Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected monthly.This phase III trial study aimed to evaluated the efficacy and sa...Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected monthly.This phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate cancer.Methods:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in China.This study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three injections.The primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to 85.Non-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen levels.Results:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two groups.The cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).Both results met the criterion for non-inferiority.Secondary endpoints were similar between groups.Both treatments were well-tolerated.LY01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety profile.Trial registration:ClinicalTrials.gov,NCT04563936.展开更多
In recent years,flexible photodetectors(FPDs)have received increasing attention due to their applications in electronic eyes,flexible sensing,terminal devices,and wearable devices.In addition,metallic halide perovskit...In recent years,flexible photodetectors(FPDs)have received increasing attention due to their applications in electronic eyes,flexible sensing,terminal devices,and wearable devices.In addition,metallic halide perovskite materials are considered as future materials for FPDs due to their compatibility with flexible substrates,low cost,simple synthesis methods,and superior optoelectronic properties.This review provides a comprehensive overview of the relevant cutting-edge research in the field of flexible perovskite photodetectors(FPPDs)from 2020 to 2022.First,the evaluation criteria for FPPDs are discussed and the development of perovskite stability criteria is emphatically described.Afterwards,the synthesis methods and device construction processes of metal halide perovskite materials commonly used by researchers in the past three years are described.These include single crystals and low-dimensional materials.Moreover,we have elaborated on the research of self-powered FPPD and its contributions in wearability,terminals,and portability.Finally,a summary of developments and possibilities in the field of FPPDs from 2020 to 2022 is provided.展开更多
AZ91D alloy composites with1.0%CNTs have been fabricated by a method combined ball milling with stirring casting.The composite was investigated using optical microscopy(OM),X-ray diffraction(XRD),Fourier transform inf...AZ91D alloy composites with1.0%CNTs have been fabricated by a method combined ball milling with stirring casting.The composite was investigated using optical microscopy(OM),X-ray diffraction(XRD),Fourier transform infrared spectroscope(FT-IR),scanning electron microscope(SEM),transmission electron microscope(TEM)and room temperature(RT)tensile test.Theresults show that CNTs were homogeneously distributed in the matrix and maintained integrated structure.The yield strength andductility of AZ91D/CNTs composite were improved by47.2%and112.2%,respectively,when compared with the AZ91alloy.Theuniform distribution of CNTs and the strong interfacial bonds between CNT and the matrix are dominated to the simultaneousimprovement of yield strength and ductility of the composite.In addition,the grain refinement as well as the finerβphase(Mg17Al12)with homogenous distribution in the matrix can also slightly assist to the enhancement of the mechanical properties of thecomposite.展开更多
To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put fo...To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put forward.The carbonation effect of modified recycled coarse aggregate with three different carbonation methods was evaluated,and water absorption,apparent density and crush index of modified recycled coarse aggregate were measured.Combined with XRD,SEM,and MIP microscopic analysis,the high-efficiency carbonation strengthening mechanism of modified recycled coarse aggregate was revealed.The experimental results show that,compared with the non-carbonated recycled coarse aggregate,the physical and microscopic properties of carbonated recycled coarse aggregate are improved.The method of carbonation with nano-SiO_(2) pre-soaking can realize the high-efficiency carbonation of recycled coarse aggregate,for modified recycled coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 nm.The high-efficiency carbonation strengthening mechanism show that the pre-socked nano-SiO_(2) is bound to the hydration product Ca(OH)_(2) of the old mortar with nano-scale C-S-H,which can improve the CO_(2) absorption rate,accelerate the carbonation reaction,generate more stable CaCO_(3) and nano-scale silica gel,and bond to the dense three-dimensional network structure to realize the bidirectional enhancement of nano-materials and pressurized carbonation.It is concluded that the method of carbonation with nano-SiO_(2) pre-soaking is a novel high-efficiency carbonation modification of recycled coarse aggregate.展开更多
Carbonated recycled powder as cementitious auxiliary material can reduce carbon emissions and realize high-quality recycling of recycled concrete.In this paper,microscopic property of recycled powder with three carbon...Carbonated recycled powder as cementitious auxiliary material can reduce carbon emissions and realize high-quality recycling of recycled concrete.In this paper,microscopic property of recycled powder with three carbonation methods was tested through XRD and SEM,the mechanical property and microstructure of recycled powder mortar with three replacement rates were studied by ISO method and SEM,and the strengthening mechanism was analyzed.The results showed that the mechanical property of recycled powder mortar decreased with the increasing of replacement rate.It is suggested that the replacement rate of recycled powder should not exceed 20%.The strength index and activity index of carbonated recycled powder mortar were improved,in which the flexural strength was increased by 27.85%and compressive strength was increased by 20%at the maximum.Recycled powder can be quickly and completely carbonated,and the improvement effect of CH pre-soaking carbonation was the best.The activity index of carbonated recycled powder can meet the requirements of Grade II technical standard for recycled powder.Microscopic results revealed the activation mechanism of carbonated recycled powder such as surplus calcium source effect,alkaline polycondensation effect and carbonation enhancement effect.展开更多
A green environmental protection and enhanced leaching process was proposed to recover all elements from spent lithium iron phosphate(LiFePO_(4)) lithium batteries.In order to reduce the influence of Al impurity in th...A green environmental protection and enhanced leaching process was proposed to recover all elements from spent lithium iron phosphate(LiFePO_(4)) lithium batteries.In order to reduce the influence of Al impurity in the recovery process,NaOH was used to remove impurity.After impurity removal,the spent LiFePO_(4) cathode material was used as raw material under the H_(2)SO_(4) system,and the pressure oxidation leaching process was adopted to achieve the preferential leaching of lithium.The E-pH diagram of the Fe-P-Al-H_(2)O system can determine the stable region of each element in the recovery process of spent LiFePO_(4)Li-batteries.Under the optimal conditions(500 r·min^(-1),15 h,363.15 K,0.4 MPa,the liquid-solid ratio was 4:1 ml·g^(-1)and the acid-material ratio was 0.29),the leaching rate of Li was 99.24%,Fe,Al,and Ti were 0.10%,2.07%,and 0.03%,respectively.The Fe and P were precipitated and recovered as FePO_(4)·2H_(2)O.The kinetic analysis shows that the process of high-pressure acid leaching of spent LiFePO_(4) materials depends on the surface chemical reaction.Through the life cycle assessment(LCA)of the spent LiFePO_(4) whole recovery process,eight midpoint impact categories were selected to assess the impact of recovery process.The results can provide basic environmental information on production process for recycling industry.展开更多
Background:Combinedhepatocellular carcinoma and cholangiocarcinoma(cHCC-CC)is a rare subtype of primary liver cancers.Its prognostic factors remain unclear.The study aimed to evaluate its long-termoutcome and prognost...Background:Combinedhepatocellular carcinoma and cholangiocarcinoma(cHCC-CC)is a rare subtype of primary liver cancers.Its prognostic factors remain unclear.The study aimed to evaluate its long-termoutcome and prognostic factors by retrospectively reviewing the series of cHCC-CC after curative resection from our institute.Methods:Atotal of 55 pathologically confirmed cHCC-CC patients undergoing curative resections between January 2003 and January 2018 at the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)were included.The clinicopathological and follow-up data were retrieved.Overall survival(OS)and recurrence-free survivals(RFS)were analysed by Kaplan–Meier curve.The independent prognostic factors were determined by using univariate andmultivariate Cox analyses.Results:Therewere 41 males and 14 females,with a median age of 51.0(interquartile range,44.0–60.0)years.The 1-,3-,and 5-year OS and RFS rates in cHCC-CC were 80.0%,25.5%,and 16.4%,respectively,and 52.7%,21.8%,and 10.9%,respectively.The median OS and RFS were 24.9 and 14.5 months,respectively.Univariate and multivariate analyses revealed that elevated alpha-fetal protein(AFP)and/or CA19-9,vascular invasion,local extra-hepatic invasion,and lymph-node metastasis(LNM)were independent unfavorable prognostic factors for OS and RFS(all P<0.005).Furthermore,elevated AFP and/or CA19-9 were independent unfavorable prognostic factors in various subgroups of cHCC-CC,including patients aged<60 years,positive hepatitis B surface antigen,cirrhosis,single tumor,tumor size5 cm,no vascular invasion,no LNM,and no local extra-hepatic invasion(all P<0.05).Conclusions:ElevatedAFP and/or CA19-9,vascular invasion,local extra-hepatic invasion,and LNM were independent unfavorable prognostic factors for long-term survival of cHCC-CC undergoing curative resections.Patients with normal levels of AFP and CA19-9 had better prognosis.展开更多
A novel praseodymium complex [PrCl(H_2O)_3(L)(HL)]_nnCl(1, HL = 3-hydroxy-2-methylquinoline-4-carboxylic acid) has been synthesized through hydrothermal reactions and characterized by single-crystal X-ray diffraction....A novel praseodymium complex [PrCl(H_2O)_3(L)(HL)]_nnCl(1, HL = 3-hydroxy-2-methylquinoline-4-carboxylic acid) has been synthesized through hydrothermal reactions and characterized by single-crystal X-ray diffraction. Complex 1 crystallizes in P2_1 space group of the monoclinic system, with a = 7.3146(2), b = 9.3963(3), c = 17.4872(5) ?, β = 96.818(3)°, V = 1193.40(6) ?~3, C_(22)H_(23)Cl_2N_2O_9Pr, M_r = 671.23, Z = 2, D_c = 1.868 g/cm^3, μ(MoKα) = 2.322 mm^(-1) and F(000) = 668. The praseodymium ion is surrounded by seven oxygen atoms and one chlorine atom to yield a slightly distorted square antiprism. Complex 1 is characterized by a one-dimensional chain-like structure. A two-dimensional supramolecular layer is formed via hydrogen-bonding interactions. Solid-state photoluminescence spectrum reveals that it shows red emission. The emission bands are ascribed to the characteristic emission of the 4 f electron transitions of ~3P_0 → ~3H_J(J = 5 and 6) and ~3P_0 → ~3F_4 of Pr^(3+) ions. Solid-state UV/Vis diffuse reflectance spectroscopy exhibits that it has an optical band gap of 2.75 eV.展开更多
Unidirectional porous AlN ceramics(UP-AlNs)have attracted great attention for their wide applications in catalyst supports,filters and composite reinforcements.However,traditional fabrication processes usually require...Unidirectional porous AlN ceramics(UP-AlNs)have attracted great attention for their wide applications in catalyst supports,filters and composite reinforcements.However,traditional fabrication processes usually require high temperature and long production cycle.Herein,UP-AlNs were successfully fabricated via the combination of tertiary butyl alcohol(TBA)-based freeze casting and combustion synthesis route using Al and AlN powders as raw materials.The microstructure,open porosity,thermal conductivity and compressive strength of UP-AlNs can be manipulated by synergistically regulating the AlN diluent content and Al/AlN solid loading of the freezing slurries.The optimal UP-AlNs exhibited controllable structure wavelength(λ)and open porosity in a wide range of 21.1-47.1μm and 54.2%-86.0%,respectively.In addition,the corresponding products also possessed anisotropic thermal conductivity and compressive strength.This novel route for the fabrication of UP-AlNs has the advantages of low cost,energy-saving and high efficiency,which shows significant promise for industrial applications.展开更多
Spark is a distributed data processing framework based on memory.Memory allocation is a focus question of Spark research.A good memory allocation scheme can effectively improve the efficiency of task execution and mem...Spark is a distributed data processing framework based on memory.Memory allocation is a focus question of Spark research.A good memory allocation scheme can effectively improve the efficiency of task execution and memory resource utilization of the Spark.Aiming at the memory allocation problem in the Spark2.x version,this paper optimizes the memory allocation strategy by analyzing the Spark memory model,the existing cache replacement algorithms and the memory allocation methods,which is on the basis of minimizing the storage area and allocating the execution area according to the demand.It mainly including two parts:cache replacement optimization and memory allocation optimization.Firstly,in the storage area,the cache replacement algorithm is optimized according to the characteristics of RDD Partition,which is combined with PCA dimension.In this section,the four features of RDD Partition are selected.When the RDD cache is replaced,only two most important features are selected by PCA dimension reduction method each time,thereby ensuring the generalization of the cache replacement strategy.Secondly,the memory allocation strategy of the execution area is optimized according to the memory requirement of Task and the memory space of storage area.In this paper,a series of experiments in Spark on Yarn mode are carried out to verify the effectiveness of the optimization algorithm and improve the cluster performance.展开更多
Effective heat dissipation is a crucial issue in electrochemical energy storage devices. Thus, it is highly desirable to develop high-performance electrode materials with high thermal conductivity. Here, we report a f...Effective heat dissipation is a crucial issue in electrochemical energy storage devices. Thus, it is highly desirable to develop high-performance electrode materials with high thermal conductivity. Here, we report a facile one-step electrodeposition method to synthesize ternary cobalt nickel sulfide（CoNi2S4）flower-like nanosheets which are grown on graphite foil（GF） as binder-free electrode materials for supercapacitors. The as-fabricated GF/CoNi2S4 integrated electrode manifested an excellent thermal conductivity of 620.1 W·m-1·K-1 and a high specific capacitance of 881 F·g-2 at 5 mA cm-2, as well as good rate capability and cycling stability. Ultimately, the all-solid-state symmetric supercapacitor based on these advanced electrodes demonstrated superior heat dissipation performance during the galvanostatic charge-discharge processes. This novel strategy provides a new example of effective thermal management for potential applications in energy storage devices.展开更多
In distributed storage systems,file access efficiency has an important impact on the real-time nature of information forensics.As a popular approach to improve file accessing efficiency,prefetching model can fetches d...In distributed storage systems,file access efficiency has an important impact on the real-time nature of information forensics.As a popular approach to improve file accessing efficiency,prefetching model can fetches data before it is needed according to the file access pattern,which can reduce the I/O waiting time and increase the system concurrency.However,prefetching model needs to mine the degree of association between files to ensure the accuracy of prefetching.In the massive small file situation,the sheer volume of files poses a challenge to the efficiency and accuracy of relevance mining.In this paper,we propose a massive files prefetching model based on LSTM neural network with cache transaction strategy to improve file access efficiency.Firstly,we propose a file clustering algorithm based on temporal locality and spatial locality to reduce the computational complexity.Secondly,we propose a definition of cache transaction according to files occurrence in cache instead of time-offset distance based methods to extract file block feature accurately.Lastly,we innovatively propose a file access prediction algorithm based on LSTM neural network which predict the file that have high possibility to be accessed.Experiments show that compared with the traditional LRU and the plain grouping methods,the proposed model notably increase the cache hit rate and effectively reduces the I/O wait time.展开更多
Gd_(2) O_(3) nanoparticles modified g-C_(3) N_(4) photocatalytic composites were synthesized by a simple one-step hydrothermal method.The structure,morphology,optical properties of the prepared photocatalyst were char...Gd_(2) O_(3) nanoparticles modified g-C_(3) N_(4) photocatalytic composites were synthesized by a simple one-step hydrothermal method.The structure,morphology,optical properties of the prepared photocatalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),field emission transmission electron microscopy(FETEM) and X-ray photoelectron spectroscopy(XPS).The result demonstrates that gadolinium is mainly dispersed on the surface of g-C_(3) N_(4) in the form of Gd_(2) O_(3),and does not destroy the lattice structure of g-C_(3) N_(4).Besides,the gadolinium can cause the red shift of the absorption edge of light,narrow the band gap,and increase the separation efficiency of the photogenerated electron and hole of g-C_(3) N_(4).Especially,the specific surface area of g-C_(3) N_(4) can be significantly increased.Furthermore,g-C_(3) N_(4)/Gd-0.05 displays the highest photodegradation performance when it is used for degradation of methyl orange(MO),methylene blue(MB) and Rhodamine B(RhB).The photodegradation rate of g-C_(3) N_(4)/Gd-0.05 composites is 72.4% for MO,95.5% for RhB,100% for MB after120 min under visible light(λ> 420 nm) irradiation.Narrow band gap promotes the separation of photogenerated electron and hole,which enhances the photocatalytic activity of g-C_(3) N_(4).It is noted that g-C_(3) N_(4)/Gd-0.05 exhibits excellent photocatalytic stability by the photocurrent and the cyclic photodegradation of MO.展开更多
Superconvergence and recovery a posteriori error estimates of the finite element ap- proximation for general convex optimal control problems are investigated in this paper. We obtain the superconvergence properties of...Superconvergence and recovery a posteriori error estimates of the finite element ap- proximation for general convex optimal control problems are investigated in this paper. We obtain the superconvergence properties of finite element solutions, and by using the superconvergence results we get recovery a posteriori error estimates which are asymptotically exact under some regularity conditions. Some numerical examples are provided to verify the theoretical results.展开更多
In this paper, a class of SEIQV epidemic model with general nonlinear incidence rate is investigated. By constructing Lyapunov function, it is shown that the disease-free equilibrium is globally asymptotically stable ...In this paper, a class of SEIQV epidemic model with general nonlinear incidence rate is investigated. By constructing Lyapunov function, it is shown that the disease-free equilibrium is globally asymptotically stable if the basic reproduction number R0 ≤ 1. If R0 〉 1, we show that the endemic equilibrium is globally asymptotically stable by applying Li and Muldowney geometric approach.展开更多
In this article, some facts of the value distribution theory for meromorphic func- tions with maximal deficiency sum in the plane will be considered in the punctured plane, and also the relationship between the defici...In this article, some facts of the value distribution theory for meromorphic func- tions with maximal deficiency sum in the plane will be considered in the punctured plane, and also the relationship between the deficiency of meromorphic function in the punctured plane and that of their derivatives is studied.展开更多
With the rapid development of social network,public opinion monitoring based on social networks is becoming more and more important.Many platforms have achieved some success in public opinion monitoring.However,these ...With the rapid development of social network,public opinion monitoring based on social networks is becoming more and more important.Many platforms have achieved some success in public opinion monitoring.However,these platforms cannot perform well in scalability,fault tolerance,and real-time performance.In this paper,we propose a novel social-network-oriented public opinion monitoring platform based on ElasticSearch(SNES).Firstly,SNES integrates the module of distributed crawler cluster,which provides real-time social media data access.Secondly,SNES integrates ElasticSearch which can store and retrieve massive unstructured data in near real time.Finally,we design subscription module based on Apache Kafka to connect the modules of the platform together in the form of message push and consumption,improving message throughput and the ability of dynamic horizontal scaling.A great number of empirical experiments prove that the platform can adapt well to the social network with highly real-time data and has good performance in public opinion monitoring.展开更多
A robust optimization design method is proposed to investigate the influence of the hook position on the vertical vibration(bending)of an automobile exhaust system.A block diagram for the robustness analysis of the ex...A robust optimization design method is proposed to investigate the influence of the hook position on the vertical vibration(bending)of an automobile exhaust system.A block diagram for the robustness analysis of the exhaust system is initially constructed from the major affecting factors.Secondly,the second-order inertia force is set as the vibration excitation source of the exhaust system and the displacement of four hooks of the exhaust system is selected as the variable factor.Then tests are carried out to investigate the resulting vertical bending considering four influencing factors and three levels of analysis.Finally,a variance analysis of the vertical bending is performed.The present study provides a set of guidelines to control the key factors affecting the vibration of vehicle exhaust systems while proposing an effective method to reduce vehicle vibration and improve noise analysis。展开更多
A novel iridium-complex,（BPPBI） 2 Ir（2-TFDBC）[BPPBI=2-（biphenyl-4-yl）-1-phenyl-1H-benzo[d]imidazole,2-TFDBC=1-（9-ethyl-9H-carbazol-2-yl）-4,4,4-trifluorobutane-1,3-dione],was synthesized,and its structure and c...A novel iridium-complex,（BPPBI） 2 Ir（2-TFDBC）[BPPBI=2-（biphenyl-4-yl）-1-phenyl-1H-benzo[d]imidazole,2-TFDBC=1-（9-ethyl-9H-carbazol-2-yl）-4,4,4-trifluorobutane-1,3-dione],was synthesized,and its structure and component were confirmed by 1 H NMR and element analysis,respectively.UV-Vis absorption and photoluminescent（PL） spectra of（BPPBI） 2 Ir（2-TFDBC） in dichloromethane were investigated.The Ir-complex exhibited a long wavelength excitation of 470 nm,i.e.,low-energy excitation.So,it is a promising candidate for phosphorescent probe and PL material.（BPPBI） 2 Ir（2-TFDBC）-based electroluminescent devices,ITO/MoO 3（10 nm）/NPB（80 nm）/CBP：x（BPPBI） 2 Ir（2-TFDBC）（20 nm）/TPBi（45 nm）/LiF/Al,were fabricated,where x（%） was of 4% or 8% doping concentration（mass fraction）;ITO=indium tin oxides;NBP=N,N＇-bis-（1-naphthalenyl）-N,N＇-bis-phenyl-（1,1＇-biphenyl）4,4＇-diamine,CBP=4,4＇-bis（N-carbazolyl）-1,1＇-biphenyl,TPBi=1,3,5-tris（1-phenyl-1H-benzimidazol-2-yl）benzene.The devices showed a red emission of 620 nm.The maximum current efficiency and brightness were 1.7 cd/A and 4063 cd/m 2 for a device of 8%（mass fraction） doping level,respectively.The moderate luminous efficiency was due to the inadequate energy transfer from the host material to the guest material.展开更多
文摘Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected monthly.This phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate cancer.Methods:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in China.This study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three injections.The primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to 85.Non-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen levels.Results:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two groups.The cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).Both results met the criterion for non-inferiority.Secondary endpoints were similar between groups.Both treatments were well-tolerated.LY01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety profile.Trial registration:ClinicalTrials.gov,NCT04563936.
基金supported by the Science and Technology Research Project of Education Department of Jiangxi Province(GJJ202314,GJ212313,GJJ181018,GJJ202306)Innovation team Funding Project of Xinyu University(CT201901)+1 种基金Key Scientific Research Project of Xinyu University(XJZD1901)Science and Technology Department of Jiangxi Province(20202BAB204001,20171BAB201012).
文摘In recent years,flexible photodetectors(FPDs)have received increasing attention due to their applications in electronic eyes,flexible sensing,terminal devices,and wearable devices.In addition,metallic halide perovskite materials are considered as future materials for FPDs due to their compatibility with flexible substrates,low cost,simple synthesis methods,and superior optoelectronic properties.This review provides a comprehensive overview of the relevant cutting-edge research in the field of flexible perovskite photodetectors(FPPDs)from 2020 to 2022.First,the evaluation criteria for FPPDs are discussed and the development of perovskite stability criteria is emphatically described.Afterwards,the synthesis methods and device construction processes of metal halide perovskite materials commonly used by researchers in the past three years are described.These include single crystals and low-dimensional materials.Moreover,we have elaborated on the research of self-powered FPPD and its contributions in wearability,terminals,and portability.Finally,a summary of developments and possibilities in the field of FPPDs from 2020 to 2022 is provided.
基金Project(51464034) supported by the National Natural Science Foundation of ChinaProjects(GJJ151309,GJJ151010) supported by the Education Department of Jiangxi Province,China
文摘AZ91D alloy composites with1.0%CNTs have been fabricated by a method combined ball milling with stirring casting.The composite was investigated using optical microscopy(OM),X-ray diffraction(XRD),Fourier transform infrared spectroscope(FT-IR),scanning electron microscope(SEM),transmission electron microscope(TEM)and room temperature(RT)tensile test.Theresults show that CNTs were homogeneously distributed in the matrix and maintained integrated structure.The yield strength andductility of AZ91D/CNTs composite were improved by47.2%and112.2%,respectively,when compared with the AZ91alloy.Theuniform distribution of CNTs and the strong interfacial bonds between CNT and the matrix are dominated to the simultaneousimprovement of yield strength and ductility of the composite.In addition,the grain refinement as well as the finerβphase(Mg17Al12)with homogenous distribution in the matrix can also slightly assist to the enhancement of the mechanical properties of thecomposite.
基金Funded by Joint Funds of the National Natural Science Foundation of China(No.U1904188)the Jiangxi Provincial Department of Education Science and Technology Project(Nos.GJJ171079,GJJ181023,and GJJ181022)。
文摘To solve the problem of only surface carbonation and realize high-efficiency carbonation of recycled coarse aggregate,the method of carbonated recycled coarse aggregate with nano materials pre-soaking was first put forward.The carbonation effect of modified recycled coarse aggregate with three different carbonation methods was evaluated,and water absorption,apparent density and crush index of modified recycled coarse aggregate were measured.Combined with XRD,SEM,and MIP microscopic analysis,the high-efficiency carbonation strengthening mechanism of modified recycled coarse aggregate was revealed.The experimental results show that,compared with the non-carbonated recycled coarse aggregate,the physical and microscopic properties of carbonated recycled coarse aggregate are improved.The method of carbonation with nano-SiO_(2) pre-soaking can realize the high-efficiency carbonation of recycled coarse aggregate,for modified recycled coarse aggregate with the method,water absorption is reduced by 23.03%,porosity is reduced by 44.06%,and the average pore diameter is 21.82 nm.The high-efficiency carbonation strengthening mechanism show that the pre-socked nano-SiO_(2) is bound to the hydration product Ca(OH)_(2) of the old mortar with nano-scale C-S-H,which can improve the CO_(2) absorption rate,accelerate the carbonation reaction,generate more stable CaCO_(3) and nano-scale silica gel,and bond to the dense three-dimensional network structure to realize the bidirectional enhancement of nano-materials and pressurized carbonation.It is concluded that the method of carbonation with nano-SiO_(2) pre-soaking is a novel high-efficiency carbonation modification of recycled coarse aggregate.
基金Funded by Joint Funds of the National Natural Science Foundation of China(No.U1904188)Jiangxi Provincial Department of Education Science and Technology Project(Nos.GJJ171079,GJJ181023 and GJJ181022)。
文摘Carbonated recycled powder as cementitious auxiliary material can reduce carbon emissions and realize high-quality recycling of recycled concrete.In this paper,microscopic property of recycled powder with three carbonation methods was tested through XRD and SEM,the mechanical property and microstructure of recycled powder mortar with three replacement rates were studied by ISO method and SEM,and the strengthening mechanism was analyzed.The results showed that the mechanical property of recycled powder mortar decreased with the increasing of replacement rate.It is suggested that the replacement rate of recycled powder should not exceed 20%.The strength index and activity index of carbonated recycled powder mortar were improved,in which the flexural strength was increased by 27.85%and compressive strength was increased by 20%at the maximum.Recycled powder can be quickly and completely carbonated,and the improvement effect of CH pre-soaking carbonation was the best.The activity index of carbonated recycled powder can meet the requirements of Grade II technical standard for recycled powder.Microscopic results revealed the activation mechanism of carbonated recycled powder such as surplus calcium source effect,alkaline polycondensation effect and carbonation enhancement effect.
基金supported by the National Natural Science Foundation of China(51834008,52022109,52274307,and 21804319)National Key Research and Development Program of China(2021YFC2901100)+1 种基金Science Foundation of China University of Petroleum,Beijing(2462022QZDX008,2462021QNX2010,2462020YXZZ019 and 2462020YXZZ016)State Key Laboratory of Heavy Oil Processing(HON-KFKT2022-10).
文摘A green environmental protection and enhanced leaching process was proposed to recover all elements from spent lithium iron phosphate(LiFePO_(4)) lithium batteries.In order to reduce the influence of Al impurity in the recovery process,NaOH was used to remove impurity.After impurity removal,the spent LiFePO_(4) cathode material was used as raw material under the H_(2)SO_(4) system,and the pressure oxidation leaching process was adopted to achieve the preferential leaching of lithium.The E-pH diagram of the Fe-P-Al-H_(2)O system can determine the stable region of each element in the recovery process of spent LiFePO_(4)Li-batteries.Under the optimal conditions(500 r·min^(-1),15 h,363.15 K,0.4 MPa,the liquid-solid ratio was 4:1 ml·g^(-1)and the acid-material ratio was 0.29),the leaching rate of Li was 99.24%,Fe,Al,and Ti were 0.10%,2.07%,and 0.03%,respectively.The Fe and P were precipitated and recovered as FePO_(4)·2H_(2)O.The kinetic analysis shows that the process of high-pressure acid leaching of spent LiFePO_(4) materials depends on the surface chemical reaction.Through the life cycle assessment(LCA)of the spent LiFePO_(4) whole recovery process,eight midpoint impact categories were selected to assess the impact of recovery process.The results can provide basic environmental information on production process for recycling industry.
基金supported by the National Natural Science Foundation of China[No.81772522]the China Postdoctoral Science Foundation[No.2018M643327]the China Postdoctoral Science Foundation[No.2018M643325].
文摘Background:Combinedhepatocellular carcinoma and cholangiocarcinoma(cHCC-CC)is a rare subtype of primary liver cancers.Its prognostic factors remain unclear.The study aimed to evaluate its long-termoutcome and prognostic factors by retrospectively reviewing the series of cHCC-CC after curative resection from our institute.Methods:Atotal of 55 pathologically confirmed cHCC-CC patients undergoing curative resections between January 2003 and January 2018 at the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)were included.The clinicopathological and follow-up data were retrieved.Overall survival(OS)and recurrence-free survivals(RFS)were analysed by Kaplan–Meier curve.The independent prognostic factors were determined by using univariate andmultivariate Cox analyses.Results:Therewere 41 males and 14 females,with a median age of 51.0(interquartile range,44.0–60.0)years.The 1-,3-,and 5-year OS and RFS rates in cHCC-CC were 80.0%,25.5%,and 16.4%,respectively,and 52.7%,21.8%,and 10.9%,respectively.The median OS and RFS were 24.9 and 14.5 months,respectively.Univariate and multivariate analyses revealed that elevated alpha-fetal protein(AFP)and/or CA19-9,vascular invasion,local extra-hepatic invasion,and lymph-node metastasis(LNM)were independent unfavorable prognostic factors for OS and RFS(all P<0.005).Furthermore,elevated AFP and/or CA19-9 were independent unfavorable prognostic factors in various subgroups of cHCC-CC,including patients aged<60 years,positive hepatitis B surface antigen,cirrhosis,single tumor,tumor size5 cm,no vascular invasion,no LNM,and no local extra-hepatic invasion(all P<0.05).Conclusions:ElevatedAFP and/or CA19-9,vascular invasion,local extra-hepatic invasion,and LNM were independent unfavorable prognostic factors for long-term survival of cHCC-CC undergoing curative resections.Patients with normal levels of AFP and CA19-9 had better prognosis.
基金financially supported by the National Natural Science Foundation of China(21975111,21774053,and 51903123)Advanced Analysis and Testing Center of Nanjing Forestry University。
基金supported by the NNSFC(51363009,21764007)Jiangxi Provincial Department of Education’s Item of Science and Technology(GJJ160745 and GJJ151217)
文摘A novel praseodymium complex [PrCl(H_2O)_3(L)(HL)]_nnCl(1, HL = 3-hydroxy-2-methylquinoline-4-carboxylic acid) has been synthesized through hydrothermal reactions and characterized by single-crystal X-ray diffraction. Complex 1 crystallizes in P2_1 space group of the monoclinic system, with a = 7.3146(2), b = 9.3963(3), c = 17.4872(5) ?, β = 96.818(3)°, V = 1193.40(6) ?~3, C_(22)H_(23)Cl_2N_2O_9Pr, M_r = 671.23, Z = 2, D_c = 1.868 g/cm^3, μ(MoKα) = 2.322 mm^(-1) and F(000) = 668. The praseodymium ion is surrounded by seven oxygen atoms and one chlorine atom to yield a slightly distorted square antiprism. Complex 1 is characterized by a one-dimensional chain-like structure. A two-dimensional supramolecular layer is formed via hydrogen-bonding interactions. Solid-state photoluminescence spectrum reveals that it shows red emission. The emission bands are ascribed to the characteristic emission of the 4 f electron transitions of ~3P_0 → ~3H_J(J = 5 and 6) and ~3P_0 → ~3F_4 of Pr^(3+) ions. Solid-state UV/Vis diffuse reflectance spectroscopy exhibits that it has an optical band gap of 2.75 eV.
基金supported by the National Natural Science Foundation of China(No.51872222)the Shaanxi Innovation Capacity Support Program(2018TD-031)the Xi’an Municipal Science and Technology Project(2020KJRC0056)。
文摘Unidirectional porous AlN ceramics(UP-AlNs)have attracted great attention for their wide applications in catalyst supports,filters and composite reinforcements.However,traditional fabrication processes usually require high temperature and long production cycle.Herein,UP-AlNs were successfully fabricated via the combination of tertiary butyl alcohol(TBA)-based freeze casting and combustion synthesis route using Al and AlN powders as raw materials.The microstructure,open porosity,thermal conductivity and compressive strength of UP-AlNs can be manipulated by synergistically regulating the AlN diluent content and Al/AlN solid loading of the freezing slurries.The optimal UP-AlNs exhibited controllable structure wavelength(λ)and open porosity in a wide range of 21.1-47.1μm and 54.2%-86.0%,respectively.In addition,the corresponding products also possessed anisotropic thermal conductivity and compressive strength.This novel route for the fabrication of UP-AlNs has the advantages of low cost,energy-saving and high efficiency,which shows significant promise for industrial applications.
文摘Spark is a distributed data processing framework based on memory.Memory allocation is a focus question of Spark research.A good memory allocation scheme can effectively improve the efficiency of task execution and memory resource utilization of the Spark.Aiming at the memory allocation problem in the Spark2.x version,this paper optimizes the memory allocation strategy by analyzing the Spark memory model,the existing cache replacement algorithms and the memory allocation methods,which is on the basis of minimizing the storage area and allocating the execution area according to the demand.It mainly including two parts:cache replacement optimization and memory allocation optimization.Firstly,in the storage area,the cache replacement algorithm is optimized according to the characteristics of RDD Partition,which is combined with PCA dimension.In this section,the four features of RDD Partition are selected.When the RDD cache is replaced,only two most important features are selected by PCA dimension reduction method each time,thereby ensuring the generalization of the cache replacement strategy.Secondly,the memory allocation strategy of the execution area is optimized according to the memory requirement of Task and the memory space of storage area.In this paper,a series of experiments in Spark on Yarn mode are carried out to verify the effectiveness of the optimization algorithm and improve the cluster performance.
基金financially supported by the National Natural Science Foundation of China (21203236)Shenzhen Peacock Plan (KQCX2015033117354154)+1 种基金Shenzhen basic research plan (JCYJ2015052114432090)the Science & Technology Project of Educational Commission of Jiangxi Province, China (GJJ161198)
文摘Effective heat dissipation is a crucial issue in electrochemical energy storage devices. Thus, it is highly desirable to develop high-performance electrode materials with high thermal conductivity. Here, we report a facile one-step electrodeposition method to synthesize ternary cobalt nickel sulfide（CoNi2S4）flower-like nanosheets which are grown on graphite foil（GF） as binder-free electrode materials for supercapacitors. The as-fabricated GF/CoNi2S4 integrated electrode manifested an excellent thermal conductivity of 620.1 W·m-1·K-1 and a high specific capacitance of 881 F·g-2 at 5 mA cm-2, as well as good rate capability and cycling stability. Ultimately, the all-solid-state symmetric supercapacitor based on these advanced electrodes demonstrated superior heat dissipation performance during the galvanostatic charge-discharge processes. This novel strategy provides a new example of effective thermal management for potential applications in energy storage devices.
基金This work is supported by‘The Fundamental Research Funds for the Central Universities(Grant No.HIT.NSRIF.201714)’‘Weihai Science and Technology Development Program(2016DXGJMS15)’‘Key Research and Development Program in Shandong Provincial(2017GGX90103)’.
文摘In distributed storage systems,file access efficiency has an important impact on the real-time nature of information forensics.As a popular approach to improve file accessing efficiency,prefetching model can fetches data before it is needed according to the file access pattern,which can reduce the I/O waiting time and increase the system concurrency.However,prefetching model needs to mine the degree of association between files to ensure the accuracy of prefetching.In the massive small file situation,the sheer volume of files poses a challenge to the efficiency and accuracy of relevance mining.In this paper,we propose a massive files prefetching model based on LSTM neural network with cache transaction strategy to improve file access efficiency.Firstly,we propose a file clustering algorithm based on temporal locality and spatial locality to reduce the computational complexity.Secondly,we propose a definition of cache transaction according to files occurrence in cache instead of time-offset distance based methods to extract file block feature accurately.Lastly,we innovatively propose a file access prediction algorithm based on LSTM neural network which predict the file that have high possibility to be accessed.Experiments show that compared with the traditional LRU and the plain grouping methods,the proposed model notably increase the cache hit rate and effectively reduces the I/O wait time.
基金Project supported by the National Natural Science Foundation of China (51664047,21667019,22066017)the First Training-class High-end Talents Projects of Science and Technology Innovation in Jiangxi Province (CK202002473)+4 种基金the Key of Natural Science Foundation of Jiangxi Province (20171ACB20016)the Jiangxi Province Major Academic and Technical Leaders Cultivating Object Program (20172BCB22014)the Science and Technology Department of Jiangxi Province(20181BCB18003,20181ACG70025)the Key of Science and Technology Research of the Jiangxi Provincial Department of Education (GJJ191044,GJJ191058)Fujian Key Laboratory of Measurement and Control System for Of-Shore Environment (S1-KF1703)。
文摘Gd_(2) O_(3) nanoparticles modified g-C_(3) N_(4) photocatalytic composites were synthesized by a simple one-step hydrothermal method.The structure,morphology,optical properties of the prepared photocatalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),field emission transmission electron microscopy(FETEM) and X-ray photoelectron spectroscopy(XPS).The result demonstrates that gadolinium is mainly dispersed on the surface of g-C_(3) N_(4) in the form of Gd_(2) O_(3),and does not destroy the lattice structure of g-C_(3) N_(4).Besides,the gadolinium can cause the red shift of the absorption edge of light,narrow the band gap,and increase the separation efficiency of the photogenerated electron and hole of g-C_(3) N_(4).Especially,the specific surface area of g-C_(3) N_(4) can be significantly increased.Furthermore,g-C_(3) N_(4)/Gd-0.05 displays the highest photodegradation performance when it is used for degradation of methyl orange(MO),methylene blue(MB) and Rhodamine B(RhB).The photodegradation rate of g-C_(3) N_(4)/Gd-0.05 composites is 72.4% for MO,95.5% for RhB,100% for MB after120 min under visible light(λ> 420 nm) irradiation.Narrow band gap promotes the separation of photogenerated electron and hole,which enhances the photocatalytic activity of g-C_(3) N_(4).It is noted that g-C_(3) N_(4)/Gd-0.05 exhibits excellent photocatalytic stability by the photocurrent and the cyclic photodegradation of MO.
基金supported by Guangdong Provincial"Zhujiang Scholar Award Project"National Science Foundation of China 10671163+2 种基金the National Basic Research Program under the Grant 2005CB321703Scientific Research Fund of Hunan Provincial Education Department 06A069Guangxi Natural Science Foundation 0575029
文摘Superconvergence and recovery a posteriori error estimates of the finite element ap- proximation for general convex optimal control problems are investigated in this paper. We obtain the superconvergence properties of finite element solutions, and by using the superconvergence results we get recovery a posteriori error estimates which are asymptotically exact under some regularity conditions. Some numerical examples are provided to verify the theoretical results.
基金The first author was supported by Zhejiang Provincial Natural Science Foundation of China under Grant No. LQ14A010004.
文摘In this paper, a class of SEIQV epidemic model with general nonlinear incidence rate is investigated. By constructing Lyapunov function, it is shown that the disease-free equilibrium is globally asymptotically stable if the basic reproduction number R0 ≤ 1. If R0 〉 1, we show that the endemic equilibrium is globally asymptotically stable by applying Li and Muldowney geometric approach.
基金supported by the National Natural Science Foundation of China(11201395)supported by the Science Foundation of Educational Commission of Hubei Province(D20132804)supported by the Science Foundation of Jiangxi Province(20122BAB201006)
文摘In this article, some facts of the value distribution theory for meromorphic func- tions with maximal deficiency sum in the plane will be considered in the punctured plane, and also the relationship between the deficiency of meromorphic function in the punctured plane and that of their derivatives is studied.
基金This work is supported by State Grid Science and Technology Project under Grant Nos.520613180002,62061318C002the Fundamental Research Funds for the Central Universities(Grant Nos.HIT.NSRIF.201714)+4 种基金Weihai Science and Technology Development Program(2016DXGJMS15)Key Research and Development Program in Shandong Provincial(2017GGX90103)Fujian Young and Middle-aged Teacher Education Research Project,Grant No.JAT160466Jiangsu Polytechnic College of Agriculture and Forestry Key R&D Projects(2018kj11)Study and Development of Smart Agriculture Control System Based on Spark Big Data Decision(2017N0029).
文摘With the rapid development of social network,public opinion monitoring based on social networks is becoming more and more important.Many platforms have achieved some success in public opinion monitoring.However,these platforms cannot perform well in scalability,fault tolerance,and real-time performance.In this paper,we propose a novel social-network-oriented public opinion monitoring platform based on ElasticSearch(SNES).Firstly,SNES integrates the module of distributed crawler cluster,which provides real-time social media data access.Secondly,SNES integrates ElasticSearch which can store and retrieve massive unstructured data in near real time.Finally,we design subscription module based on Apache Kafka to connect the modules of the platform together in the form of message push and consumption,improving message throughput and the ability of dynamic horizontal scaling.A great number of empirical experiments prove that the platform can adapt well to the social network with highly real-time data and has good performance in public opinion monitoring.
基金science and technology projects of Jiangxi Provincial Education Department(GJJ161186).
文摘A robust optimization design method is proposed to investigate the influence of the hook position on the vertical vibration(bending)of an automobile exhaust system.A block diagram for the robustness analysis of the exhaust system is initially constructed from the major affecting factors.Secondly,the second-order inertia force is set as the vibration excitation source of the exhaust system and the displacement of four hooks of the exhaust system is selected as the variable factor.Then tests are carried out to investigate the resulting vertical bending considering four influencing factors and three levels of analysis.Finally,a variance analysis of the vertical bending is performed.The present study provides a set of guidelines to control the key factors affecting the vibration of vehicle exhaust systems while proposing an effective method to reduce vehicle vibration and improve noise analysis。
基金Supported by the Natural Science Foundation of Guangdong Province,China(No.10152404801000017)
文摘A novel iridium-complex,（BPPBI） 2 Ir（2-TFDBC）[BPPBI=2-（biphenyl-4-yl）-1-phenyl-1H-benzo[d]imidazole,2-TFDBC=1-（9-ethyl-9H-carbazol-2-yl）-4,4,4-trifluorobutane-1,3-dione],was synthesized,and its structure and component were confirmed by 1 H NMR and element analysis,respectively.UV-Vis absorption and photoluminescent（PL） spectra of（BPPBI） 2 Ir（2-TFDBC） in dichloromethane were investigated.The Ir-complex exhibited a long wavelength excitation of 470 nm,i.e.,low-energy excitation.So,it is a promising candidate for phosphorescent probe and PL material.（BPPBI） 2 Ir（2-TFDBC）-based electroluminescent devices,ITO/MoO 3（10 nm）/NPB（80 nm）/CBP：x（BPPBI） 2 Ir（2-TFDBC）（20 nm）/TPBi（45 nm）/LiF/Al,were fabricated,where x（%） was of 4% or 8% doping concentration（mass fraction）;ITO=indium tin oxides;NBP=N,N＇-bis-（1-naphthalenyl）-N,N＇-bis-phenyl-（1,1＇-biphenyl）4,4＇-diamine,CBP=4,4＇-bis（N-carbazolyl）-1,1＇-biphenyl,TPBi=1,3,5-tris（1-phenyl-1H-benzimidazol-2-yl）benzene.The devices showed a red emission of 620 nm.The maximum current efficiency and brightness were 1.7 cd/A and 4063 cd/m 2 for a device of 8%（mass fraction） doping level,respectively.The moderate luminous efficiency was due to the inadequate energy transfer from the host material to the guest material.
