摘要
目的总结分析缺血性视神经病变的发病特征、风险因素及预后，为该病的防治提供依据。方法回顾性系列病例研究。回顾性分析96例临床确诊的非动脉炎性前部缺血性视神经病变（NAION）患者的详尽临床资料，包括神经眼科检查及影像学、实验室检查。对基线特征、入院检查异常指标、视力恢复及视野损害进行均数、百分比等描述性特征的分析。结果患者平均发病年龄为（50．9±8．9）岁，年龄中位数50．0岁；男性占68．8％；患者中高血压、糖尿病和血脂异常的比例分别为34．4％（33／96）、29．2％（28／96）和59．4％（57／96）；44．4％患者出院时视力提高≥3行。结论NAION的发病年龄较低；男性比例高于女性；代谢综合征是常见的异常因素。脑白质病变、心肌缺血与NAION的关系密切。视野损害以水平及弓形缺损为主。NAION视力可有一定程度的恢复，但远期预后不良。加强早期干预是疾病防治重点。
Objective To evaluate the demographic, risk factors and clinical characteristics of nonarteritic anterior isehemic optic neuropathy （NAION） and provide clinical guidance for this blindness disease. Methods Retrospective study was used to investigate the data, which consists of 96 NAION consecutive patients in neurology department of our hospital from 2005 to 2008. Results The average age of NAION patients is 50. 90± 8.88 years （range, 34-78 years） and the median is 50 y. About 68.8% of patients are male. The prevalence of hypertension, diabetes mellitus and abnormal lipid level is 34.4% （ 33/ 96） ,29. 2% （ 21/96 ） and 59.4% （ 57/93 ） respectively, The predominant patterns of visual field loss are altitudinal and acurate defects. Visual acuity was improved （ change of ≥3 lines ） in 44.4% of patients. Conclusions The age of onset in NAION is relatively early in life, compared with cerebral vascular disease, and male seems to have a high incidence. The most common risk factor is metabolic syndrome. Subcortical and periventricular white matter lesions and myocardial ischemia might associate with NAION. Visual acuity showed improvement in some patients, but the long outcome is poor.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2009年第12期1064-1067,共4页
Chinese Journal of Ophthalmology
关键词
视神经病变
缺血性
视神经
视敏度
视野
回顾性研究
Optic neuropathy, ischemic
Optic nerve
Visual acuity
Visual fields
Retrospective studies
