Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the tr...Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,ie.jet-quenching.Previous measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au collisions.The modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching ef-fect.This paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle pr.The subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are described.The correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow backgrounds.The away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger particles.The near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately constant.The correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from fluc-tuations.It is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak structure.The dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open ques-tion.Even with aФ_(s)-dependent elliptic flow,the away-side correlation structure is robust.These results,with exte展开更多
This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multis...This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children.展开更多
目的调查乳腺癌患者术后不同程度淋巴水肿发生状况及其相关症状情况,分析两者之间的关系。方法采用便利抽样及目的抽样方法,选择乳腺癌行腋窝淋巴结清扫术后患者224例,采用肢体周径测量法判断淋巴水肿严重程度,采用乳腺癌淋巴水肿症状...目的调查乳腺癌患者术后不同程度淋巴水肿发生状况及其相关症状情况,分析两者之间的关系。方法采用便利抽样及目的抽样方法,选择乳腺癌行腋窝淋巴结清扫术后患者224例,采用肢体周径测量法判断淋巴水肿严重程度,采用乳腺癌淋巴水肿症状体验指数(Breast Cancer and Lymphedema Symptom Experience Index,BCLE-SEI)评估患者淋巴水肿相关症状体验。结果 224例患者中,无水肿94例(42.0%),轻度水肿46例(20.5%),重度水肿84例(37.5%)。轻度淋巴水肿患者的症状个数、症状严重程度及症状困扰总分高于无淋巴水肿患者(P=0.007);重度淋巴水肿患者的症状个数、症状严重程度及症状困扰总分高于轻度淋巴水肿患者(P=0.017)。轻度水肿患者的上肢肿胀、患肢沉重、患肢疲乏、患肢紧绷、患肢僵硬、手臂受限、肘部受限、手腕受限的发生率高于无水肿患者。结论淋巴水肿早期就出现相应症状,且症状体验随着水肿加重而越发严重。关注患肢肿胀、患肢沉重等淋巴液积聚症状,可早期发现淋巴水肿并给予早期干预,阻止或延缓水肿程度的进展。展开更多
The basic reproduction number of an infectious agent is the average number of infections one case can generate over the course of the infectious period,in a naïve,uninfected population.It is well-known that the e...The basic reproduction number of an infectious agent is the average number of infections one case can generate over the course of the infectious period,in a naïve,uninfected population.It is well-known that the estimation of this number may vary due to several methodological issues,including different assumptions and choice of parameters,utilized models,used datasets and estimation period.With the spreading of the novel coronavirus(2019-nCoV)infection,the reproduction number has been found to vary,reflecting the dynamics of transmission of the coronavirus outbreak as well as the case reporting rate.Due to significant variations in the control strategies,which have been changing over time,and thanks to the introduction of detection technologies that have been rapidly improved,enabling to shorten the time from infection/symptoms onset to diagnosis,leading to faster confirmation of the new coronavirus cases,our previous estimations on the transmission risk of the 2019-nCoV need to be revised.By using time-dependent contact and diagnose rates,we refit our previously proposed dynamics transmission model to the data available until January 29th,2020 and re-estimated the effective daily reproduction ratio that better quantifies the evolution of the interventions.We estimated when the effective daily reproduction ratio has fallen below 1 and when the epidemics will peak.Our updated findings suggest that the best measure is persistent and strict self-isolation.The epidemics will continue to grow,and can peak soon with the peak time depending highly on the public health interventions practically implemented.展开更多
The Global boundary Stratotype Section and Point （GSSP） for the base of the Hirnantian Stage （the uppermost of the Ordovician System） is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangj...The Global boundary Stratotype Section and Point （GSSP） for the base of the Hirnantian Stage （the uppermost of the Ordovician System） is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North section. The section is located near Wangjiawan village, 42 km north of Yichang city （western Hubei, China）, at 30° 58′56″N and 111° 25′10″E. The GSSP level coincides with the first appearance of the graptolite species Normalograptus extraordinarius （Sobolevskaya）. Secondary markers include the onset of a positive carbon-isotope excursion, and a slightly earlier first appearance of Normalograptus ojsuensis （ Koren and Mikhailova ）. The Wangjiawan North section possesses continuity of sedimentation and biozonation with completeness of exposures, abundant and well-preserved graptolites and shelly fossils, i. e. the Hirnantia- Dalmanitina shelly fauna which is a key element for recognition of the Hirnantian Stage. The Wangjiawan North, South and Riverside sections possess favorable facies and widespread correlation potential, are free from structure complication, metamorphism and other alteration, and have good accessibility. The Riverside section in particular possesses amenability to isotopic age determination. The beginning of the Hirnantian was followed by a global episode of a major extinction event, which happened in the Diceratograptus mirus Subzone. The proposal was voted by the International Subcommission on Ordovician Stratigraphy in October, 2004, approved by the International Commission on Stratigraphy in February, 2006, and ratified by the International Union of Geological Sciences in May, 2006.展开更多
Detecting and segmenting salient objects from natural scenes, often referred to as salient object detection, has attracted great interest in computer vision. While many models have been proposed and several applicatio...Detecting and segmenting salient objects from natural scenes, often referred to as salient object detection, has attracted great interest in computer vision. While many models have been proposed and several applications have emerged, a deep understanding of achievements and issues remains lacking. We aim to provide a comprehensive review of recent progress in salient object detection and situate this field among other closely related areas such as generic scene segmentation, object proposal generation, and saliency for fixation prediction. Covering 228 publications, we survey i) roots, key concepts, and tasks, ii) core techniques and main modeling trends, and iii) datasets and evaluation metrics for salient object detection. We also discuss open problems such as evaluation metrics and dataset bias in model performance, and suggest future research directions.展开更多
Nitrogen （N） is an essential macronutrient that affects plant growth and development. N is an important component of chlorophyll, amino acids, nucleic acids, and secondary metabolites. Nitrate is one of the most abu...Nitrogen （N） is an essential macronutrient that affects plant growth and development. N is an important component of chlorophyll, amino acids, nucleic acids, and secondary metabolites. Nitrate is one of the most abundant N sources in the soil. Because nitrate and other N nutrients are often limiting, plants have developed sophisticated mechanisms to ensure adequate supply of nutrients in a variable environment. Nitrate is absorbed in the root and mobilized to other organs by nitrate transporters. Nitrate sensing activates signaling pathways that impinge upon molecular, metabolic, physiological, and developmental responses locally and at the whole plant level. With the advent of genomics technologies and genetic tools, important advances in our understanding of nitrate and other N nutrient responses have been achieved in the past decade. Furthermore, techniques that take advantage of natural polymor- phisms present in divergent individuals from a single species have been essential in uncovering new components. However, there are still gaps in our understanding of how nitrate signaling affects biolog- ical processes in plants. Moreover, we still lack an integrated view of how all the regulatory factors iden- tified interact or crosstalk to orchestrate the myriad N responses plants typically exhibit. In this review, we provide an updated overview of mechanisms by which nitrate is sensed and transported throughout the plant. We discuss signaling components and how nitrate sensing crosstalks with hormonal pathways for developmental responses locally and globally in the plant. Understanding how nitrate impacts on plant metabolism, physiology, and growth and development in plants is key to improving crops for sustainable agriculture.展开更多
The red blood cell distribution width(RDW) is a simple, rapid, inexpensive and straightforward hematological parameter, reflecting the degree of anisocytosis in vivo. The currently available scientific evidence sugges...The red blood cell distribution width(RDW) is a simple, rapid, inexpensive and straightforward hematological parameter, reflecting the degree of anisocytosis in vivo. The currently available scientific evidence suggests that RDW assessment not only predicts the risk of adverse outcomes(cardiovascular and all-cause mortality, hospitalization for acute decompensation or worsened left ventricular function) in patients with acute and chronic heart failure(HF), but is also a significant and independent predictor of developing HF in patients free of this condition. Regarding the biological interplay between impaired hematopoiesis and cardiac dysfunction, many of the different conditions associated with increased heterogeneity of erythrocyte volume(i.e., ageing, inflammation, oxidative stress, nutritional deficiencies and impaired renal function), may be concomitantly present in patients with HF, whilst anisocytosis may also directly contribute to the development and worsening of HF. In conclusion, the longitudinal assessment of RDW changes over time may be considered an efficient measure to help predicting the risk of both development and progression of HF.展开更多
The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative ...The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection.展开更多
基金Supported in part by the Offices of NP and HEP within the U.S.DOE Office of Sciencethe U.S.NSF+18 种基金the Sloan Foundationthe DFG cluster of excellence‘Origin and Structure of the Universe’of Germany,CNRS/IN2P3STFC and EPSRC of the United KingdomFAPESP CNPq of Brazil,Ministry of Ed.Sci.of the Russian FederationNNSFCCASMoSTMoE of ChinaGA and MSMT of the Czech RepublicFOM and NWO of the NetherlandsDAEDSTCSIR of IndiaPolish Ministry of Sci.Higher Ed.,Korea Research Foundation,Ministry of Sci.,Ed.Sports of the Rep.Of CroatiaRussian Ministry of Sci.and TechRos-Atom of Russia。
文摘Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,ie.jet-quenching.Previous measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au collisions.The modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching ef-fect.This paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle pr.The subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are described.The correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow backgrounds.The away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger particles.The near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately constant.The correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from fluc-tuations.It is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak structure.The dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open ques-tion.Even with aФ_(s)-dependent elliptic flow,the away-side correlation structure is robust.These results,with exte
基金supported by the National Health Commission of the People’s Republic of China (201302002,Clinical Trial NCT02200679)。
文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children.
文摘目的调查乳腺癌患者术后不同程度淋巴水肿发生状况及其相关症状情况,分析两者之间的关系。方法采用便利抽样及目的抽样方法,选择乳腺癌行腋窝淋巴结清扫术后患者224例,采用肢体周径测量法判断淋巴水肿严重程度,采用乳腺癌淋巴水肿症状体验指数(Breast Cancer and Lymphedema Symptom Experience Index,BCLE-SEI)评估患者淋巴水肿相关症状体验。结果 224例患者中,无水肿94例(42.0%),轻度水肿46例(20.5%),重度水肿84例(37.5%)。轻度淋巴水肿患者的症状个数、症状严重程度及症状困扰总分高于无淋巴水肿患者(P=0.007);重度淋巴水肿患者的症状个数、症状严重程度及症状困扰总分高于轻度淋巴水肿患者(P=0.017)。轻度水肿患者的上肢肿胀、患肢沉重、患肢疲乏、患肢紧绷、患肢僵硬、手臂受限、肘部受限、手腕受限的发生率高于无水肿患者。结论淋巴水肿早期就出现相应症状,且症状体验随着水肿加重而越发严重。关注患肢肿胀、患肢沉重等淋巴液积聚症状,可早期发现淋巴水肿并给予早期干预,阻止或延缓水肿程度的进展。
基金This research was funded by the National Natural Science Foundation of China(grant numbers:11631012(YX,ST),61772017(ST))by the Canada Research Chair Program(grant number:230720(JW)the Natural Sciences and Engineering Research Council of Canada(Grant number:105588-2011(JW).
文摘The basic reproduction number of an infectious agent is the average number of infections one case can generate over the course of the infectious period,in a naïve,uninfected population.It is well-known that the estimation of this number may vary due to several methodological issues,including different assumptions and choice of parameters,utilized models,used datasets and estimation period.With the spreading of the novel coronavirus(2019-nCoV)infection,the reproduction number has been found to vary,reflecting the dynamics of transmission of the coronavirus outbreak as well as the case reporting rate.Due to significant variations in the control strategies,which have been changing over time,and thanks to the introduction of detection technologies that have been rapidly improved,enabling to shorten the time from infection/symptoms onset to diagnosis,leading to faster confirmation of the new coronavirus cases,our previous estimations on the transmission risk of the 2019-nCoV need to be revised.By using time-dependent contact and diagnose rates,we refit our previously proposed dynamics transmission model to the data available until January 29th,2020 and re-estimated the effective daily reproduction ratio that better quantifies the evolution of the interventions.We estimated when the effective daily reproduction ratio has fallen below 1 and when the epidemics will peak.Our updated findings suggest that the best measure is persistent and strict self-isolation.The epidemics will continue to grow,and can peak soon with the peak time depending highly on the public health interventions practically implemented.
文摘The Global boundary Stratotype Section and Point （GSSP） for the base of the Hirnantian Stage （the uppermost of the Ordovician System） is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North section. The section is located near Wangjiawan village, 42 km north of Yichang city （western Hubei, China）, at 30° 58′56″N and 111° 25′10″E. The GSSP level coincides with the first appearance of the graptolite species Normalograptus extraordinarius （Sobolevskaya）. Secondary markers include the onset of a positive carbon-isotope excursion, and a slightly earlier first appearance of Normalograptus ojsuensis （ Koren and Mikhailova ）. The Wangjiawan North section possesses continuity of sedimentation and biozonation with completeness of exposures, abundant and well-preserved graptolites and shelly fossils, i. e. the Hirnantia- Dalmanitina shelly fauna which is a key element for recognition of the Hirnantian Stage. The Wangjiawan North, South and Riverside sections possess favorable facies and widespread correlation potential, are free from structure complication, metamorphism and other alteration, and have good accessibility. The Riverside section in particular possesses amenability to isotopic age determination. The beginning of the Hirnantian was followed by a global episode of a major extinction event, which happened in the Diceratograptus mirus Subzone. The proposal was voted by the International Subcommission on Ordovician Stratigraphy in October, 2004, approved by the International Commission on Stratigraphy in February, 2006, and ratified by the International Union of Geological Sciences in May, 2006.
基金support ongoing meetings was provided by ISPOR-The Professional Society for Health Economics and Outcomes ResearchThe funders had no role in considering the study design or in the collection,analysis,interpretation of data,or writing of the report.Funding for DH and the Delphi Panel exercise was provided by 9363980 Canada Ine+1 种基金the NIHR Applied Research Collaboration(ARC)West Midlandsthe NIHR Health Protection Research Unit(HPRU)Gastrointestinal Infections,and the NIHR HPRU Genomics and Enabling data.
文摘Detecting and segmenting salient objects from natural scenes, often referred to as salient object detection, has attracted great interest in computer vision. While many models have been proposed and several applications have emerged, a deep understanding of achievements and issues remains lacking. We aim to provide a comprehensive review of recent progress in salient object detection and situate this field among other closely related areas such as generic scene segmentation, object proposal generation, and saliency for fixation prediction. Covering 228 publications, we survey i) roots, key concepts, and tasks, ii) core techniques and main modeling trends, and iii) datasets and evaluation metrics for salient object detection. We also discuss open problems such as evaluation metrics and dataset bias in model performance, and suggest future research directions.
文摘Nitrogen （N） is an essential macronutrient that affects plant growth and development. N is an important component of chlorophyll, amino acids, nucleic acids, and secondary metabolites. Nitrate is one of the most abundant N sources in the soil. Because nitrate and other N nutrients are often limiting, plants have developed sophisticated mechanisms to ensure adequate supply of nutrients in a variable environment. Nitrate is absorbed in the root and mobilized to other organs by nitrate transporters. Nitrate sensing activates signaling pathways that impinge upon molecular, metabolic, physiological, and developmental responses locally and at the whole plant level. With the advent of genomics technologies and genetic tools, important advances in our understanding of nitrate and other N nutrient responses have been achieved in the past decade. Furthermore, techniques that take advantage of natural polymor- phisms present in divergent individuals from a single species have been essential in uncovering new components. However, there are still gaps in our understanding of how nitrate signaling affects biolog- ical processes in plants. Moreover, we still lack an integrated view of how all the regulatory factors iden- tified interact or crosstalk to orchestrate the myriad N responses plants typically exhibit. In this review, we provide an updated overview of mechanisms by which nitrate is sensed and transported throughout the plant. We discuss signaling components and how nitrate sensing crosstalks with hormonal pathways for developmental responses locally and globally in the plant. Understanding how nitrate impacts on plant metabolism, physiology, and growth and development in plants is key to improving crops for sustainable agriculture.
文摘The red blood cell distribution width(RDW) is a simple, rapid, inexpensive and straightforward hematological parameter, reflecting the degree of anisocytosis in vivo. The currently available scientific evidence suggests that RDW assessment not only predicts the risk of adverse outcomes(cardiovascular and all-cause mortality, hospitalization for acute decompensation or worsened left ventricular function) in patients with acute and chronic heart failure(HF), but is also a significant and independent predictor of developing HF in patients free of this condition. Regarding the biological interplay between impaired hematopoiesis and cardiac dysfunction, many of the different conditions associated with increased heterogeneity of erythrocyte volume(i.e., ageing, inflammation, oxidative stress, nutritional deficiencies and impaired renal function), may be concomitantly present in patients with HF, whilst anisocytosis may also directly contribute to the development and worsening of HF. In conclusion, the longitudinal assessment of RDW changes over time may be considered an efficient measure to help predicting the risk of both development and progression of HF.
基金supported by the NIH grants(R01AI137472 and R01AI139092)intramural funds of the New York Blood Center(VIM-NYB616 and CFM-NYB595).
文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection.
