The liver is the most common site of metastases in patients with colorectal cancer.Colorectal liver metastases(CRLMs)are the result of molecular mechanisms that involve different cells of the liver microenvironment.Th...The liver is the most common site of metastases in patients with colorectal cancer.Colorectal liver metastases(CRLMs)are the result of molecular mechanisms that involve different cells of the liver microenvironment.The aberrant activation of Wingless/It(Wnt)/β-catenin signals downstream of Wnt ligands initially drives the oncogenic transformation of the colon epithelium,but also the progression of metastatization through the epithelial-mesenchymal transition/mesenchymalepithelial transition interactions.In liver microenvironment,metastatic cells can also survive and adapt through dormancy,which makes them less susceptible to pro-apoptotic signals and therapies.Treatment of CRLMs is challenging due to its variability and heterogeneity.Advances in surgery and oncology have been made in the last decade and a pivotal role for Wnt/β-catenin pathway has been recognized in chemoresistance.At the state of art,there is a lack of clear understanding of why and how this occurs and thus where exactly the opportunities for developing anti-CRLMs therapies may lie.In this review,current knowledge on the involvement of Wnt signaling in the development of CRLMs was considered.In addition,an overview of useful biomarkers with a revision of surgical and non-surgical therapies currently accepted in the clinical practice for colorectal liver metastasis patients were provided.展开更多
Synthesized iron oxyhydroxide was applied for the adsorptive removal of As(V)and As(III)from the aquas media.Additionally,this investigation highlighted the synergistic effect of calcium carbonate in conjunction with ...Synthesized iron oxyhydroxide was applied for the adsorptive removal of As(V)and As(III)from the aquas media.Additionally,this investigation highlighted the synergistic effect of calcium carbonate in conjunction with iron oxyhydroxide,resulting in enhanced removal efficiency.The experiment was conducted under various conditions:concentration,dosage,pH,agitation,and temperature.Material characterizations such as Brunauer Emmett Teller,X-ray diffraction,scanning electron microscopy,and Fourier transform infrared spectroscopy were implied to understand adsorption mechanisms.The Langmuir model revealed optimal concentrations for As(V)=500μg/L at pH-5 and As(III)=200μg/L at pH-7,resulting in 95%and 93%adsorption efficiencies,respectively.Maximum adsorption capacities“qm”were found to be 1266.943μg/g for As(V)and 1080.241μg/g for As(III).Freundlich model demonstrated favorable adsorption by indicating“n>1”such as As(V)=2.542 and As(III)=2.707;similarly,the speciation factor“RL<1”for both species as As(V)=0.1 and As(III)=0.5,respectively.The kinetic study presented a pseudo-second-order model as best fitted,indicating throughout chemisorption processes for removing As(V)and As(III).Furthermore,incorporating calcium carbonate presented a significant leap in the removal efficiency,indicating As(V)from 95%to 98%and As(III)from 93%to 96%,respectively.Our findings offer profound motivation for developing effective and sustainable solutions to tackle arsenic contamination,underscoring the exceptional promise of iron oxyhydroxide in conjunction with calcium carbonate to achieve maximum removal efficiency.展开更多
AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means ...AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological assessments.METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye drops.CONCLUSION: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.展开更多
In this study an artisanal“Porter style”beer has been enriched with diverse natural bioactive substances,following all-grain brewing method.Common beer generally contains a poor content of phenolic acids which confe...In this study an artisanal“Porter style”beer has been enriched with diverse natural bioactive substances,following all-grain brewing method.Common beer generally contains a poor content of phenolic acids which confers a low antioxidant power and nutritional value,also due to the presence of ethanol.However in this work we aimed to enrich beer with different flavonoids and other food supplements like taurine,resveratrol and caffeine,thus enhancing its nutritional value and energizing properties.A series of flavonoid/phenol-enriched artisanal beers have been prepared,then sample of each has been tested in vitro to evaluate antioxidant activity,chelating power and enzymatic inhibition capacity.Beer samples were also analysed with HPLC-DAD system to determinate flavonoid and phenol contents.Results show increased nutritional values and significant antioxidant properties in comparison with not-fortified beer as control.展开更多
Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The clinical presentation of this pathology includes fever,dry cough,fatigue ...Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The clinical presentation of this pathology includes fever,dry cough,fatigue and acute respiratory distress syndrome that can lead to death infected patients.Current studies on coronavirus disease 2019(COVID-19)continue to highlight the urgent need for an effective therapy.Numerous therapeutic strategies have been used until now but,to date,there is no specific effective treatment for SARS-CoV-2 infection.Elevated inflammatory cytokines have been reported in patients with COVID-19.Evidence suggests that elevated cytokine levels,reflecting a hyperinflammatory response secondary to SARS-CoV-2 infection,are responsible for multi-organ damage in patients with COVID-19.For these reason,numerous randomized clinical trials are currently underway to explore the effectiveness of biopharmaceutical drugs,such as,interleukin-1 blockers,interleukin-6 inhibitors,Janus kinase inhibitors,in COVID-19.The aim of the present paper is to briefly summarize the pathogenetic rationale and the state of the art of therapeutic strategy blocking hyperinflammation.展开更多
文摘The liver is the most common site of metastases in patients with colorectal cancer.Colorectal liver metastases(CRLMs)are the result of molecular mechanisms that involve different cells of the liver microenvironment.The aberrant activation of Wingless/It(Wnt)/β-catenin signals downstream of Wnt ligands initially drives the oncogenic transformation of the colon epithelium,but also the progression of metastatization through the epithelial-mesenchymal transition/mesenchymalepithelial transition interactions.In liver microenvironment,metastatic cells can also survive and adapt through dormancy,which makes them less susceptible to pro-apoptotic signals and therapies.Treatment of CRLMs is challenging due to its variability and heterogeneity.Advances in surgery and oncology have been made in the last decade and a pivotal role for Wnt/β-catenin pathway has been recognized in chemoresistance.At the state of art,there is a lack of clear understanding of why and how this occurs and thus where exactly the opportunities for developing anti-CRLMs therapies may lie.In this review,current knowledge on the involvement of Wnt signaling in the development of CRLMs was considered.In addition,an overview of useful biomarkers with a revision of surgical and non-surgical therapies currently accepted in the clinical practice for colorectal liver metastasis patients were provided.
基金funded by the National Natural Science Foundation of China(Nos.42177078 and 42020104005).
文摘Synthesized iron oxyhydroxide was applied for the adsorptive removal of As(V)and As(III)from the aquas media.Additionally,this investigation highlighted the synergistic effect of calcium carbonate in conjunction with iron oxyhydroxide,resulting in enhanced removal efficiency.The experiment was conducted under various conditions:concentration,dosage,pH,agitation,and temperature.Material characterizations such as Brunauer Emmett Teller,X-ray diffraction,scanning electron microscopy,and Fourier transform infrared spectroscopy were implied to understand adsorption mechanisms.The Langmuir model revealed optimal concentrations for As(V)=500μg/L at pH-5 and As(III)=200μg/L at pH-7,resulting in 95%and 93%adsorption efficiencies,respectively.Maximum adsorption capacities“qm”were found to be 1266.943μg/g for As(V)and 1080.241μg/g for As(III).Freundlich model demonstrated favorable adsorption by indicating“n>1”such as As(V)=2.542 and As(III)=2.707;similarly,the speciation factor“RL<1”for both species as As(V)=0.1 and As(III)=0.5,respectively.The kinetic study presented a pseudo-second-order model as best fitted,indicating throughout chemisorption processes for removing As(V)and As(III).Furthermore,incorporating calcium carbonate presented a significant leap in the removal efficiency,indicating As(V)from 95%to 98%and As(III)from 93%to 96%,respectively.Our findings offer profound motivation for developing effective and sustainable solutions to tackle arsenic contamination,underscoring the exceptional promise of iron oxyhydroxide in conjunction with calcium carbonate to achieve maximum removal efficiency.
文摘AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological assessments.METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye drops.CONCLUSION: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.
文摘In this study an artisanal“Porter style”beer has been enriched with diverse natural bioactive substances,following all-grain brewing method.Common beer generally contains a poor content of phenolic acids which confers a low antioxidant power and nutritional value,also due to the presence of ethanol.However in this work we aimed to enrich beer with different flavonoids and other food supplements like taurine,resveratrol and caffeine,thus enhancing its nutritional value and energizing properties.A series of flavonoid/phenol-enriched artisanal beers have been prepared,then sample of each has been tested in vitro to evaluate antioxidant activity,chelating power and enzymatic inhibition capacity.Beer samples were also analysed with HPLC-DAD system to determinate flavonoid and phenol contents.Results show increased nutritional values and significant antioxidant properties in comparison with not-fortified beer as control.
文摘Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The clinical presentation of this pathology includes fever,dry cough,fatigue and acute respiratory distress syndrome that can lead to death infected patients.Current studies on coronavirus disease 2019(COVID-19)continue to highlight the urgent need for an effective therapy.Numerous therapeutic strategies have been used until now but,to date,there is no specific effective treatment for SARS-CoV-2 infection.Elevated inflammatory cytokines have been reported in patients with COVID-19.Evidence suggests that elevated cytokine levels,reflecting a hyperinflammatory response secondary to SARS-CoV-2 infection,are responsible for multi-organ damage in patients with COVID-19.For these reason,numerous randomized clinical trials are currently underway to explore the effectiveness of biopharmaceutical drugs,such as,interleukin-1 blockers,interleukin-6 inhibitors,Janus kinase inhibitors,in COVID-19.The aim of the present paper is to briefly summarize the pathogenetic rationale and the state of the art of therapeutic strategy blocking hyperinflammation.
