摘要
目的探讨血浆同型半胱氨酸水平与脑梗死发病危险性的关系。方法200例脑梗死患者测定血浆同型半胱氨酸、叶酸、维生素B12和欧洲脑卒中量表评分等指标,并与100例健康对照者相比较。结果脑梗死组的血浆同型半胱氨酸水平高于对照组(18.54±6.28μmol/L比10.35±3.64μmol/L,P<0.001);脑梗死组叶酸与维生素B12水平(分别为4.62±2.48μg/L、246.4±86.2ng/L)低于对照组(分别为8.36±1.58μg/L、348.3±58.4ng/L,P<0.001)。条件Logistic回归模型检验发现同型半胱氨酸为脑梗死的独立致病因素。脑梗死组血浆同型半胱氨酸水平与欧洲脑卒中量表评分呈负相关(r=-0.684,P<0.001),即脑梗死病情严重程度与血同型半胱氨酸水平呈正相关。脑梗死组血同型半胱氨酸水平与血叶酸和维生素B12水平呈负相关(r=-0.448,P<0.001;r=-0.264,P<0.01)。结论高同型半胱氨酸血症增加了脑梗死的发病危险性,并可加重其病情严重程度。
Aim To investigate the relationship between the risk of cerebral infarction and plasma homocysteine levels. Methods Levels of plasma homocysteine, serum folic acid and vitamin B12 of 200 patients with acute cerebral infarction and 100 healthy subjects were determined. Results The mean plasma homocysteine was significantly higher in the cerebral infarction group (18.54±6.28 μmol/L) compared with that in the control group (10.35±3.64 μmol/L, P<0.001). The mean serum folic acid and vitamin B12 were significantly lower in the cerebral infarction group (4.62±2.48 μg/L and 246.4±86.2 ng/L) compared with those in the control group (8.36±1.58 μg/L and 348.3±58.4 ng/L, P<0.001). Conditional logistic procedure analysis showed that plasma homocysteine was independent risky factor of cerebral infarction. Correlation coefficients between log plasma homocysteine level and serum folic acid, vitamin B12 indicated an inverse correlation (r=-0.448, P<0.001; r=-0.264, P<0.01, respectively). Plasma homocysteine was negatively correlated with the European stroke scale score (r=-0.684,P<0.001). Conclusions Hyperhomocysteinemia increase the risk of cerebral infarction. It can aggravate the pathogenetic condition of cerebral infarction too.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第3期221-223,共3页
Chinese Journal of Arteriosclerosis
