摘要
目的分析不同程度抑郁障碍患者工作记忆损害差异及其影响因素,为抑郁障碍认知功能的临床评估提供依据。方法选择2019年1月—2020年11月在某三甲医院精神科和临床心理科就诊的抑郁障碍患者为调查对象,收集患者的人口学信息、病程和服药等资料,采用心理健康测查表(PHI)中的抑郁亚量表(Dep)评估患者抑郁障碍程度,采用N-back任务评估患者工作记忆损害程度,分析不同程度抑郁障碍患者N-back任务错误率和反应时差异;采用多重线性回归模型分析抑郁障碍患者工作记忆损害的影响因素。结果纳入抑郁障碍患者75例,其中轻度抑郁障碍45例,中重度抑郁障碍30例。N-back任务结果显示,轻度和中重度抑郁障碍患者3-back任务错误率分别为(27.47±20.59)%和(39.60±25.95)%,0-back、1-back、2-back和3-back任务反应时分别为(458.29±104.19)ms和(527.90±99.58)ms,(499.87±85.46)ms和(574.57±126.25)ms,(567.44±114.86)ms和(675.37±137.54)ms以及(663.76±167.99)ms和(753.27±152.06)ms,差异均有统计学意义(P<0.05)。多重线性回归分析结果显示,抑郁障碍严重程度是0-back~3-back任务反应时和3-back任务错误率的影响因素,服药是0-back任务反应时的影响因素(均P<0.05)。结论不同程度抑郁障碍患者工作记忆损害存在差异,与抑郁障碍严重程度和服用抗抑郁药物有关。
Objective To analyze the working memory impairment in patients with different degrees of depressive disorder and its influencing factors,so as to provide the basis for the clinical evaluation of cognitive function in patients with depressive disorder.Methods From January 2019 to November 2020,the patients with depressive disorder were selected in the psychiatry and clinical psychology departments of a tertiary hospital.Demographic information,disease course and medication were collected.Depression sub scale(DEP)of Mental Health Inventory(PHI)was used to measure the degree of depressive disorder.N-back tasks were used to test working memory,with error rate and reaction time as experimental variables to compare the working memory impairment of patients with different degrees of depressive disorder.The multivariate linear regression model was used to analyze the influencing factors for working memory impairment in patients with depressive disorder.Results A total of 75 patients with depressive disorder were included,including45 mild cases and 30 moderate and severe cases.The error rates of mild cases and moderate and severe cases in the3-back task were(27.47±20.59)%and(39.60±25.95)%,the response time between the two groups in 0-back,1-back,2-back and 3-back task were(458.29±104.19)ms and(527.90±99.58)ms,(499.87±85.46)ms and(574.57±126.25)ms,(567.44±114.86)ms and(675.37±137.54)ms,(663.76±167.99)ms and(753.27±152.06)ms,the differences between two groups were significant(P<0.05).The multivariate linear regression analysis showed that the severity of depressive disorder was correlated with the response time of 0-back to 3-back tasks and the error rate of 3-back task;whether patients took medicine or not was depressive disorder correlated with the 0-back task response time(all P<0.05).Conclusion There are differences in working memory impairment among patients with different degrees of depressive disorder and the severity of impairment is correlated with the severity of depressive disorder and the use of antide
作者
余鸽
娄乐
徐方忠
YU Ge;LOU Le;XU Fangzhong(Department of Clinical Psychology,Tongde Hospital of Zhejiang Province,Hangzhou,Zhejiang 310012,China;不详)
出处
《预防医学》
2021年第7期675-678,684,共5页
CHINA PREVENTIVE MEDICINE JOURNAL
基金
浙江省软科学研究计划(2021C35114)
