The precision of strip flatness depends on several factors; wear of rolls is one of the main variables that have influence on the surface quality of the strip. The wear of the roils represents a complex friction condi...The precision of strip flatness depends on several factors; wear of rolls is one of the main variables that have influence on the surface quality of the strip. The wear of the roils represents a complex friction condition, sometimes the wear in the backup roll is not analyzed because the strip is not in contact with the backup roll; however, after several campaigns of rolling, the wear in the backup roll becomes dangerous because the pressure distribution is not uniform. Investigation of mechanism of the surface deterioration of the backup roll for the hot strip rolling is very important for the development of the automatic strip shape control system used in hot strip mills. A mathematical model is developed considering the Hertzian pressure distribution between two cylinders with parallel axes. It is used in real time for calculating the wear in the backup roll and in this manner take deci- sions for preventing finished product reworking or damage of equipments, which result in accidents caused by excessive wear in the backup rolls.展开更多
AIM： To investigate the presence of human papillomavirus （HPV） in esophageal squamous papilloma （ESP） and determine p16, p53 and Ki67 expression in a Mexican cohort. METHODS： Nineteen cases diagnosed as ESP,...AIM： To investigate the presence of human papillomavirus （HPV） in esophageal squamous papilloma （ESP） and determine p16, p53 and Ki67 expression in a Mexican cohort. METHODS： Nineteen cases diagnosed as ESP, corresponding to 18 patients were reviewed; nineteen cases of normal esophageal mucosa were used as negative controls. HPV detection was performed by ,amplified chromogenic in situ hybridization （ACISH） using a wide spectrum-cocktail probe and PCR. RESULTS： The average age at presentation was 46.3 years （range 28-72 years）. Patients included four （22.22%） males and 14 （77.77%） females. The most frequent location was upper third （11 cases）, followed by middle third （3 cases） and unknown site （5 cases）. Immunohistochemistry （IHC） revealed basal and focal p53 expression in 17 cases （89%）; p16 was expressed in eight cases （42.10%） and the Ki67 index ranged from 10% to 30%. HPV was detected in 14 out of 16 cases （87.5%） by ACISH： Twelve showed diffuse nuclear patterns and two showed granular patterns. HPV DNA was identified by PCR in 12 out of 14 cases （85.7%）. Low-risk HPV types were detected in the most of the cases. CONCLUSION： This study provides identification of HPV infection in almost 80% of ESP using either ACISH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACISH as an alternative diagnostic tool for HPV detection in ESR .展开更多
文摘The precision of strip flatness depends on several factors; wear of rolls is one of the main variables that have influence on the surface quality of the strip. The wear of the roils represents a complex friction condition, sometimes the wear in the backup roll is not analyzed because the strip is not in contact with the backup roll; however, after several campaigns of rolling, the wear in the backup roll becomes dangerous because the pressure distribution is not uniform. Investigation of mechanism of the surface deterioration of the backup roll for the hot strip rolling is very important for the development of the automatic strip shape control system used in hot strip mills. A mathematical model is developed considering the Hertzian pressure distribution between two cylinders with parallel axes. It is used in real time for calculating the wear in the backup roll and in this manner take deci- sions for preventing finished product reworking or damage of equipments, which result in accidents caused by excessive wear in the backup rolls.
文摘AIM： To investigate the presence of human papillomavirus （HPV） in esophageal squamous papilloma （ESP） and determine p16, p53 and Ki67 expression in a Mexican cohort. METHODS： Nineteen cases diagnosed as ESP, corresponding to 18 patients were reviewed; nineteen cases of normal esophageal mucosa were used as negative controls. HPV detection was performed by ,amplified chromogenic in situ hybridization （ACISH） using a wide spectrum-cocktail probe and PCR. RESULTS： The average age at presentation was 46.3 years （range 28-72 years）. Patients included four （22.22%） males and 14 （77.77%） females. The most frequent location was upper third （11 cases）, followed by middle third （3 cases） and unknown site （5 cases）. Immunohistochemistry （IHC） revealed basal and focal p53 expression in 17 cases （89%）; p16 was expressed in eight cases （42.10%） and the Ki67 index ranged from 10% to 30%. HPV was detected in 14 out of 16 cases （87.5%） by ACISH： Twelve showed diffuse nuclear patterns and two showed granular patterns. HPV DNA was identified by PCR in 12 out of 14 cases （85.7%）. Low-risk HPV types were detected in the most of the cases. CONCLUSION： This study provides identification of HPV infection in almost 80% of ESP using either ACISH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACISH as an alternative diagnostic tool for HPV detection in ESR .
