摘要
目的研究观察腰椎创伤骨折围术期TNF-α、IL-6及IL-10的变化规律。方法选择腰椎创伤骨折并不完全截瘫、有绝对手术指征且准备行腰椎切开减压Rss内固定术的患者30例,均分别于骨折的第2天、第8天(手术后的第2天)、第13天(手术后的第7天)及第16天(手术后的第10天)的清晨空腹静脉采血;骨折的第6天(手术当天),术毕静脉采血。所有血液样本均由专人及时送免疫实验室,专人检测。结果(1)TNF-α于2d开始升高,分别与13、16d比较差异均有统计学意义,而与8d比较差异无统计学意义;TNF-α于6d最高,分别与2、8、13、16d比较,差异均有统计学意义。TNF-α于13d恢复正常。(2)IL-6和IL-10仅在6d显著升高,分别与2、8、13、16d比较,差异均有统计学意义,余均正常。结论TNF-α于骨折的第2天开始增高,术毕达到高峰;IL-6和IL-10均因手术本身的创伤出现一过性的增高。
Objective To evaluate the influence of TNF-α,IL-6 and IL-10 in perioperative period of the lumbar closed fracture. Methods Thirty patients suffered from lumbar closed fracture were not used the anti-coagulation drugs and prepared for open reduction and internal fixation,were taken venous blood with empty stomach on 2d, 8d, 13d 16d early morning,and right after operation on 6d. All the blood samples of TNF-α,IL-6 and IL-10 were detected by the special messengers. Results （1）TNF-α began to increase on 2d,there was significant difference compared with that on l gd and 16d, there was no significant difference compared with that on 8d;TNF-α was highest on 6d,there was significant difference compared with 2d,8d, 13d and 16d,TNF-α returned normal on 13d. （2）IL-6 and IL-10 were increased only on 6d,there were significant differences compared with that on 2d,8d, 13d and 16d,which in the other time was normal. Conclusion TNF-α increased on 2d,and reached to high peak after operation;IL-6 and IL- 10 had a transient rise due to operative trauma.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第22期2847-2848,2850,共3页
Chongqing medicine
基金
广东省佛山市科技局课题基金资助项目(200608005)
