摘要
目的探讨获得性纯巨核细胞再生障碍性血小板减少性紫癜(AATP)的临床特点。方法对18例AATP患者的临床资料进行回顾性分析。以同一时期特发性血小板减少性紫癜(ITP)112例为对照组,对两组患者巨核细胞(MK)、血小板(PLT)计数、平均血小板容积(MPV)及血小板相关免疫球蛋白G(PAIgG)进行测定。结果MK总数AATP组明显减少甚至缺如,ITP组明显增多,两组比较差异有统计学意义[(0.8±1.5)vs(195.0±47.3),P<0.01]。AATP组在MPV正常范围,ITP组大于正常[(7.1±2.4)vs(14.5±3,8),P<0.05]。初诊时PLT计数两组差异无统计学意义(P>0.05)。PAIgG阳性率AATP组55.6%,ITP组83,0%,差异有统计学意义(P<0.01)。结论AATP是临床上少见的以巨核细胞再生障碍伴血小板减少为特征的出血性疾病,与ITP有本质区别。AATP在治疗上存在一定难度,在常规糖皮质激素治疗的基础上加用康力龙及环孢素A能获得一定疗效。
Objective To cxplore the clinical feature of acquired pure amegakdryocytic rhrombocytopenic purpura（AATP）. Methods 18 patients were analyzed retrospectively. And 112 patients with ITP in the same term were to be control group. Each group＇ s megakaryocytic （ MK ）, ptatelet （PLT） count, mean platelet volume （ MPV ） and platelct associated immunoglobulin G（PAlgG） were tested. Results The MK total number of AATP group was obvious decreased or even absent ,while the ITP group was increased[ （0.8 ±1.5） vs （ 195.0 ± 47.3 ）, P 〈 0.01 ]. The MPV of ITP group was much larger than which of AATP group [ （7.1 ± 2.4） vs （14.5 ± 3.8） ,P〈 0.05]. There was on significant deviation of dw diagnosis PLT count in the two groups（ P 〉0.05） . About the PAlgG posi- tive rare, AATP group was 55.6 % while ITP group was 83 % （ P 〈 0.01 ）. Conclusions AATP is a kind of infrequent hemorrhagic disease and it is characterized by MK aregeneratory accompanied with PLT decrease. It is essential difference from ITP. It has some difficulty , in the treatment of AATP. There will be some curative effect to treat it by conventional glucocorticoid combined with stanozolol and cyclosporin A.
出处
《中国基层医药》
CAS
2007年第11期1793-1795,共3页
Chinese Journal of Primary Medicine and Pharmacy
