Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical industry.The most critical process parameters of HSG are ...Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical industry.The most critical process parameters of HSG are discussed in this work.The main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all scales.The scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based methods.An engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule attributes.This work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling strategies.The aim is to review applied scale-up approaches in HSG and discuss benefits and limitations.It is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.展开更多
Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can be challenging and mortality remains high regardless of its management. A 50-year-old man admitted with cardiac arrest, w...Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can be challenging and mortality remains high regardless of its management. A 50-year-old man admitted with cardiac arrest, whose physical examination and echocardioscopy suggested PVT confirmed with fluoroscopy. Intra-aortic fibrinolysis was the treatment chosen with successful results.展开更多
Soybean is the most produced oil crop in the world, with great increase in its annual production as well as great generation of waste from its industrialization. The soybean hulls can be used for the elaboration of pr...Soybean is the most produced oil crop in the world, with great increase in its annual production as well as great generation of waste from its industrialization. The soybean hulls can be used for the elaboration of products such as carboxymethyl cellulose (CMC), adding high value to this residue and it can be used as a coating polymer in seeds. The objective of this work was to analyze the physiological quality of soybean seeds treated with CMC and fungicide, recording images to verify the effectiveness of the coating in the seeds. The experiment was randomized into factorial scheme 2 × 4 with four replicates, two soybean cultivars M-7110 and M-7739 and four types of coating: without (control), CMC, fungicide and fungicide/CMC. The variables analyzed were: vigor (first count), germination test, accelerated aging, length and dry mass of the radicle and hypocotyl length. The images were made with a scanning electron microscope (SEM) with zoom of 50 and 200 times. The CMC used alone or with fungicide, provided good physiological quality of soybean seeds. In some analyzes there was difference between the cultivars M 7110 and M 7739. The combination of CMC and fungicide provided a better coating on the seeds.展开更多
There are two widely used radiative models without consideration of aerosol inhomogeneity for satellite remote sensing application, the Homogeneous Model and the Two-layer Model with aerosol in the lower layer. In thi...There are two widely used radiative models without consideration of aerosol inhomogeneity for satellite remote sensing application, the Homogeneous Model and the Two-layer Model with aerosol in the lower layer. In this paper, effects of the aerosol vertical inhomogeneity on upwelling radiance and satellite remote sensing of surface reflectance are analyzed through numerical simulations by using two models. As shown in the simulations by using 24 representative aerosol models, there is often a considerably large error in upwel-ling radiance calculated by two models (Homogeneous and Two-layer) for the short wavelength channel with strong molecular scattering, owing to the difference between molecular and aerosol scattering proper-ties. For the long wavelength channel, the error is small if aerosol optical parameters are less variable with height, but it could also be significant if there are aerosol layers with different scattering phase functions and single scattering albedo. The radiance errors by the Homogeneous Model and the Two-layer Model can be up to 31.4% and 31.5% for the clean atmosphere, and in case of turbid atmosphere 67.8% and 59.2%, respectively. The radiance error could result in a large uncertainty of surface reflectance retrievals, especially for the short wavelength channel and the strongly absorbing aerosol. For the turbid atmosphere with strong-ly absorbing aerosol, the Homogeneous Model and the Two-layer Model are not suitable for atmospheric correction application. Key words Satellite remote sensing - Aerosol inhomogeneity - Surface reflectance - Radiance展开更多
Multilingual abstracts:Please see Additional file 1 for translations of the abstract into the five official working languages of the United Nations.Background:Currently,in Brazil,there is a co-circulation of the four ...Multilingual abstracts:Please see Additional file 1 for translations of the abstract into the five official working languages of the United Nations.Background:Currently,in Brazil,there is a co-circulation of the four dengue(DENV-1 to DENV-4)serotypes.This study aimed to assess whether different serotypes and antibody response patterns were associated with the severity of the disease during a dengue outbreak,which occurred in 2012/2013 in centre of Brazil.Methods:We conducted a prospective study with 452 patients with laboratory confirmed dengue in central Brazil,from January 2012 to July 2013.The clinical outcome was the severity of cases:dengue,dengue with warning signs,and severe dengue.The patients were evaluated at three different moments.Blood sampling for laboratory testing and confirmatory tests for dengue infection were performed.We performed a multinomial analysis considering the three categories of the dependent variable,as outlined above.The odds ratios(ORs)were calculated.A multinomial logistic regression model was applied for variables with a P-value<0.20.Statistical analysis was performed with STATA 12.0 software.Results:Four hundred fifty-two patients(452/632,71.5%)were diagnosed with dengue.The dengue virus(DENV)serotypes were identified in 243 cases.DENV-4 was detected in 135 patients(55.6%),DENV-1 in 91(37.4%),DENV-3 in 13(5.3%),and DENV-2 in 4(1.6%).Patients with the DENV-1 serotype were more prone to present with several clinical and laboratory features as compared with DENV-4 patients,including spontaneous bleeding(P=0.03),intense abdominal pain(P=0.004),neurological symptoms(P=0.09),and thrombocytopenia(P=0.01).Secondary infection was more predominant among DENV-4 cases(80.0%)compared with DENV-1 cases(62.3%)(P=0.03).The univariate analysis showed that females(OR=2.12;95%CI:1.44-3.13;P<0.01)had a higher risk of having dengue with warning signs.The multinomial analysis showed that severe dengue cases with secondary infection had an adjusted OR of 2.80(95%CI:0.78-10.00;P=0.113)as compared with展开更多
The purpose of this paper is to study about the interrelationship between the backscattering intensity of PALSAR data and the laboratory measurement of dielectric constant and soil moisture. The characterization of th...The purpose of this paper is to study about the interrelationship between the backscattering intensity of PALSAR data and the laboratory measurement of dielectric constant and soil moisture. The characterization of the dielectric constant of arid soils in the 0.3 - 3 GHz frequency range, particularly focused in L-band was analyzed in varied soil moisture content and soil textures. The interrelationship between the relative dielectric constant with soil textures and backscattering of PALSAR data was also analyzed and statistical model was computed. In this study, after collecting the soil samples in the field from top soil (0 - 10 cm) in a homogeneous area then, the dielectric constant was measured using a dielectric probe tool kit. For investigated of the characteristics and behaviors of the dielectric constant and relationship with backscattering a variety of moisture content from 0% to 40% and soil fraction conditions was tested in laboratory condition. All data were analyzed by integrating it with other geophysical data in GIS, such as land cover and soil texture. Thus, the regression model computed between measured soil moisture and backscattering coefficient of PALSR data which were extracted as same point of each soil sample pixel. Finally, after completing the preprocessing, such as removing the speckle noise by averaging, the model was applied to the PALSAR data for retrieving the soil moisture map in arid region of Iran. The analysis of dielectric constant properties result has shown the soil texture after the moisture content has the largest effected on dielectric constant. In addition, the PALSAR data in dual polarization are also able to derive the soil moisture using statistical method. The dielectric constant and backscattering shown have the exponential relationship and the HV polarization mode is more sensitive than the HH mode to soil moisture and overestimated the soil moisture as well. The validation of result has shown the 4.2 Vol-% RMSE of soil moisture. It means that the backscattering analy展开更多
It has been commonly acknowledged that the current global mapping projects have encountered the accuracy challenge. By conducting a comparison among the four existing global land cover datasets (MODIS LC, GLC2000, GLC...It has been commonly acknowledged that the current global mapping projects have encountered the accuracy challenge. By conducting a comparison among the four existing global land cover datasets (MODIS LC, GLC2000, GLCNMO and GLOBCOVER), it has been identified that certain areas’ accuracy has dragged down the overall accuracy of these global land cover datasets. In this paper, those areas have been defined as the “unreliable area”. This study has recollected the training data from the “unreliable area” within the above four mentioned datasets and reclassified the “unreliable area” by using two supervised classifications. The final result has shown that compared with any existing datasets, a relatively higher accuracy has been able to achieve.展开更多
The purpose of this paper is to simulate the backscattered signal by experimental data and field working then, comparing with the backscattered signal from actual L-band SAR data over arid to semi-arid environments. T...The purpose of this paper is to simulate the backscattered signal by experimental data and field working then, comparing with the backscattered signal from actual L-band SAR data over arid to semi-arid environments. The experimental data included the laboratory-measured dielectric constant of soil samples and the roughness parameter. A backscattering model used to simulate the backscattering coefficient in sparse vegetation land cover. The backscattering coefficient (σ0) simulated using the AIEM (advanced integral equation model) based on the experimental data. The roughness data were considered by the field observation, chain method measuring and photogrammetry simulation technique by stereo image of ground real photography. The simulated backscattering coefficients were compared with the real extracted backscattering coefficient (σ0) from the ALOS PALSAR single and dual polarization mode data. The most problem in backscattering simulation was the vegetation water content. Therefore, the water-cloud model using the water index result of optical data applied on the simulated backscatter model for enhancement the backscattering heterogeneity from vegetation water contents due to the mix pixel of vegetation in spars vegetation. At the results the AIEM model overestimated the backscattering simulation, it might be cause of high sensitivity of this model to roughness. The ALOS PALSAR HV polarization mode is more sensitive than the HH mode to vegetation water content. The water-cloud model could improve the result and the correlation function of the samples was increased but, the difficulties were the input the A and B parameters to model.展开更多
Alzheimer’s disease is accompanied by progressive aphasia which intensifies the cognitive problems. The quality of the care given to the patient influences, however, the evolution of his language difficulties. The wa...Alzheimer’s disease is accompanied by progressive aphasia which intensifies the cognitive problems. The quality of the care given to the patient influences, however, the evolution of his language difficulties. The way the vulnerable person is aided, and the extent to which his efforts to make himself understood by his human environment are validated, contribute to preventing the development of a feeling of failure, a tendency to give up, and retrogressive tendencies. Repetition of interpersonal disqualifiers, care dispensed neglecting inter subjectivity, to the contrary encourages the patient to limit contact with his environment and so precipitate his language difficulties. Aphasia is thus linked to the insufficiency of human communication. The consequences of this disorder can be limited by taking into account the phatic language function to keep communication channels open. The human relationship is an encounter, an act of mutual identity-giving. Alzheimer-patient identity break-down is linked to cognitive troubles and to the failure of patients’ relationship attempts.展开更多
A regional map of mangrove forests was produced for six islands located in the southern part of Japan by integrating the spectral analyses of Landsat Enhanced Thematic Mapper plus (ETM+) images with a digital elevatio...A regional map of mangrove forests was produced for six islands located in the southern part of Japan by integrating the spectral analyses of Landsat Enhanced Thematic Mapper plus (ETM+) images with a digital elevation model (DEM). Several attempts were applied to propose a reliable method, which can be used to map the distribution of mangrove forests at a regional scale. The methodology used in this study comprised of obtaining the difference between Normalized Difference Water Index (NDWI) and Normalized Difference Vegetation Index (NDVI), band ratio 5/4, and band 5, from Landsat ETM+, and integrating them with the topographic information. The integration of spectral analyses with topographic data has clearly separated the mangrove forests from other vegetation. An accuracy assessment was carried out in order to check the accuracy of the results. High overall accuracy ranging from 89.3% to 93.6% was achieved, which increased the opportunity to use this methodology in other countries rich in mangrove forests.展开更多
Alzheimer’s Disease (AD) is a neurodegenerative illness with frequency of occurrence increasing with old age. If memory impairment setting progressively is here an element associated upfront, other neurocognitive tro...Alzheimer’s Disease (AD) is a neurodegenerative illness with frequency of occurrence increasing with old age. If memory impairment setting progressively is here an element associated upfront, other neurocognitive troubles are also associated, for example, language impairment which can degenerate into aphasia. Aim of the study. To evaluate semantic and textual impairment in AD. Methods. Populations studied concerned 151 AD patients in consultation at Brest University Hospital. Certain sociodemographic data (sex, age, cultural levels) were collected as well as results from neuropsychological tests: (Folstein-MMSE;Dubois’s 5-word test;fluencies, Dubois’ s frontal test battery;Cornell’s scale for depression;Barbizet’s test, “The Lion’s tale”, for textual analysis. Demented patients were composed of 102 females and 49 males of average age 80.3 ± 6.91. All the tests, including the number of items memorized latterly in the Barbizet’s test are impaired all the more by Folstein’s test being altered. The formal fluency on demented patients is less impaired than the semantic lexical fluency test (scored respectively 5.74 ± 1. 09 versus 4.41 ± 2. 19;t = 5.60, p < 0.01). The studied demented cohort shows more intrusions (n = 36) than inversions in the delayed Lion’s tale, whether for items or for episodes in which they occur (n = 19). The regressive PLS analysis shows that for the explanation of the overall scores to do with “The lion’s tale”, calculated later, only attainment of formal fluency has any notable influence (Regression coefficient CR = 0.224) or, more accessorily, the cultural level (CR = 0.12). Conclusions: Attainment of category fluency and patient culture levels has effects on narrativity.展开更多
In this paper, a new method for canopy water content (FMC) estimation for highly vegetated surfaces- shortwave infrared perpendicular water stress index (SPSI) is developed using NIR, SWIR wavelengths of Enhanced Them...In this paper, a new method for canopy water content (FMC) estimation for highly vegetated surfaces- shortwave infrared perpendicular water stress index (SPSI) is developed using NIR, SWIR wavelengths of Enhanced Thematic Mapper Plus (ETM+) on the basis of spectral features and distribution of surface targets with different water conditions in NIR-SWIR spectral space. The developed method is further explored with radiative transfer simulations using PROSPECT, Lillesaeter, SailH and 6S. It is evident from the results of validation derived from satellite synchronous field measurements that SPSI is highly correlated with FMC, coefficient of determination (R squared) and root mean square error are 0.79 and 26.41%. The paper concludes that SPSI has a potential in vegetation water content estimation in terms of FMC.展开更多
The efifciency of extracts from Arbutus unedo L. （AU）, Crataegus monogyna L. （CM）, Rosa canina L. （RC）, and Rubus ulmifolius Schott. （RU） to inhibit lipid oxidation in raw, cooked and cooked and chilled （2...The efifciency of extracts from Arbutus unedo L. （AU）, Crataegus monogyna L. （CM）, Rosa canina L. （RC）, and Rubus ulmifolius Schott. （RU） to inhibit lipid oxidation in raw, cooked and cooked and chilled （2°C/12 d） porcine burger patties, was investigated. The modiifcation of the fatty acid proifle during processing treatments （cooking and chilling）, the quantitative measurements of thiobarbituric acid reactive substances （TBA-RS）, and lipid-derived volatiles, were used as indicators of lipid oxidation. Polyunsaturated fatty acids （PUFA） gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being signiifcantly greater （P〈0.05） in control patties than in those with added berry extracts. In accordance, the control patties showed signiifcantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts （P〈0.05）. Results from the present work show, for the ifrst time, that extracts from A. unedo, C. monogyna, R. canina, and R. ulmifolius are promising antioxidants which could enhance the nutritional, safety and sensory properties of porcine burger patties.展开更多
近几十年来,全球生态系统、气候和生物多样性已不同程度受到人口快速增长和城市持续扩张带来的负面影响.使用低分辨率遥感影像数据和GIS技术定量分析了近40a全球城市时空变化.世界数字化图(Digital Chart of the World,DCW)城市图层代表...近几十年来,全球生态系统、气候和生物多样性已不同程度受到人口快速增长和城市持续扩张带来的负面影响.使用低分辨率遥感影像数据和GIS技术定量分析了近40a全球城市时空变化.世界数字化图(Digital Chart of the World,DCW)城市图层代表1960年至1970年的全球城市面积,利用MODIS影像数据、稳定夜间光数据和城市格网人口密度数据编制的全球土地覆盖数据城市图(GlobalLand Cover by National Mapping Organization,GLCNMO)代表2003年时的全球城市面积.计算了1960年和2003年全球城市的城市用地比重和年城市增长率指数,从区域尺度、国家尺度和单个城市尺度分析了全球城市扩展的时空变化过程.结果表明:在1960年代发达国家城市面积较大,而发展中国家城市面积小得多;到2003年发展中国家有相当大的变化,新增长的城市区域快速扩大.近40a来发展中国家城市区域发展速度远快于发达国家,与欧洲和北美国家相比,发展中国家城市结构更紧凑和密集.展开更多
Global land cover is one of the fundamental contents of Digital Earth.The Global Mapping project coordinated by the International Steering Committee for Global Mapping has produced a 1-km global land cover datasetGlo...Global land cover is one of the fundamental contents of Digital Earth.The Global Mapping project coordinated by the International Steering Committee for Global Mapping has produced a 1-km global land cover datasetGlobal Land Cover by National Mapping Organizations.It has 20 land cover classes defined using the Land Cover Classification System.Of them,14 classes were derived using supervised classification.The remaining six were classified independently:urban,tree open,mangrove,wetland,snow/ice,andwater.Primary source data of this land cover mapping were eight periods of 16-day composite 7-band 1-km MODIS data of 2003.Training data for supervised classification were collected using Landsat images,MODIS NDVI seasonal change patterns,Google Earth,Virtual Earth,existing regional maps,and expert’s comments.The overall accuracy is 76.5%and the overall accuracy with the weight of the mapped area coverage is 81.2%.The data are available from the Global Mapping project website(http://www.iscgm.org/).TheMODISdata used,land cover training data,and a list of existing regional maps are also available from the CEReS website.This mapping attempt demonstrates that training/validation data accumulation from different mapping projects must be promoted to support future global land cover mapping.展开更多
Objective: To evaluate the potential of commercial fermented products sold in the country,and strains of Lactobacillus plantarum(L,plantarum)as prophylaxis and therapy against diarrhoea in children,Methods: The antimi...Objective: To evaluate the potential of commercial fermented products sold in the country,and strains of Lactobacillus plantarum(L,plantarum)as prophylaxis and therapy against diarrhoea in children,Methods: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk(DLSM),Probrand sour milk(PSM),Kefalos Vuka cheese(KVC) and Chibuku opaque beer(COB); and four strains of L,plantarum obtained from Balkan traditional cheeses against clinical strains of Escherichia coli(E,coli) was assayed using the well diffusion method,Three commercial paediatric antidiarrhoeal drug products: Biogaia(BG),Prolife(PL) and Probio Junior(PJ) and a mutant strain of E,coli [strain 11105(ATCC)- a vitamin B-12 auxotroph and penicillin G acylase-producing strain] were used as controls,An agar diffusion assay and a competitive exclusion assay were carried out on Mueller Hinton agar,Results: Crude cultures of putative lactobacillus strains obtained from Zimbabwean dairy products(Probrand sour milk,Kefalos Vuka vuka cheese and Chibuku opaque beer) had significantly higher antimicrobial activities against clinical strains of E,coli than strains of L,plantarum isolated from Balkan cheeses(CLP1,CLP2 or CLP3) and crude microbial cultures from commercial paediatric probiotic products(BG,PJ and PL) of a culture of Lactobacillus rhamnosus LGG(P<0.05),Conclusions: The putative Lactobacilli from four commercial Zimbabwean dairy products(Probrand sour milk,Kefalos Vuka vuka cheese and Chibuku opaque beer),and three strains of L,plantarum from Balkan cheeses(CLP1,CLP2 or CLP3) exhibited high antibacterial activities that can be harnessed to control paediatric diarrhoea that is caused by pathogenic strains of E,coli,Studies to characterise the probiotic potential of the live cultures in the products and the new strains of L,plantarum are underway.展开更多
基金Fundação para a Ciência e Tecnologia(FCT-MCTES)Portugal,under contract UIDB/00102/2020Bluepharma,Coimbra,Portugal.The authors would like to acknowledge FCT for the financial support to João Gomes(CEECIND/01207/2018).
文摘Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical industry.The most critical process parameters of HSG are discussed in this work.The main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all scales.The scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based methods.An engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule attributes.This work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling strategies.The aim is to review applied scale-up approaches in HSG and discuss benefits and limitations.It is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.
文摘Prosthetic valve thrombosis (PVT) is a rare but serious entity. Its diagnosis and treatment can be challenging and mortality remains high regardless of its management. A 50-year-old man admitted with cardiac arrest, whose physical examination and echocardioscopy suggested PVT confirmed with fluoroscopy. Intra-aortic fibrinolysis was the treatment chosen with successful results.
文摘Soybean is the most produced oil crop in the world, with great increase in its annual production as well as great generation of waste from its industrialization. The soybean hulls can be used for the elaboration of products such as carboxymethyl cellulose (CMC), adding high value to this residue and it can be used as a coating polymer in seeds. The objective of this work was to analyze the physiological quality of soybean seeds treated with CMC and fungicide, recording images to verify the effectiveness of the coating in the seeds. The experiment was randomized into factorial scheme 2 × 4 with four replicates, two soybean cultivars M-7110 and M-7739 and four types of coating: without (control), CMC, fungicide and fungicide/CMC. The variables analyzed were: vigor (first count), germination test, accelerated aging, length and dry mass of the radicle and hypocotyl length. The images were made with a scanning electron microscope (SEM) with zoom of 50 and 200 times. The CMC used alone or with fungicide, provided good physiological quality of soybean seeds. In some analyzes there was difference between the cultivars M 7110 and M 7739. The combination of CMC and fungicide provided a better coating on the seeds.
文摘There are two widely used radiative models without consideration of aerosol inhomogeneity for satellite remote sensing application, the Homogeneous Model and the Two-layer Model with aerosol in the lower layer. In this paper, effects of the aerosol vertical inhomogeneity on upwelling radiance and satellite remote sensing of surface reflectance are analyzed through numerical simulations by using two models. As shown in the simulations by using 24 representative aerosol models, there is often a considerably large error in upwel-ling radiance calculated by two models (Homogeneous and Two-layer) for the short wavelength channel with strong molecular scattering, owing to the difference between molecular and aerosol scattering proper-ties. For the long wavelength channel, the error is small if aerosol optical parameters are less variable with height, but it could also be significant if there are aerosol layers with different scattering phase functions and single scattering albedo. The radiance errors by the Homogeneous Model and the Two-layer Model can be up to 31.4% and 31.5% for the clean atmosphere, and in case of turbid atmosphere 67.8% and 59.2%, respectively. The radiance error could result in a large uncertainty of surface reflectance retrievals, especially for the short wavelength channel and the strongly absorbing aerosol. For the turbid atmosphere with strong-ly absorbing aerosol, the Homogeneous Model and the Two-layer Model are not suitable for atmospheric correction application. Key words Satellite remote sensing - Aerosol inhomogeneity - Surface reflectance - Radiance
基金This study was funded by the National Council for Scientific and Technological Development(Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,CNPq)the Foundation for the State of Goiás Research(FAPEG).
文摘Multilingual abstracts:Please see Additional file 1 for translations of the abstract into the five official working languages of the United Nations.Background:Currently,in Brazil,there is a co-circulation of the four dengue(DENV-1 to DENV-4)serotypes.This study aimed to assess whether different serotypes and antibody response patterns were associated with the severity of the disease during a dengue outbreak,which occurred in 2012/2013 in centre of Brazil.Methods:We conducted a prospective study with 452 patients with laboratory confirmed dengue in central Brazil,from January 2012 to July 2013.The clinical outcome was the severity of cases:dengue,dengue with warning signs,and severe dengue.The patients were evaluated at three different moments.Blood sampling for laboratory testing and confirmatory tests for dengue infection were performed.We performed a multinomial analysis considering the three categories of the dependent variable,as outlined above.The odds ratios(ORs)were calculated.A multinomial logistic regression model was applied for variables with a P-value<0.20.Statistical analysis was performed with STATA 12.0 software.Results:Four hundred fifty-two patients(452/632,71.5%)were diagnosed with dengue.The dengue virus(DENV)serotypes were identified in 243 cases.DENV-4 was detected in 135 patients(55.6%),DENV-1 in 91(37.4%),DENV-3 in 13(5.3%),and DENV-2 in 4(1.6%).Patients with the DENV-1 serotype were more prone to present with several clinical and laboratory features as compared with DENV-4 patients,including spontaneous bleeding(P=0.03),intense abdominal pain(P=0.004),neurological symptoms(P=0.09),and thrombocytopenia(P=0.01).Secondary infection was more predominant among DENV-4 cases(80.0%)compared with DENV-1 cases(62.3%)(P=0.03).The univariate analysis showed that females(OR=2.12;95%CI:1.44-3.13;P<0.01)had a higher risk of having dengue with warning signs.The multinomial analysis showed that severe dengue cases with secondary infection had an adjusted OR of 2.80(95%CI:0.78-10.00;P=0.113)as compared with
文摘The purpose of this paper is to study about the interrelationship between the backscattering intensity of PALSAR data and the laboratory measurement of dielectric constant and soil moisture. The characterization of the dielectric constant of arid soils in the 0.3 - 3 GHz frequency range, particularly focused in L-band was analyzed in varied soil moisture content and soil textures. The interrelationship between the relative dielectric constant with soil textures and backscattering of PALSAR data was also analyzed and statistical model was computed. In this study, after collecting the soil samples in the field from top soil (0 - 10 cm) in a homogeneous area then, the dielectric constant was measured using a dielectric probe tool kit. For investigated of the characteristics and behaviors of the dielectric constant and relationship with backscattering a variety of moisture content from 0% to 40% and soil fraction conditions was tested in laboratory condition. All data were analyzed by integrating it with other geophysical data in GIS, such as land cover and soil texture. Thus, the regression model computed between measured soil moisture and backscattering coefficient of PALSR data which were extracted as same point of each soil sample pixel. Finally, after completing the preprocessing, such as removing the speckle noise by averaging, the model was applied to the PALSAR data for retrieving the soil moisture map in arid region of Iran. The analysis of dielectric constant properties result has shown the soil texture after the moisture content has the largest effected on dielectric constant. In addition, the PALSAR data in dual polarization are also able to derive the soil moisture using statistical method. The dielectric constant and backscattering shown have the exponential relationship and the HV polarization mode is more sensitive than the HH mode to soil moisture and overestimated the soil moisture as well. The validation of result has shown the 4.2 Vol-% RMSE of soil moisture. It means that the backscattering analy
文摘It has been commonly acknowledged that the current global mapping projects have encountered the accuracy challenge. By conducting a comparison among the four existing global land cover datasets (MODIS LC, GLC2000, GLCNMO and GLOBCOVER), it has been identified that certain areas’ accuracy has dragged down the overall accuracy of these global land cover datasets. In this paper, those areas have been defined as the “unreliable area”. This study has recollected the training data from the “unreliable area” within the above four mentioned datasets and reclassified the “unreliable area” by using two supervised classifications. The final result has shown that compared with any existing datasets, a relatively higher accuracy has been able to achieve.
文摘The purpose of this paper is to simulate the backscattered signal by experimental data and field working then, comparing with the backscattered signal from actual L-band SAR data over arid to semi-arid environments. The experimental data included the laboratory-measured dielectric constant of soil samples and the roughness parameter. A backscattering model used to simulate the backscattering coefficient in sparse vegetation land cover. The backscattering coefficient (σ0) simulated using the AIEM (advanced integral equation model) based on the experimental data. The roughness data were considered by the field observation, chain method measuring and photogrammetry simulation technique by stereo image of ground real photography. The simulated backscattering coefficients were compared with the real extracted backscattering coefficient (σ0) from the ALOS PALSAR single and dual polarization mode data. The most problem in backscattering simulation was the vegetation water content. Therefore, the water-cloud model using the water index result of optical data applied on the simulated backscatter model for enhancement the backscattering heterogeneity from vegetation water contents due to the mix pixel of vegetation in spars vegetation. At the results the AIEM model overestimated the backscattering simulation, it might be cause of high sensitivity of this model to roughness. The ALOS PALSAR HV polarization mode is more sensitive than the HH mode to vegetation water content. The water-cloud model could improve the result and the correlation function of the samples was increased but, the difficulties were the input the A and B parameters to model.
文摘Alzheimer’s disease is accompanied by progressive aphasia which intensifies the cognitive problems. The quality of the care given to the patient influences, however, the evolution of his language difficulties. The way the vulnerable person is aided, and the extent to which his efforts to make himself understood by his human environment are validated, contribute to preventing the development of a feeling of failure, a tendency to give up, and retrogressive tendencies. Repetition of interpersonal disqualifiers, care dispensed neglecting inter subjectivity, to the contrary encourages the patient to limit contact with his environment and so precipitate his language difficulties. Aphasia is thus linked to the insufficiency of human communication. The consequences of this disorder can be limited by taking into account the phatic language function to keep communication channels open. The human relationship is an encounter, an act of mutual identity-giving. Alzheimer-patient identity break-down is linked to cognitive troubles and to the failure of patients’ relationship attempts.
文摘A regional map of mangrove forests was produced for six islands located in the southern part of Japan by integrating the spectral analyses of Landsat Enhanced Thematic Mapper plus (ETM+) images with a digital elevation model (DEM). Several attempts were applied to propose a reliable method, which can be used to map the distribution of mangrove forests at a regional scale. The methodology used in this study comprised of obtaining the difference between Normalized Difference Water Index (NDWI) and Normalized Difference Vegetation Index (NDVI), band ratio 5/4, and band 5, from Landsat ETM+, and integrating them with the topographic information. The integration of spectral analyses with topographic data has clearly separated the mangrove forests from other vegetation. An accuracy assessment was carried out in order to check the accuracy of the results. High overall accuracy ranging from 89.3% to 93.6% was achieved, which increased the opportunity to use this methodology in other countries rich in mangrove forests.
文摘Alzheimer’s Disease (AD) is a neurodegenerative illness with frequency of occurrence increasing with old age. If memory impairment setting progressively is here an element associated upfront, other neurocognitive troubles are also associated, for example, language impairment which can degenerate into aphasia. Aim of the study. To evaluate semantic and textual impairment in AD. Methods. Populations studied concerned 151 AD patients in consultation at Brest University Hospital. Certain sociodemographic data (sex, age, cultural levels) were collected as well as results from neuropsychological tests: (Folstein-MMSE;Dubois’s 5-word test;fluencies, Dubois’ s frontal test battery;Cornell’s scale for depression;Barbizet’s test, “The Lion’s tale”, for textual analysis. Demented patients were composed of 102 females and 49 males of average age 80.3 ± 6.91. All the tests, including the number of items memorized latterly in the Barbizet’s test are impaired all the more by Folstein’s test being altered. The formal fluency on demented patients is less impaired than the semantic lexical fluency test (scored respectively 5.74 ± 1. 09 versus 4.41 ± 2. 19;t = 5.60, p < 0.01). The studied demented cohort shows more intrusions (n = 36) than inversions in the delayed Lion’s tale, whether for items or for episodes in which they occur (n = 19). The regressive PLS analysis shows that for the explanation of the overall scores to do with “The lion’s tale”, calculated later, only attainment of formal fluency has any notable influence (Regression coefficient CR = 0.224) or, more accessorily, the cultural level (CR = 0.12). Conclusions: Attainment of category fluency and patient culture levels has effects on narrativity.
基金Supported by the Special Funds for the Major State Basic Research Project (973) (Grant No. G2000077900)the High-Tech Research and Development Program of China (Grant No. 2001AA135110)EAGLE (Exploitation of AnGular Effects in Land Surface Observation From Satellites in the Sixth Framework Program (FP6) of EU) (Grant No. SST3CT2003502057)
文摘In this paper, a new method for canopy water content (FMC) estimation for highly vegetated surfaces- shortwave infrared perpendicular water stress index (SPSI) is developed using NIR, SWIR wavelengths of Enhanced Thematic Mapper Plus (ETM+) on the basis of spectral features and distribution of surface targets with different water conditions in NIR-SWIR spectral space. The developed method is further explored with radiative transfer simulations using PROSPECT, Lillesaeter, SailH and 6S. It is evident from the results of validation derived from satellite synchronous field measurements that SPSI is highly correlated with FMC, coefficient of determination (R squared) and root mean square error are 0.79 and 26.41%. The paper concludes that SPSI has a potential in vegetation water content estimation in terms of FMC.
基金the Spanish Ministry of Science and Innovation for the contract through the Ramón y Cajal(RYC-2009-03901) programthe support through the project of Protein Oxidation in Frozen Meat and Dry-Cured Products:Mechanisms+2 种基金Consequences and Development of Antioxidant Strategies(AGL2010-15134)The European Community(Research Executive Agency) is also acknowledged for the Marie Curie Reintegration Fellowship(PERG05-GA-2009-248959 Pox-MEAT)
文摘The efifciency of extracts from Arbutus unedo L. （AU）, Crataegus monogyna L. （CM）, Rosa canina L. （RC）, and Rubus ulmifolius Schott. （RU） to inhibit lipid oxidation in raw, cooked and cooked and chilled （2°C/12 d） porcine burger patties, was investigated. The modiifcation of the fatty acid proifle during processing treatments （cooking and chilling）, the quantitative measurements of thiobarbituric acid reactive substances （TBA-RS）, and lipid-derived volatiles, were used as indicators of lipid oxidation. Polyunsaturated fatty acids （PUFA） gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being signiifcantly greater （P〈0.05） in control patties than in those with added berry extracts. In accordance, the control patties showed signiifcantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts （P〈0.05）. Results from the present work show, for the ifrst time, that extracts from A. unedo, C. monogyna, R. canina, and R. ulmifolius are promising antioxidants which could enhance the nutritional, safety and sensory properties of porcine burger patties.
文摘近几十年来,全球生态系统、气候和生物多样性已不同程度受到人口快速增长和城市持续扩张带来的负面影响.使用低分辨率遥感影像数据和GIS技术定量分析了近40a全球城市时空变化.世界数字化图(Digital Chart of the World,DCW)城市图层代表1960年至1970年的全球城市面积,利用MODIS影像数据、稳定夜间光数据和城市格网人口密度数据编制的全球土地覆盖数据城市图(GlobalLand Cover by National Mapping Organization,GLCNMO)代表2003年时的全球城市面积.计算了1960年和2003年全球城市的城市用地比重和年城市增长率指数,从区域尺度、国家尺度和单个城市尺度分析了全球城市扩展的时空变化过程.结果表明:在1960年代发达国家城市面积较大,而发展中国家城市面积小得多;到2003年发展中国家有相当大的变化,新增长的城市区域快速扩大.近40a来发展中国家城市区域发展速度远快于发达国家,与欧洲和北美国家相比,发展中国家城市结构更紧凑和密集.
文摘Global land cover is one of the fundamental contents of Digital Earth.The Global Mapping project coordinated by the International Steering Committee for Global Mapping has produced a 1-km global land cover datasetGlobal Land Cover by National Mapping Organizations.It has 20 land cover classes defined using the Land Cover Classification System.Of them,14 classes were derived using supervised classification.The remaining six were classified independently:urban,tree open,mangrove,wetland,snow/ice,andwater.Primary source data of this land cover mapping were eight periods of 16-day composite 7-band 1-km MODIS data of 2003.Training data for supervised classification were collected using Landsat images,MODIS NDVI seasonal change patterns,Google Earth,Virtual Earth,existing regional maps,and expert’s comments.The overall accuracy is 76.5%and the overall accuracy with the weight of the mapped area coverage is 81.2%.The data are available from the Global Mapping project website(http://www.iscgm.org/).TheMODISdata used,land cover training data,and a list of existing regional maps are also available from the CEReS website.This mapping attempt demonstrates that training/validation data accumulation from different mapping projects must be promoted to support future global land cover mapping.
基金part of project Pathogen Combat(FP6-007081)funded under the Framework 6 Programme of the European Union
文摘Objective: To evaluate the potential of commercial fermented products sold in the country,and strains of Lactobacillus plantarum(L,plantarum)as prophylaxis and therapy against diarrhoea in children,Methods: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk(DLSM),Probrand sour milk(PSM),Kefalos Vuka cheese(KVC) and Chibuku opaque beer(COB); and four strains of L,plantarum obtained from Balkan traditional cheeses against clinical strains of Escherichia coli(E,coli) was assayed using the well diffusion method,Three commercial paediatric antidiarrhoeal drug products: Biogaia(BG),Prolife(PL) and Probio Junior(PJ) and a mutant strain of E,coli [strain 11105(ATCC)- a vitamin B-12 auxotroph and penicillin G acylase-producing strain] were used as controls,An agar diffusion assay and a competitive exclusion assay were carried out on Mueller Hinton agar,Results: Crude cultures of putative lactobacillus strains obtained from Zimbabwean dairy products(Probrand sour milk,Kefalos Vuka vuka cheese and Chibuku opaque beer) had significantly higher antimicrobial activities against clinical strains of E,coli than strains of L,plantarum isolated from Balkan cheeses(CLP1,CLP2 or CLP3) and crude microbial cultures from commercial paediatric probiotic products(BG,PJ and PL) of a culture of Lactobacillus rhamnosus LGG(P<0.05),Conclusions: The putative Lactobacilli from four commercial Zimbabwean dairy products(Probrand sour milk,Kefalos Vuka vuka cheese and Chibuku opaque beer),and three strains of L,plantarum from Balkan cheeses(CLP1,CLP2 or CLP3) exhibited high antibacterial activities that can be harnessed to control paediatric diarrhoea that is caused by pathogenic strains of E,coli,Studies to characterise the probiotic potential of the live cultures in the products and the new strains of L,plantarum are underway.
