摘要
目的采用短回波时间(TE)氢质子磁共振波谱(1H-MRS)提高对脑内脱髓鞘假瘤和星形细胞瘤鉴别诊断的准确性。资料与方法19例脑内脱髓鞘假瘤,其中11例经手术证实,8例经临床证实;经手术证实的23例星形细胞瘤(其中WHOⅡ级8例,WHOⅢ-Ⅳ级15例),均行常规MRI和单体素短TE1H-MRS检查,分析短TE 1H-MRS检查中病灶的β,γ-谷氨酸复合物(Glx)/肌酸(Cr)值,结果与病灶病理诊断或临床诊断结果进行相关分析。结果脑内脱髓鞘假瘤组病灶区平均β,γ-Glx/Cr值为0.6205±0.15050;星形细胞瘤组病灶区的平均β,γ-Glx/Cr值为0.3048±0.09563,两者之间差异有统计学意义(P<0.05)。结论脑内脱髓鞘假瘤组病灶区的β,γ-Glx/Cr值明显高于星形细胞瘤组,短TE 1H-MRS中β,γ-Glx峰的升高可以作为鉴别脑内脱髓鞘假瘤和星形细胞瘤的补充手段,据此有助于提高鉴别脑内脱髓鞘假瘤与星形细胞瘤的准确性。
Objective To evaluate the value of short echo time（TE）proton magnetic resonance spectroscopy（1H MRS）in differential diagnosing tmefactive demyelinating lesions（TDLs）and astrocytomas.Materials and Methods 42 cases were collected in this study.Of the 42 patients,23 patients with pathologically proved astrocytoma（7 WHO grade Ⅱ and 16 WHO grade Ⅲ-Ⅳ）and 19 patients with TDLs（11 cases pathologically proved and 8 cases clinically proved with TDLs）.Single voxel spectra at TE 35 ms（short TE）was used in all cases.Peak heights of creatine（Cr）and glutamate（Glu）/glutamine（Gln）（β,γ-Glx）were measured,then β,γ-Glx/Cr ratios of corresponding regions in TDLs and astrocytoma were compared to pathological and clinic results.Results The mean ratio β,γ-Glx/Cr was 0.6205±0.15050 in TDLs group and 0.3048±0.09563 in astrocytoma group.The meanβ,γ-Glx/Cr ratio in TDLs was significantly higher than that of astrocytoma statistically（P0.05）.Conclusion The ratios of β,γ-Glx/Cr at short TE provide valuable information to discriminate between TDLs and astrocytomas.
出处
《临床放射学杂志》
CSCD
北大核心
2011年第4期456-459,共4页
Journal of Clinical Radiology
关键词
磁共振成像
波谱学
短回波时间
脱髓鞘假瘤
星形细胞瘤
Magnetic resonance imaging Spectroscopy Short echo time Tumefactive demyelinating lesions Astrocytoma
