摘要
本实验利用甲基紫精(PQ)诱导的金黄地鼠郏囊急性炎症损害模型,设计、选择超氧化物歧化酶(SOD)防治该模型损害的给药方案,包括给药途径、给药剂量以及给药次数、间隔时间等方面的内容。结果最佳给药方案为:于造模前、后1.5h在地鼠须囊粘膜下注入0.1ml2.5%SOD溶液各1次。SOD最佳给药方案的确定,有利于在合理、节约用药的前提下,获得尽量满意的疗效。
In the present study, the administration scheme of superoxide dismutase (SOD) againstparaquat-induced inflanmation in hamster oral mucosa was designed and selected. The optimal administration scheme of SOD was that 0.1ml 2. 5% SOD solution was injected into the hamster cheek pouch1. 5 h before and the same duration after the establishmant of animal model.
出处
《临床口腔医学杂志》
1997年第4期195-196,共2页
Journal of Clinical Stomatology
基金
国家教委博士点专项基金
关键词
超氧化物歧化酶
口腔粘膜
炎症
给药方案
Superoxide dismutase, Oral mucosa, Inflammation, Administration scheme