The main goal of the present paper is to assess the available information so as to obtain a general procedure for dealing with the critical enhancement of the thermodynamic and transport properties of supercritical CO...The main goal of the present paper is to assess the available information so as to obtain a general procedure for dealing with the critical enhancement of the thermodynamic and transport properties of supercritical CO_2 and CO_2 containing binary mixtures for practical and scientific applications. The present review provides comprehensive analysis of the thermodynamic and transport properties of supercritical carbon dioxide and CO_2 containing binary mixtures(experiment and theory) and their various technological and scientific applications in different natural and industrial processes. The available information for the thermodynamic and transport properties(experiment and theory) enhancement(anomaly) of supercritical carbon dioxide and SC CO_2 + solute mixtures is comprehensively reviewed. The effect of long-range order parameter fluctuations on the thermodynamic and transport properties of supercritical fluids(SC CO_2) will be discussed. Simplified scaling type equation based on mode-coupling theory of critical dynamics with two critical amplitudes and one cutoff wave number as fluid-specific parameters was used to accurately predict of the transport properties of supercritical carbon dioxide. The recommended values of the specific parameters(asymptotic critical amplitudes) of the carbon dioxide for practical(prediction of the thermodynamic and transport properties of the supercritical CO_2 for technological applications) and scientific use were provided. The role of the critical line shapes of the carbon dioxide containing binary mixture(SC CO_2+solvent) in determination of the critical behavior of the mixture near the critical point of pure supercritical solvent(CO_2) is discussed. Krichevskii parameter concept for a description of thermodynamic behavior of dilute near-critical SC CO_2+solute mixtures is also discussed. The structural and thermodynamic properties of the carbon dioxide containing binary mixtures near the critical point of pure solvent(CO_2) are discussed.展开更多
A rapid and sensitive liquid chromatography-tandem mass spectrometric （LC-MS/MS） assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma....A rapid and sensitive liquid chromatography-tandem mass spectrometric （LC-MS/MS） assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma. Carbamazepine was used as an internal standard. Analytes and the internal standard were extracted from human plasma by solid-phase extraction technique using Waters Oasis HLB 1 cm3 （30 mg） extraction cartridge. The reconstituted samples were chromatographed on a Hypurity advance C18 column （50mm × 4.6mm, 5 gm） using a mixture of acetonitrile -5 mM ammonium acetate buffer （pH-4.0） （50：50, v/v） as the mobile phase at a flow rate of 0.8mL/min. The calibration curve obtained was linear （r_〉0.99） over the concentration range of 2.01-400.06 ng/mL for telmisartan and 0.05 -10.01 ng/mL for amlodipine. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.5 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies.展开更多
基金supported by Russian Foundation of Basic Research (RFBR) grants № 19-08-00056 and №18-08-00500
文摘The main goal of the present paper is to assess the available information so as to obtain a general procedure for dealing with the critical enhancement of the thermodynamic and transport properties of supercritical CO_2 and CO_2 containing binary mixtures for practical and scientific applications. The present review provides comprehensive analysis of the thermodynamic and transport properties of supercritical carbon dioxide and CO_2 containing binary mixtures(experiment and theory) and their various technological and scientific applications in different natural and industrial processes. The available information for the thermodynamic and transport properties(experiment and theory) enhancement(anomaly) of supercritical carbon dioxide and SC CO_2 + solute mixtures is comprehensively reviewed. The effect of long-range order parameter fluctuations on the thermodynamic and transport properties of supercritical fluids(SC CO_2) will be discussed. Simplified scaling type equation based on mode-coupling theory of critical dynamics with two critical amplitudes and one cutoff wave number as fluid-specific parameters was used to accurately predict of the transport properties of supercritical carbon dioxide. The recommended values of the specific parameters(asymptotic critical amplitudes) of the carbon dioxide for practical(prediction of the thermodynamic and transport properties of the supercritical CO_2 for technological applications) and scientific use were provided. The role of the critical line shapes of the carbon dioxide containing binary mixture(SC CO_2+solvent) in determination of the critical behavior of the mixture near the critical point of pure supercritical solvent(CO_2) is discussed. Krichevskii parameter concept for a description of thermodynamic behavior of dilute near-critical SC CO_2+solute mixtures is also discussed. The structural and thermodynamic properties of the carbon dioxide containing binary mixtures near the critical point of pure solvent(CO_2) are discussed.
文摘A rapid and sensitive liquid chromatography-tandem mass spectrometric （LC-MS/MS） assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma. Carbamazepine was used as an internal standard. Analytes and the internal standard were extracted from human plasma by solid-phase extraction technique using Waters Oasis HLB 1 cm3 （30 mg） extraction cartridge. The reconstituted samples were chromatographed on a Hypurity advance C18 column （50mm × 4.6mm, 5 gm） using a mixture of acetonitrile -5 mM ammonium acetate buffer （pH-4.0） （50：50, v/v） as the mobile phase at a flow rate of 0.8mL/min. The calibration curve obtained was linear （r_〉0.99） over the concentration range of 2.01-400.06 ng/mL for telmisartan and 0.05 -10.01 ng/mL for amlodipine. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.5 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies.
