摘要
目的探讨强直性脊柱炎(ankylosing spondylitis,AS)患者血清基质金属蛋白酶-3(MMP-3),TNF-α,IL-15,CRP水平及意义。方法采用双抗体夹心酶联免疫吸附试验(ELISA)测定45例AS患者和31例健康对照组的血清MMP-3、白细胞介素15(IL-15)、肿瘤坏死因子α(TNF-α)及C-反应蛋白(CRP)水平,比较各个指标在AS组与对照组之间的差异,并分析AS组患者各指标间的相关性。结果血清MMP-3,TNF-α,CRP水平在AS组患者显著高于健康对照组(P<0.001),IL-15水平两组比较也有显著性差异(P<0.05);在AS组仅有MMP-3与IL-15之间存在相关性。结论MMP-3和IL-15在AS发病机制中起着重要作用,可以作为评估AS病情的二个有价值的血清学指标。
Objective To investigate the significance of MMP-3 , TNF-α, IL-15 and CRP in patients with ankylosing spondylitis （AS）. Methods MMP-3,TNF-α,IL-15 and CRP serum levels were tested by sandwich ELISA in 45 patients with AS and 31 healthy controls. These results were compared with each other. Results Significantly increased serum level of MMP-3,TNF-α and CRP were found in AS patients as compared to that in healthy controls （P〈0. 001） ;serum level of IL-15 was significantly higher than that in healthy controls（P〈0. 05） ,only MMP-3 and IL-15 correlated with each other in AS patients. Conclusion It may be considered that MMP-3 and IL-15 might play a certain role in occurrence of AS, MMP-3 and IL-15 are potentially useful serum marker of AS disease activity.
出处
《现代检验医学杂志》
CAS
2007年第5期55-57,共3页
Journal of Modern Laboratory Medicine
