collected from our hospital were retrospectively analyzed in respect of general information of patients,drug information,time to ADR onset,organs and（or） systems involved in ADR and clinical manifestations,routes of administration and types of ADR reports etc.RESULTS： Of the 194 ADR cases,97 drugs were involved;patients aged over 60 occupied great proportion（80 cases,41.24%）,and the ADRs were more often seen in males（113 cases） than in females（81 cases）;12 cases（6.19%） had the history of drug allergy;the ADRs were mostly induced by antimicrobial drugs（27 drugs,28.13%）,followed by the traditional Chinese medicine（17 drugs,17.71%）;the ADR were more likely caused by intravenous injections（166 cases,84.69%）;the main types of ADR were lesions of skin and its appendages（42.65%）.There were 8 severe ADR cases.CONCLUSION： Emphasis should be laid to antimicrobial drugs and traditional Chinese medicine in ADR monitoring.The propaganda,training and monitoring on ADR should be strengthened to promote rational use of drugs and reduce the incidence of drug-induced disease.
出处
《中国医院用药评价与分析》
2012年第4期353-356,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
分析
监测
宣传培训
合理用药
Adverse drug reactions
Analysis
Monitoring
Propaganda and training
Rational use of drugs
