摘要
目的分析莫西沙星在耐多药肺结核患者治疗中的应用价值及不良反应。方法选择2019年4月到2020年4月期间在我院治疗的86例耐多药肺结核患者,其中应用莫西沙星治疗的43例纳入观察组,另外使用左氧氟沙星治疗的43例纳入对照组,分析两组不良反应及疗效。结果观察组的不良反应率比对照组小,治疗12个月的痰菌转阴率比对照组高,治疗总有效率比对照组高,治疗后,观察组FEF、FEV1等肺功能指标水平高于对照组,观察组IL-1、IL-6、TNF-α等炎性因子指标水平均低于对照组(P<0.05)。结论莫西沙星的运用能够较好的清除细菌,针对耐多药肺结核有更确切的疗效。
Objective To analyze the application value and adverse reactions of moxifloxacin in the treatment of patients with multi-drug resistant tuberculosis.Methods 86 patients with multi-drug resistant tuberculosis treated in our hospital from April 2019 to April 2020 were selected,of which 43 patients treated with moxifloxacin were included in the observation group,and 43 patients treated with levofloxacin were included in the control group.Analysis of adverse reactions and efficacy of the two groups.Results The adverse reaction rate of the observation group was lower than that of the control group,and the conversion rate of sputum bacteria after 12 months of treatment was higher than that of the control group,and the total effective rate of treatment was higher than that of the control group.After treatment,the levels of FEF,FEV1 and other lung function indexes in the observation group were higher than those in the control group,and the levels of inflammatory factors such as IL-1,IL-6,TNF-αin the observation group were lower than those in the control group(P<0.05).Conclusion The application of moxifloxacin can eliminate bacteria better,and it has a more precise effect against multi-drug resistant tuberculosis.
作者
黄海燕
HUANG Hai-yan(Lanling County Tuberculosis Control Center,Linyi,Shandong 277700)
出处
《智慧健康》
2021年第5期127-129,共3页
Smart Healthcare
关键词
耐多药肺结核
治疗
莫西沙星
左氧氟沙星
不良反应
Multi-drug resistant tuberculosis
Treatment
Moxifloxacin
Levofloxacin
Adverse reactions
