摘要
消化道吸收营养物质经跨细胞或旁细胞途径.物质通过肠细胞膜的方式有主动转运（载体介导）、被动转运（扩散、渗透、滤过）和入、出胞.正常情况下,肠道上皮屏障吸收营养物质,而将有害物质隔离在体外（肠腔）.细胞间连接通常分为封闭连接（也称紧密连接,tight junction）、锚定连接（肌动蛋白纤维介导的黏合带、黏着斑,中间纤维介导的桥粒、半桥粒）及通讯连接（间隙连接、化学突触）3类.
After a series of studies, we found that the intestinal permeability was increased, tight junction protein （zonula occluden-1 ） obviously decreased and redistributed, accompanied by an increase in expression of myosin light chain （MLC） phosphorylation in severely burned rats. After using inhibitor of MLC kinase （ ML-9 2mg/kg） or of Rho-associated kinase （Y-27632 2mg/kg）, above-mentioned changes could be alleviated. Therefore, to regulate the MLC phosphorylation of tight junction protein and perijunctional actin-myosin ring may be one of the key links to lessen the intestinal epithelium permeability after burn injury.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2010年第5期334-335,共2页
Chinese Journal of Burns
关键词
烧伤
紧密连接
肠上皮通透性
Burns
Tight junction
Intestinal epithelium permeability
