摘要
Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.
Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease （HFMD）. The etiological characteristics of Coxsackie A virus type 16 （CA16） are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains＇ biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5＇ non-coding region of the viral genome and the VP1 structural region se- quence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their patho- genicity.
基金
supported by the National Basic Research Program of China (Grant No. 2011CB504903)
the National Natural Science Foundation of China (Grant No. 81171573)
the Important National Science & Technology Specific Projects (Grant No. 2009ZX10004-308)
the General Program of Applied Basic Research Programs Commission, Foundation of Yunnan Province (Grant No. 2011FB116)
