Type 2 diabetes （T2D） is now considered a pandemic noncommunicable disease, and the prevalence is still increasing steadily worldwide. Several lines of evidence, including T2D, is an aging-related disease, and the p...Type 2 diabetes （T2D） is now considered a pandemic noncommunicable disease, and the prevalence is still increasing steadily worldwide. Several lines of evidence, including T2D, is an aging-related disease, and the phenomenon of the metabolic memory and developmental origins of adult diabetes argues that epigenetic disorder plays critical roles in the development of T2D. Environmental factors can affect epigenetics during early fetal life until adulthood. Altered epigenetics can be maintained during mitosis and meiosis, so that the subsequent response to environ- mental cue in later life has also been altered. Epigenetic aberra- tions affect miRNA expression and functions, and altered miRNA expression can also affect expression of many genes including those relevant to epigenetics. Thus, the development of T2D is an accumulative process that may involve complex interactions be- tween altered transcription factors, miRNA functions, and in- creased epigenetics disorder in response to environmental stimuli during different stages of life.展开更多
The relation between domain wall motion and intensity of driven current is examined in a phenomenological theory where the kinetic energy is expanded as a series of polynomial function of current density just as the L...The relation between domain wall motion and intensity of driven current is examined in a phenomenological theory where the kinetic energy is expanded as a series of polynomial function of current density just as the Landau phase transition theory. The dependency of velocity on current density is square root which degenerates into linear if the current is much higher than the critical value. The theory result is consistent with several previous experiments and also can explain the change of critical current in the presence of temperature. The role of temperature playing in the dynamics of domain wall motion is also discussed. The phase transition theory in terms of current density is employed to explain the critical behavior of domain wall motion.展开更多
文摘Type 2 diabetes （T2D） is now considered a pandemic noncommunicable disease, and the prevalence is still increasing steadily worldwide. Several lines of evidence, including T2D, is an aging-related disease, and the phenomenon of the metabolic memory and developmental origins of adult diabetes argues that epigenetic disorder plays critical roles in the development of T2D. Environmental factors can affect epigenetics during early fetal life until adulthood. Altered epigenetics can be maintained during mitosis and meiosis, so that the subsequent response to environ- mental cue in later life has also been altered. Epigenetic aberra- tions affect miRNA expression and functions, and altered miRNA expression can also affect expression of many genes including those relevant to epigenetics. Thus, the development of T2D is an accumulative process that may involve complex interactions be- tween altered transcription factors, miRNA functions, and in- creased epigenetics disorder in response to environmental stimuli during different stages of life.
文摘The relation between domain wall motion and intensity of driven current is examined in a phenomenological theory where the kinetic energy is expanded as a series of polynomial function of current density just as the Landau phase transition theory. The dependency of velocity on current density is square root which degenerates into linear if the current is much higher than the critical value. The theory result is consistent with several previous experiments and also can explain the change of critical current in the presence of temperature. The role of temperature playing in the dynamics of domain wall motion is also discussed. The phase transition theory in terms of current density is employed to explain the critical behavior of domain wall motion.
