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新诊断2型糖尿病患者动脉粥样斑块的发病情况及危险因素研究 被引量:6

Artery atheromatous plaques in newly diagnosed type 2 diabetic patients and its correlated risk factors
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摘要 目的探讨新诊断2型糖尿病合并动脉粥样斑块的发病情况及影响因素。方法对538例新诊断的2型糖尿病患者行颈总动脉、髂总动脉、股动脉超声筛查,根据超声结果分为无斑块组425例(内中膜厚度IMT≤1.3 mm)及斑块组113例(内中膜厚度IMT>1.3 mm),观察两组间年龄、性别、腰围、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、餐后2 h血糖(2hBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的差异及危险因素。结果①538例新诊断2型糖尿病患者动脉斑块发病率为28.6%;无斑块组颈总动脉、髂总动脉、股动脉IMT分别为(0.74±0.17)mm(、0.74±0.15)mm和(0.74±0.17)mm,斑块组颈总动脉、髂总动脉、股动脉IMT分别为(0.91±0.23)mm、(0.94±0.21)mm和(0.88±0.22)mm,且两组间各动脉的IMT差异具有统计学意义(P<0.05);②斑块组年龄、腰围、BMI、SBP、DBP、FBG2、hBG、HbA1C、HOMA-IR、TG、TC和LDL-C平均水平均比非斑块组高(P<0.05),其中两组间年龄、SBP、FBG、2hBG、TG和LDL-C的差异有统计学意义(P<0.05);③多元逐步回归分析结果显示,年龄、SBP、2h-PBG和TG为新诊断2型糖尿病患者颈总动脉、髂总动脉、股动脉斑块发生的主要危险因素。结论新诊断2型糖尿病动脉斑块发病率高,仅行颈动脉超声检测漏诊率高,糖代谢异常及脂质代谢紊乱对动脉粥样硬化的发生、发展起着重要作用。 Objective To investigate the incidence of artery plaques in newly diagnosed type 2 diabetic patients and its correlated risk factors.Methods B-mode ultrasound was used for screening for plaques located in the common carotid artery,common iliac artery or femoral artery.Based on thickness of IMT,patients were divided into two groups: 425 patients without plaques(IMT≤1.3?mm)and 113 patients with artery plaques(IMT>1.3?mm).Furthermore,differences of age, sex,waistline,BMI,SBP,DBP,FBG,2hBG,HbA1c,HOMA-IR,TG,TC...
出处 《山东大学学报(医学版)》 CAS 北大核心 2009年第7期85-88,共4页 Journal of Shandong University:Health Sciences
基金 国家科技部资助课题(2006BAI02B08)
关键词 2型糖尿病 中膜厚度 动脉粥样斑块 Type 2 diabetes mellitus Intra media thickness Artery atheromatous plaques
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  • 1詹晓蓉,肖彧君,母义明,李明,陆祖谦,陆菊明,潘长玉.花生四烯酸对饱和脂肪酸的血管内皮细胞毒性的保护作用[J].中华内分泌代谢杂志,2004,20(5):453-456. 被引量:9
  • 2Stander J, Vaccaro O, .Neaton J, et al. For the multiple Risk Factor Intervention Trial Research Group: Diabetes other risk factor, and 12 -years cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial [J]. Diabetes Care, 1993, 16:434 -444. 被引量:1
  • 3Pyorala K, Laakso M, Uusitupa M. Diabetes and atheresclerosis: an epidemiologic view [J]. Diabetes Metab Rev, 1987, 3: 463. 被引量:1
  • 4Pignoli P, Tremoli E, Oreste P, et al. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging[J].Circulation, 1986, 74. 1399-1406. 被引量:1
  • 5Baitakari OT, Trikka JO, Laine H, et al. Reduced myocardial flow reserve relates to increased carotid intima - media thickness in healthy young men [J]. Atherosclerosis, 2001, 156:469 -475. 被引量:1
  • 6Kawamori R, Yamasaki Y, Matsushima H, et al. Prevalence of carotid atheresclerosis in diabetic patients [J]. Diabetes Care, 1992, 15:1290 - 1294. 被引量:1
  • 7Pujia A, Gnasso A, Irace C, et al. Common carotid arterial wall thickness in NIDD subjects [J]. Diabetes Care, 1994, 17:1330 -1336. 被引量:1
  • 8Temelkova - Kurktschiev T, Koehler C, Leonhardt W, et al. Increased intima - media thickness in newly detected type 2 diabetes[J]. Diabetes Care, 1999, 22:333-338. 被引量:1
  • 9Wagenknecht LE, D'Agestino RB, Haffner SM, et al. Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atheresclerosis Study [J]. Diabetes Care, 1998, 21:1812-1818. 被引量:1
  • 10Bonora E, Kiechl S, Oberhollenzer F, et al. Impaired glucose tolerance, type 2 diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study [J]. Diabetologia, 2000, 43:156 -164. 被引量:1

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