Red blood cell(RBC)aggregation as well as their deformation significantly affects blood microrheology.These processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signali...Red blood cell(RBC)aggregation as well as their deformation significantly affects blood microrheology.These processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signaling molecule in the bloodstream.The purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells(RBCs)in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in vitro.Microrheological properties were measured using laser aggregometer and ektacytometer based on diffuse light scattering and diffraction of laser light on a suspension of RBCs,respectively.The study found that heparin-stabilized blood showed increased RBC aggregation and deformation with sodium nitroprusside concentrations of 100,and 200M,while EDTA-stabilized blood showed slightly decreased aggregation and unchanged deformation.With washed RBCs in dextran solution,the addition of sodium nitroprusside(in the concentrations of 100,and 200M)resulted in decreased aggregation and increased deformation.These-ndings aid in our understanding of nitric oxide's effect on RBC microrheological properties.展开更多
Red blood cells(RBCs)are the most abundant human blood cells.RBC aggregation and deformation strongly determine blood viscosity which impacts hemorheology and microcirculation.In turn,RBC properties depend on di®...Red blood cells(RBCs)are the most abundant human blood cells.RBC aggregation and deformation strongly determine blood viscosity which impacts hemorheology and microcirculation.In turn,RBC properties depend on di®erent endogenous and exogenous factors.One such factor is nitric oxide(NO),which is mainly produced by endothelial cells(EC)from L-arginine amino acid in the circulatory system.Since the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The effect of L-arginine induced NO on RBC aggregation and adhesion to endothelium;(2)the NO e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the samples.The RBC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the flow chamber method and Myrenne aggregometer.We confirmed that NO increases deformability and decreases aggregation of RBCs.We showed that the soluble guanylate cyclase pathway appears to be the only NO signaling pathway involved.In the samples with the endothelium,the "bell-shaped"dependence of RBC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of NO production by endothelium.Additionally,data related to L-arginine accumulation by endothelium were obtained:Necessity of the presence of extracellular L-arginine stated by other authors was put under question.In our study,NO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not confirmed in another set of experiments.To our knowledge,this is the first attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.展开更多
BACKGROUND Oral treatment of glucosamine(GA) combined with chondroitin sulfate(CS) was reportedly effective for pain relief and function improvement in osteoarthritis patients with moderate to severe knee pain in clin...BACKGROUND Oral treatment of glucosamine(GA) combined with chondroitin sulfate(CS) was reportedly effective for pain relief and function improvement in osteoarthritis patients with moderate to severe knee pain in clinical trials. While the effectiveness of GA and CS on both clinical and radiological findings has been demonstrated, only a few high-quality trials exist. Therefore, controversy regarding their effectiveness in real-world clinical practice remains.AIM To investigate the impact of GA + CS on clinical outcomes of patients with knee and hip osteoarthritis in routine clinical practice.METHODS A multicenter prospective observational cohort study included 1102 patients of both genders with knee or hip osteoarthritis(Kellgren & Lawrence grades Ⅰ-Ⅲ) in 51 clinical centers in the Russian Federation from November 20, 2017, to March 20,2020, who had started to receive oral capsules of glucosamine hydrochloride 500 mg and CS 400mg according to the approved patient information leaflet starting from 3 capsules daily for 3 wk,followed by a reduced dosage of 2 capsules daily before study inclusion(minimal recommended treatment duration is 3-6 mo). Changes in subscale scores [Pain, Symptoms, Function, and Quality of Life(QOL)] of the Knee Injury and Osteoarthritis Outcome Score(KOOS)/Hip Disability and Osteoarthritis Outcome Score(HOOS) questionnaires during the observational period(up to 54-64wk with a total of 4 visits). Patients’ treatment satisfaction, data on the combined oral use of glucosamine hydrochloride and CS, concomitant use of non-steroidal anti-inflammatory drugs(NSAIDs), and adverse events(AEs) were also evaluated.RESULTS A total of 1102 patients with knee and hip osteoarthritis were included in the study. The mean patient age was 60.4 years, most patients were women(87.8%), and their average body mass index was 29.49 kg/m2. All subscale scores(Pain, Symptoms, Function, and QOL) of the KOOS and HOOS demonstrated clinically and statistically significant improvements. In patients with knee osteoart展开更多
In a model based on a search with increased accuracy of calculations-four times-of all the roots of the equations for the velocities of electrons in the inverse Compton effect,it is established that for new values of ...In a model based on a search with increased accuracy of calculations-four times-of all the roots of the equations for the velocities of electrons in the inverse Compton effect,it is established that for new values of the roots of the equations(corresponding to the laws of conservation of momentum and energy),the recoil electrons remain ultra-relativistic,according to the authors,allows to eliminate the reverse Compton catastrophe of quasars.The maximum value of the scattering angle of the formed particles was found to explain the thin quasar jets.展开更多
Background: There is a necessity for an establishment of specific markers of oxidative stress for screening in populations of high risk and an estimation of efficiency antioxidative therapies. Objective: Studying the ...Background: There is a necessity for an establishment of specific markers of oxidative stress for screening in populations of high risk and an estimation of efficiency antioxidative therapies. Objective: Studying the activity of antioxidative enzymes at neutrophils in patients with acute coronary syndrome depending on outcome during the year. Methods: Intracellular metabolism of neutrophils was studied in 108 patients, of whom, in 58 persons has been diagnosed acute coronary syndrome, and 50 individuals were without coronary heart disease. Results: In patients with acute coronary syndrome, in comparison with patients without coronary heart disease, growth of production of superoxide anion on background reduction of glutathione reductase activity in neutrophils was revealed. The greatest reduction in parameters of glutathione reductase and catalase at simultaneous growth of activity of NAD(P)H oxidase and myeloperoxidase at neutrophils was observed in patients with fatal outcome during the year. Conclusion: The decrease of efficiency antioxidative protection of neutrophils associates with risk of fatal outcome in patients with acute coronary syndrome.展开更多
Our studies allowed us to establish that simulating coarctation of aorta in laboratory animals results in tone reduction of vessels carrying blood to the liver and from it and a subsequent development of their intima ...Our studies allowed us to establish that simulating coarctation of aorta in laboratory animals results in tone reduction of vessels carrying blood to the liver and from it and a subsequent development of their intima atrophy. In spite of that fact the number of vessels containing intimal musculature, muscularelastic sphincters and polypoid pulvini in the arterial bed flow increases and in the major outflowing veins, on the contrary, thinning of their muscular tori takes place. Appearance and functioning in the hepatic vessels of adaptive formations contributes to keeping up homeostasis at the microcirculatory level. With cardiac decompensation decreasing because of venous plethora, hypotonia and atrophy of the intima of the vessels responsible for the blood inflow to the liver and the outflow from it progress. Besides, the number of arteries and the rate of development of arteries with adaptive smooth muscle formations in the arteries, as well as in hepatic veins with muscular tori decreases dramatically. The reason of compensatory reaction failure is a long-term hypoxia leading to vessel and their adaptive formation sclerosis. The consequence of the exhaustion of the above-mentioned mechanisms is development of perisinusoidal fibrosis and depression of the transcapillary metabolism.展开更多
Background: The factor promoting development of oxidative stress at obesity can be the neutro-phils. Objective: To study the influence antirisk factors of cardiovascular diseases on intracellular metabolism of neutrop...Background: The factor promoting development of oxidative stress at obesity can be the neutro-phils. Objective: To study the influence antirisk factors of cardiovascular diseases on intracellular metabolism of neutrophils in men with peripheral obesity. Methods: In 103 male patients aged 23 to 64 years without coronary heart disease, we studied the presence obesity, antirisk factors of cardiovascular diseases, and the metabolic activity of neutrophils. Results: It is identified that obesity in men associates with more rare use of crude vegetables or fruits every day, and also low physical activity. The daily uses of crude vegetables or fruits, and also the increase of physical activity in obese men promote increase intracellular activity of antioxidative protection at neutrophils. Conclusion: The antirisk factors of cardiovascular diseases increase activity antioxidative protection of neutrophils in men with peripheral obesity, reducing the probability of development of oxidative stress.展开更多
The paper deals with the performing of a critical analysis of the problems arising in matching the classical models of the statistical and phenomenological thermodynamics. The performed analysis shows that some concep...The paper deals with the performing of a critical analysis of the problems arising in matching the classical models of the statistical and phenomenological thermodynamics. The performed analysis shows that some concepts of the statistical and phenomenological methods of describing the classical systems do not quite correlate with each other. Particularly, in these methods various caloric ideal gas equations of state are employed, while the possibility existing in the thermodynamic cyclic processes to obtain the same distributions both due to a change of the particle concentration and owing to a change of temperature is not allowed for in the statistical methods. The above-mentioned difference of the equations of state is cleared away when using in the statistical functions corresponding to the canonical Gibbs equations instead of the Planck’s constant a new scale factor that depends on the parameters of a system and coincides with the Planck’s constant in going of the system to the degenerate state. Under such an approach, the statistical entropy is transformed into one of the forms of heat capacity. In its turn, the agreement of the methods under consideration in the question as to the dependence of the molecular distributions on the concentration of particles, apparently, will call for further refinement of the physical model of ideal gas and the techniques for its statistical description.展开更多
This is a survey of some recent progress in the theory of groups with factorizations. Some of the methods can be used to obtain information about finite groups in general, nilpotent algebras and nearrings.
Background: Early disturbances of carbohydrate metabolism are an independent risk factor of development of cardiovascular diseases. Objective: The diastolic dysfunction and left ventricle remodeling depending on prese...Background: Early disturbances of carbohydrate metabolism are an independent risk factor of development of cardiovascular diseases. Objective: The diastolic dysfunction and left ventricle remodeling depending on presence of impaired fasting glucose were examined. Methods: The characteristics of heart remodeling and fasting glucose of capillary blood were studied in 85 men aged 30 to 63 years without coronary heart disease. Results: In male patients with impaired fasting glucose in comparison of persons with level of glucose less than 5.6 mM/l, more pronounced diastolic dysfunction and left ventricle remodeling associated with more often presence III degree of peripheral obesity. Conclusion: Impaired fasting glucose in men increases probability of development of heart remodeling.展开更多
Analysis of the safety and efficacy of the currently marked oral anticoagulants was performed in patients after large joints arthroplasty. A total of 5025 patients after total knee arthroplasty and 5216 patients after...Analysis of the safety and efficacy of the currently marked oral anticoagulants was performed in patients after large joints arthroplasty. A total of 5025 patients after total knee arthroplasty and 5216 patients after total hip arthroplasty were examined. All patients were divided into groups by the prescribed anticoagulant. The duration of anticoagulant therapy was 35 days and 6 weeks after surgery, respectively. Ultrasonography of the lower extremities veins was performed in all patients prior to the surgery and 5 days after surgery. In patients receiving Dabigatran, the incidence of clinically significant deep vein thrombosis was lower compared with patients receiving Rivaroxaban and Apixaban; in contrast, the rate of postoperative hematomas in the last two groups was higher.展开更多
The discrete three-dimensional model of the adsorption-diffusion process was developed with three states using the comers of blocks within the framework of the theory of CA （cellular automata）. The construction of a...The discrete three-dimensional model of the adsorption-diffusion process was developed with three states using the comers of blocks within the framework of the theory of CA （cellular automata）. The construction of an asynchronous cellular automaton was used for the modeling, The implementation of the algorithm leads to a huge variety of dynamical regimes some of which are moving from the general chaos into a state of local and then global synchronization （within the framework of the model）.展开更多
This paper is focused on the first study of microbiota of a moderate climate orchid from Northern hemisphere—Moorland Spotted Orchid Dactylorhiza maculata (L.) Soó growing in its natural habitat. There have been...This paper is focused on the first study of microbiota of a moderate climate orchid from Northern hemisphere—Moorland Spotted Orchid Dactylorhiza maculata (L.) Soó growing in its natural habitat. There have been obtained detailed data concerning bacterial communities from rhizosphere and inner tissues of young and old tubers. It was done using the biomarker analysis method where the markers were detected by gas chromatography—mass-spectrometry. It is shown that the number of bacterial genera and the bacteria amount (105 - 108 CFU per gram of dry weight) in D. maculata microbial complexes decreases from rhizosphere to old tuber to young. At the same time all three bacterial cenoses closely resemble each other in biodiversity. Their constant members are gg. Hyphomicrobium, Methylococcus, Nitrobacter, Pseudomonas and Sphingomonas (Proteobacteria), Bacillus and Clostridium (Firmicutes), Rhodococcus and Streptomyces (Actinobacteria). There were found differences peculiar to the taxonomic structure of each microbial complex. The rhizosphere is dominated by Actinobacteria while in inner tissues Proteobacteria are prevalent. The bacteria of gg. Ochrobactrum, Xanthomonas, Butyrivibrio, Corynebacterium, Mycobacterium, Propionibacterium, Sphingobacterium and specific iron reducers were shown to belong to rhizosphere community. Genera of Agrobacterium and Bifidobacterium were found only in the endophytic microbiota of the young tuber while g. Aeromonas展开更多
The pilot-scale process for preparing 2-amino-6-chloro-9-（2＇,3＇,5＇-tri-O-acetyl-Dq3-ribofuranosyl）-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respec...The pilot-scale process for preparing 2-amino-6-chloro-9-（2＇,3＇,5＇-tri-O-acetyl-Dq3-ribofuranosyl）-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respectively. These compounds are useful intermediates for enzymatic synthesis of active pharmaceutical ingredients Nelarabine and Cladribine. The starting material--commercially avaliable guanosine--was acetylated with acetic anhydride, yielding 2,3,5-tri-O-acetylguanosine, which was further deoxyhalogenated with phosphorous oxychloride in presence of tetraethylammonia chloride. Diazotization of the resulting intermediate with tert-butylnitrite leads to the corresponding ribofuranosyl-substituted 2,6-dichloropurine, which was converted to 6-chloroadenosine by reaction with methanolic ammonia.展开更多
This is a survey on the recent progress in the theory of finite groups with factorizations and around it,done by the author and his coauthors,and this has no pretensions to cover all topics in this wide area of resear...This is a survey on the recent progress in the theory of finite groups with factorizations and around it,done by the author and his coauthors,and this has no pretensions to cover all topics in this wide area of research.In particular,we only touch the great consequences of the fundamental paper of Liebeck,Praeger and Saxl on maximal factorizations of almost simple finite groups for the theory of groups with factorizations.In each case the reader can find additional references at the end of Section 1.Some of the methods of investigation can be used to obtain information about finite groups in general,nilpotent algebras and related nearrings.展开更多
基金supported by the Russian Science Foundation grant(No.22-15-00120)supported by the grant(No.21-2-10-59-1)from the Foundation for the Development of Theoretical Physics and Mathematics BASIS.
文摘Red blood cell(RBC)aggregation as well as their deformation significantly affects blood microrheology.These processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signaling molecule in the bloodstream.The purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells(RBCs)in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in vitro.Microrheological properties were measured using laser aggregometer and ektacytometer based on diffuse light scattering and diffraction of laser light on a suspension of RBCs,respectively.The study found that heparin-stabilized blood showed increased RBC aggregation and deformation with sodium nitroprusside concentrations of 100,and 200M,while EDTA-stabilized blood showed slightly decreased aggregation and unchanged deformation.With washed RBCs in dextran solution,the addition of sodium nitroprusside(in the concentrations of 100,and 200M)resulted in decreased aggregation and increased deformation.These-ndings aid in our understanding of nitric oxide's effect on RBC microrheological properties.
基金supported by the Russian Science Foundation Grant No.22-15-00120.
文摘Red blood cells(RBCs)are the most abundant human blood cells.RBC aggregation and deformation strongly determine blood viscosity which impacts hemorheology and microcirculation.In turn,RBC properties depend on di®erent endogenous and exogenous factors.One such factor is nitric oxide(NO),which is mainly produced by endothelial cells(EC)from L-arginine amino acid in the circulatory system.Since the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The effect of L-arginine induced NO on RBC aggregation and adhesion to endothelium;(2)the NO e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the samples.The RBC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the flow chamber method and Myrenne aggregometer.We confirmed that NO increases deformability and decreases aggregation of RBCs.We showed that the soluble guanylate cyclase pathway appears to be the only NO signaling pathway involved.In the samples with the endothelium,the "bell-shaped"dependence of RBC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of NO production by endothelium.Additionally,data related to L-arginine accumulation by endothelium were obtained:Necessity of the presence of extracellular L-arginine stated by other authors was put under question.In our study,NO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not confirmed in another set of experiments.To our knowledge,this is the first attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.
文摘BACKGROUND Oral treatment of glucosamine(GA) combined with chondroitin sulfate(CS) was reportedly effective for pain relief and function improvement in osteoarthritis patients with moderate to severe knee pain in clinical trials. While the effectiveness of GA and CS on both clinical and radiological findings has been demonstrated, only a few high-quality trials exist. Therefore, controversy regarding their effectiveness in real-world clinical practice remains.AIM To investigate the impact of GA + CS on clinical outcomes of patients with knee and hip osteoarthritis in routine clinical practice.METHODS A multicenter prospective observational cohort study included 1102 patients of both genders with knee or hip osteoarthritis(Kellgren & Lawrence grades Ⅰ-Ⅲ) in 51 clinical centers in the Russian Federation from November 20, 2017, to March 20,2020, who had started to receive oral capsules of glucosamine hydrochloride 500 mg and CS 400mg according to the approved patient information leaflet starting from 3 capsules daily for 3 wk,followed by a reduced dosage of 2 capsules daily before study inclusion(minimal recommended treatment duration is 3-6 mo). Changes in subscale scores [Pain, Symptoms, Function, and Quality of Life(QOL)] of the Knee Injury and Osteoarthritis Outcome Score(KOOS)/Hip Disability and Osteoarthritis Outcome Score(HOOS) questionnaires during the observational period(up to 54-64wk with a total of 4 visits). Patients’ treatment satisfaction, data on the combined oral use of glucosamine hydrochloride and CS, concomitant use of non-steroidal anti-inflammatory drugs(NSAIDs), and adverse events(AEs) were also evaluated.RESULTS A total of 1102 patients with knee and hip osteoarthritis were included in the study. The mean patient age was 60.4 years, most patients were women(87.8%), and their average body mass index was 29.49 kg/m2. All subscale scores(Pain, Symptoms, Function, and QOL) of the KOOS and HOOS demonstrated clinically and statistically significant improvements. In patients with knee osteoart
文摘In a model based on a search with increased accuracy of calculations-four times-of all the roots of the equations for the velocities of electrons in the inverse Compton effect,it is established that for new values of the roots of the equations(corresponding to the laws of conservation of momentum and energy),the recoil electrons remain ultra-relativistic,according to the authors,allows to eliminate the reverse Compton catastrophe of quasars.The maximum value of the scattering angle of the formed particles was found to explain the thin quasar jets.
文摘Background: There is a necessity for an establishment of specific markers of oxidative stress for screening in populations of high risk and an estimation of efficiency antioxidative therapies. Objective: Studying the activity of antioxidative enzymes at neutrophils in patients with acute coronary syndrome depending on outcome during the year. Methods: Intracellular metabolism of neutrophils was studied in 108 patients, of whom, in 58 persons has been diagnosed acute coronary syndrome, and 50 individuals were without coronary heart disease. Results: In patients with acute coronary syndrome, in comparison with patients without coronary heart disease, growth of production of superoxide anion on background reduction of glutathione reductase activity in neutrophils was revealed. The greatest reduction in parameters of glutathione reductase and catalase at simultaneous growth of activity of NAD(P)H oxidase and myeloperoxidase at neutrophils was observed in patients with fatal outcome during the year. Conclusion: The decrease of efficiency antioxidative protection of neutrophils associates with risk of fatal outcome in patients with acute coronary syndrome.
文摘Our studies allowed us to establish that simulating coarctation of aorta in laboratory animals results in tone reduction of vessels carrying blood to the liver and from it and a subsequent development of their intima atrophy. In spite of that fact the number of vessels containing intimal musculature, muscularelastic sphincters and polypoid pulvini in the arterial bed flow increases and in the major outflowing veins, on the contrary, thinning of their muscular tori takes place. Appearance and functioning in the hepatic vessels of adaptive formations contributes to keeping up homeostasis at the microcirculatory level. With cardiac decompensation decreasing because of venous plethora, hypotonia and atrophy of the intima of the vessels responsible for the blood inflow to the liver and the outflow from it progress. Besides, the number of arteries and the rate of development of arteries with adaptive smooth muscle formations in the arteries, as well as in hepatic veins with muscular tori decreases dramatically. The reason of compensatory reaction failure is a long-term hypoxia leading to vessel and their adaptive formation sclerosis. The consequence of the exhaustion of the above-mentioned mechanisms is development of perisinusoidal fibrosis and depression of the transcapillary metabolism.
文摘Background: The factor promoting development of oxidative stress at obesity can be the neutro-phils. Objective: To study the influence antirisk factors of cardiovascular diseases on intracellular metabolism of neutrophils in men with peripheral obesity. Methods: In 103 male patients aged 23 to 64 years without coronary heart disease, we studied the presence obesity, antirisk factors of cardiovascular diseases, and the metabolic activity of neutrophils. Results: It is identified that obesity in men associates with more rare use of crude vegetables or fruits every day, and also low physical activity. The daily uses of crude vegetables or fruits, and also the increase of physical activity in obese men promote increase intracellular activity of antioxidative protection at neutrophils. Conclusion: The antirisk factors of cardiovascular diseases increase activity antioxidative protection of neutrophils in men with peripheral obesity, reducing the probability of development of oxidative stress.
文摘The paper deals with the performing of a critical analysis of the problems arising in matching the classical models of the statistical and phenomenological thermodynamics. The performed analysis shows that some concepts of the statistical and phenomenological methods of describing the classical systems do not quite correlate with each other. Particularly, in these methods various caloric ideal gas equations of state are employed, while the possibility existing in the thermodynamic cyclic processes to obtain the same distributions both due to a change of the particle concentration and owing to a change of temperature is not allowed for in the statistical methods. The above-mentioned difference of the equations of state is cleared away when using in the statistical functions corresponding to the canonical Gibbs equations instead of the Planck’s constant a new scale factor that depends on the parameters of a system and coincides with the Planck’s constant in going of the system to the degenerate state. Under such an approach, the statistical entropy is transformed into one of the forms of heat capacity. In its turn, the agreement of the methods under consideration in the question as to the dependence of the molecular distributions on the concentration of particles, apparently, will call for further refinement of the physical model of ideal gas and the techniques for its statistical description.
文摘This is a survey of some recent progress in the theory of groups with factorizations. Some of the methods can be used to obtain information about finite groups in general, nilpotent algebras and nearrings.
文摘Background: Early disturbances of carbohydrate metabolism are an independent risk factor of development of cardiovascular diseases. Objective: The diastolic dysfunction and left ventricle remodeling depending on presence of impaired fasting glucose were examined. Methods: The characteristics of heart remodeling and fasting glucose of capillary blood were studied in 85 men aged 30 to 63 years without coronary heart disease. Results: In male patients with impaired fasting glucose in comparison of persons with level of glucose less than 5.6 mM/l, more pronounced diastolic dysfunction and left ventricle remodeling associated with more often presence III degree of peripheral obesity. Conclusion: Impaired fasting glucose in men increases probability of development of heart remodeling.
文摘Analysis of the safety and efficacy of the currently marked oral anticoagulants was performed in patients after large joints arthroplasty. A total of 5025 patients after total knee arthroplasty and 5216 patients after total hip arthroplasty were examined. All patients were divided into groups by the prescribed anticoagulant. The duration of anticoagulant therapy was 35 days and 6 weeks after surgery, respectively. Ultrasonography of the lower extremities veins was performed in all patients prior to the surgery and 5 days after surgery. In patients receiving Dabigatran, the incidence of clinically significant deep vein thrombosis was lower compared with patients receiving Rivaroxaban and Apixaban; in contrast, the rate of postoperative hematomas in the last two groups was higher.
文摘The discrete three-dimensional model of the adsorption-diffusion process was developed with three states using the comers of blocks within the framework of the theory of CA （cellular automata）. The construction of an asynchronous cellular automaton was used for the modeling, The implementation of the algorithm leads to a huge variety of dynamical regimes some of which are moving from the general chaos into a state of local and then global synchronization （within the framework of the model）.
文摘This paper is focused on the first study of microbiota of a moderate climate orchid from Northern hemisphere—Moorland Spotted Orchid Dactylorhiza maculata (L.) Soó growing in its natural habitat. There have been obtained detailed data concerning bacterial communities from rhizosphere and inner tissues of young and old tubers. It was done using the biomarker analysis method where the markers were detected by gas chromatography—mass-spectrometry. It is shown that the number of bacterial genera and the bacteria amount (105 - 108 CFU per gram of dry weight) in D. maculata microbial complexes decreases from rhizosphere to old tuber to young. At the same time all three bacterial cenoses closely resemble each other in biodiversity. Their constant members are gg. Hyphomicrobium, Methylococcus, Nitrobacter, Pseudomonas and Sphingomonas (Proteobacteria), Bacillus and Clostridium (Firmicutes), Rhodococcus and Streptomyces (Actinobacteria). There were found differences peculiar to the taxonomic structure of each microbial complex. The rhizosphere is dominated by Actinobacteria while in inner tissues Proteobacteria are prevalent. The bacteria of gg. Ochrobactrum, Xanthomonas, Butyrivibrio, Corynebacterium, Mycobacterium, Propionibacterium, Sphingobacterium and specific iron reducers were shown to belong to rhizosphere community. Genera of Agrobacterium and Bifidobacterium were found only in the endophytic microbiota of the young tuber while g. Aeromonas
文摘The pilot-scale process for preparing 2-amino-6-chloro-9-（2＇,3＇,5＇-tri-O-acetyl-Dq3-ribofuranosyl）-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respectively. These compounds are useful intermediates for enzymatic synthesis of active pharmaceutical ingredients Nelarabine and Cladribine. The starting material--commercially avaliable guanosine--was acetylated with acetic anhydride, yielding 2,3,5-tri-O-acetylguanosine, which was further deoxyhalogenated with phosphorous oxychloride in presence of tetraethylammonia chloride. Diazotization of the resulting intermediate with tert-butylnitrite leads to the corresponding ribofuranosyl-substituted 2,6-dichloropurine, which was converted to 6-chloroadenosine by reaction with methanolic ammonia.
文摘This is a survey on the recent progress in the theory of finite groups with factorizations and around it,done by the author and his coauthors,and this has no pretensions to cover all topics in this wide area of research.In particular,we only touch the great consequences of the fundamental paper of Liebeck,Praeger and Saxl on maximal factorizations of almost simple finite groups for the theory of groups with factorizations.In each case the reader can find additional references at the end of Section 1.Some of the methods of investigation can be used to obtain information about finite groups in general,nilpotent algebras and related nearrings.
