摘要
目的探讨乙型肝炎患者血清IL-6、IL-8、TNF-α含量与肝损程度及HBVDNA含量的相关性。方法107例乙型肝炎患者均做肝穿确定肝组织损害程度,检测血清IL-6、IL-8、TNF-α水平及HBVDNA含量。结果血清中IL-6、IL-8、TNF-α水平与HBVDNA含量呈正相关,随肝损程度加重,血清的IL-6、IL-8、TNF-α含量随之增加。结论乙型肝炎患者血清IL-6、IL-8、TNF-α水平与乙型肝炎肝脏损伤程度密切相关,是判定疗效和预后的重要指标。
[Objective] To probe the relation between different damages of liver tissue in patients and quantities of IL-6, IL-8, TNF-αn serum with hepatitis B. [Methods] The quantities of IL-6, IL-8, TNF-α were detected by ELISA; the DNA of virus was detected by amplisensor PCR assay system; the damages of liver tissue was detected by pathololgy. The statistics were tested. [Results] The quantitis of IL-6, IL-8, TNF-α and virus in serum were in- creased in patients with hepatitis B than that in control （P 〈0.01）. [Conalusion] All findings implied that IL-6, IL- 8 and TNF-α serum levels were related to the phases of hepatitis B and it reflected the extent of hepatocyte inflammation. So it can be used as an index to value the therapeutic effectiveness and to judge the patients prognosis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第3期395-397,共3页
China Journal of Modern Medicine
