摘要
目的:优化青藤碱脂质体的膜材处方,并进行制备工艺研究。方法:采用乙醚注入法制备脂质体,以包封率为指标,采用混料均匀设计法优化其膜材处方,确定豆磷脂、胆固醇、维生素E等组分的用量。并在此基础上采用单因素考察法进行制备工艺研究,包括缓冲液用量、制备温度、超声时间等。结果:最佳膜材处方为青藤碱:豆磷脂:胆固醇:维生素E质量化(8.92:60.35:28.81:1.91),缓冲液用量为50 mL.g-1膜材,制备温度为50℃,超声时间为20 min。结论:按此优化处方及工艺制备的脂质体可获得满意的形态及包封率。
Objective:To optimize the formulation and preparation process of sinomenine liposomes.Method:Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids,cholesterol and Vitamin E with the index of entrapment efficiency.And the single-factor test was used to study the preparation process of the liposomes,including the volume of buffer solution,the preparation temperature and the ultrasonic time.Result:The optimized...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第3期275-278,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30672669,30772791)
广东省自然科学基金项目(5300063)
关键词
青藤碱脂质体
处方
制备工艺
sinomenine liposomes
formulation
preparation process
