摘要
目的分析广东省珠海市甲状腺癌发病特征及其变化趋势。方法利用珠海市肿瘤登记处2010-2017年甲状腺癌发病资料,计算甲状腺癌发病率、中标发病率、世标发病率、平均发病年龄、标化平均发病年龄和病理学类型构成比等指标,并采用Joinpoint软件和线性回归分析发病趋势和年龄变化趋势。结果珠海市甲状腺癌粗发病率为12.97/10万,中标发病率为11.14/10万,世标发病率为9.75/10万,女性发病率高于男性,中标率为男性的3.05倍。甲状腺癌发病率由2010年的4.44/10万增加至2017年的21.05/10万,年度变化百分比(APC)为20.12%,呈逐年上升趋势(P<0.001)。甲状腺癌病理学类型以乳头状癌为主,占96.23%,其发病率呈上升趋势,APC为20.20%(P<0.001)。乳头状癌的亚分类中乳头状腺癌和微小癌的发病率呈逐年上升趋势,APC分别为19.30%和26.70%(P<0.05)。甲状腺癌发病率随年龄增加而上升,到50~54岁年龄组达到顶峰,40~49岁年龄组上升速率最快,APC为24.48%。珠海市甲状腺癌平均发病年龄变化趋势稳定(P>0.05),平均发病年龄为44.38岁,标化平均发病年龄为44.23岁。结论珠海市甲状腺癌发病率处于我国较高水平,呈快速上升趋势,政府部门需尽快调查清楚原因,并制定针对性防控措施,以遏制甲状腺癌的快速增长。
Objective To analyze the incidence characteristics and changing trend of thyroid cancer in Zhuhai from 2010 to 2017.Methods Incidence data of thyroid cancer from Zhuhai cancer registry during the period 2010 to 2017 were used to calculate the crude incidence rate,age-standardized rates by Chinese and world standard population,mean age of onset and proportion of pathological type.The Joinpoint software and liner regression were used to analyze the incidence and age change trend,respectively.Results The crude incidence rate of thyroid cancer was 12.97/105;based on Chinese and world standard population,age-standardized rates of thyroid cancer were 11.14/105 and 9.75/105,respectively.The incidence rate in females was significantly higher than that in males,and it was 3.05 times as high as that in males.The incidence rate of thyroid cancer rose from 4.44/105 in 2010 to 21.05/105 in 2017,which were on rise year by year(APC=20.12%,P<0.001).Papillary thyroid carcinoma was the dominant type,accounting for 96.23%,and had an upward trend of incidence rate with APC of 20.20%(P<0.001).The incidence rates of papillary carcinoma and micro-carcinoma increased year by year and APC were 19.30%and 26.70%,respectively(P<0.05).The incidence rate of thyroid cancer increased with age,reaching the peak at 50-54 years of age,and 40-49 years age group had the fastest rise speed(APC=24.48%,P<0.05).The mean age and adjusted mean age of thyroid cancer cases were 44.38 and 44.23 years old,respectively,and age-changing trend held steady from 2010-2017(P>0.05).Conclusion From 2010 to 2017,the incidence rate of thyroid cancer in Zhuhai kept a relatively high level in China,and it was on the rise rapidly.Government departments need to investigate the cause as soon as possible and formulate targeted prevention and control measures to curb the rapid growth of thyroid cancer.
作者
滕勇勇
谢水仙
陈美婷
赵金利
陈伟
郭红革
TENG Yongyong;XIE Shuixian;CHEN Meiting;ZHAO Jinli;CHEN Wei;GUO Hongge(Zhuhai Center for Chronic Disease Control,Zhuhai 519000,China)
出处
《河南预防医学杂志》
2021年第8期578-582,共5页
Henan Journal of Preventive Medicine
关键词
甲状腺癌
发病
趋势
肿瘤登记
珠海
Thyroid cancer
Incidence
Trend
Cancer registration
Zhuhai
