摘要
目的研究草酸铂(OXA)、氟尿嘧啶(5-FU)及亚叶酸钙(CF)联合化疗对晚期胃癌的临床疗效及其毒副作用。方法对26例晚期胃癌患者采用OXA130mg/m2静脉滴注2hdl,CF200mg/m2静脉滴注2hdl-5,5-FU300mg/m2静脉滴注4hdl-5、3周为1周期,对照组25例治疗方案采用顺铂(DDP),和氟尿嘧啶,3周为1周期,均连用3周期后评定疗效,按WHO标准进行疗效评定。结果试验组共治疗26例,PR13例,SD8例,PD5例,有效率为50%,对照组有效为28%,不良反应主要为感觉神经毒性,胃肠道反应,血液毒性轻微。结论OXA+5+FU+CF是治疗晚期胃癌安全有效的方案。
[Objective] To evaluate the efficacy and adverse effects of Oxaliplatin combined with 5-Fluorouracil （5-FU）ffolinic acid（FA） treatment of patients with advanced stomach cancer. [Methods] 26 patients with advanced stomach cancer OXA 130 mg/m^2 iv infusion for 2 h dl, CF 200 mg/m^2 iv infusion for 2 h, dl-d5, 5-FU 300 mg/m^2 iv infusion for 4 h, dl-d5, repited every 3 weeks. Tumor assessment was done after 3 cycles. [Results] 26 patients with PR 13 cases, SD 8 cases, PD 5 cases were studied. The overall response rate was 50%. The overall response rate of the control was 28%. The main adverse effect was neurosensory toxicity. [Conclusion] It is safe and effective to use Oxaliplatin combined with -5FU/FA treatment to patients with advanced stomach cancer.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第17期2626-2628,共3页
China Journal of Modern Medicine
