摘要
目的:探究米非司酮联合甲氨蝶呤对宫外孕保守治疗的临床疗效及对患者血清CA125、β-hCG、孕酮水平的影响。方法:选取78例宫外孕患者,分为观察组和对照组各39例。观察组采用米非司酮联合甲氨蝶呤治疗,对照组采用甲氨蝶呤治疗,比较两组疗效和血清CA125、β-hCG及孕酮水平。结果:观察组临床治疗总有效率为94.87%,对照组临床治疗总有效率为79.49%,观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清CA125、β-hCG及孕酮水平比较差异无统计学意义(P>0.05);治疗后,两组血清CA125、β-hCG及孕酮水平较治疗前改善,且观察组血清CA125、β-hCG低于对照组,孕酮水平高于对照组,差异有统计学意义(P<0.05)。结论:米非司酮联合甲氨蝶呤治疗宫外孕效果明显,可改善血清CA125、β-hCG及孕酮水平。
Objective:To investigate the clinical efficacy of Mifepristone combined with Methotrexate in conservative treatment of ectopic pregnancy and its influence on serum CA125,beta-hcg and progesterone levels.Methods:78 cases of ectopic pregnancy patients were selected and divided into observation group and control group with 39 cases in each group.The observation group was treated with Mifepristone combined with Methotrexate,while the control group was treated with Methotrexate.The efficacy of the two groups and serum CA125,beta-hcg and progesterone levels were compared.Results:The total effective rate of clinical treatment was 94.87%in the observation group,and 79.49%in the control group,which was higher than that in the control group,with statistically significant difference(P<0.05).Before treatment,there was no significant difference in serum CA125,beta-hcg and progesterone levels between the two groups(P>0.05).After treatment,serum CA125,beta-hcg and progesterone levels in the two groups were improved compared with that before treatment,and serum CA125 and beta-hcg levels in the observation group were lower than those in the control group,while progesterone levels were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Mifepridone combined with Methotrexate is effective in treating ectopic pregnancy,and can improve serum CA125,beta-hcg and progesterone levels.
作者
林冰
LIN Bing(Department of Obstetrics and Gynecology,The People’s Hospital of Zhongshan City,Zhongshan 528403,China)
出处
《华夏医学》
CAS
2020年第1期115-118,共4页
Acta Medicinae Sinica
