摘要
目的观察参苓白术散在临床防治直肠放射性损伤方面的效果。方法将96例妇科肿瘤(子宫颈癌78例、子宫内膜癌18例)随机分成两组,一组为中药加放疗组(观察组,49例),另一组为单纯放疗组(对照组,47例)。两组外照射1.8～2.0Gy/次,5次/周,5～6周,总剂量48～50Gy。后装治疗宫颈癌总剂量42～49Gy,6～7周完成;子宫内膜癌总剂量10～15Gy,1～2周完成。观察组从放疗始第1天至放疗结束服用参苓白术散加减,共服用35～38剂。比较观察两组直肠放射性损伤发生情况。结果放疗1年后行纤维结肠镜检查结果显示,观察组共发生15例,其中Ⅰ度为10例,Ⅱ度为3例,Ⅲ度为2例;对照组共发生47例,其中Ⅰ度为24例,Ⅱ度为14例,Ⅲ度为9例。两组比较差异有统计学意义(P<0.01)。结论中药参苓白术散有防治直肠放射性损伤的功效。
Objective To study the effect of traditional Chinese herbal medicine—Shenlingbaishusan in preventing and treating colon and rectum radiation reactions. Methods Ninty-six patients with female pelvic tumor(cervical and endometrial cancer) were randomly divided into two groups: radiotherapy (RT) alone group(47 patients) and RT+Shenlingbaishusan group(49 patients). RT in both groups,being similar, 1.8-2.0?Gy/per fraction, five fractions/per week, to a total dose of 48-50?Gy/5-6weeks to the whole pelvis by external irradiation plus brachytherapy: to a total dose of 42-49?Gy/6-7weeks for cervix carcinoma, and 10-15?Gy/1-2weeks for endometrial cancer. Results All patients have been were followed for more than one year after radiotherapy. The incidence of acute and late colon and rectum radiation reactions. was :15 patients in the RT+Shenlingbaishusan group: gradeⅠ10 patients, Grade Ⅱ 3 patients, grade Ⅲ 2 patients incontrast to the 47 patients in the RT group: grade Ⅰ24 patients, grade Ⅱ 14 patients and grade Ⅲ 9 patients(P<0.01). Conclusions The traditional Chinese medicine-Shenlingbaishusan is effective in preventing and treating colon and rectum radiation reactions during pelvic tumor radiotherapy.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2005年第4期304-306,共3页
Chinese Journal of Radiation Oncology
基金
深圳市科技局资助课题(200104069)
关键词
参苓白术散
直肠放射性损伤
中草药
子宫肿瘤
Uterine neoplasms/radiotherapy
Radioenteritis
Chinese herbal medicine
Radiation-protective agents
