The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implem...The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.展开更多
During the summer of 2022,a parade of extremes,including heatwaves,droughts,forest fires,and heavy rainfall hit the Sichuan-Chongqing region(SCR),Southwest China(Fig.S1 online),resulting in rippling socioeconomic and ...During the summer of 2022,a parade of extremes,including heatwaves,droughts,forest fires,and heavy rainfall hit the Sichuan-Chongqing region(SCR),Southwest China(Fig.S1 online),resulting in rippling socioeconomic and environmental impacts(Fig.1).Though none of these events are uncommon to the region,their combination in such a daisy-chained fashion is unusual.Here,taking a compound event perspective,we thoroughly reviewed the unfolding of such cascading hazards,and sorted out the pathway of their impacts multiplying.This analysis unmasks previously underestimated and underappreciated vulnerability of multiple critical sectors in the energy-food-water-ecology nexus to increasingly connected extremes.Several key steps are finally outlined with the aim of improving our coping capabilities against impending spatiotemporally compound hazards.展开更多
BACKGROUND The level of Ki-67 expression has served as a prognostic factor in gastric cancer.The quantitative parameters based on the novel dual-layer spectral detector computed tomography(DLSDCT)in discriminating the...BACKGROUND The level of Ki-67 expression has served as a prognostic factor in gastric cancer.The quantitative parameters based on the novel dual-layer spectral detector computed tomography(DLSDCT)in discriminating the Ki-67 expression status are unclear.AIM To investigate the diagnostic ability of DLSDCT-derived parameters for Ki-67 expression status in gastric carcinoma(GC).METHODS Dual-phase enhanced abdominal DLSDCT was performed preoperatively in 108 patients with gastric adenocarcinoma.Primary tumor monoenergetic CT attenuation value at 40-100 kilo electron volt(kev),the slope of the spectral curve(λ_(HU)),iodine concentration(IC),normalized IC(nIC),effective atomic number(Z^(eff))and normalized Z^(eff)(nZ^(eff))in the arterial phase(AP)and venous phase(VP)were retrospectively compared between patients with low and high Ki-67 expression in gastric adenocarcinoma.Spearman’s correlation coefficient was used to analyze the association between the above parameters and Ki-67 expression status.Receiver operating characteristic(ROC)curve analysis was performed to compare the diagnostic efficacy of the statistically significant parameters between two groups.RESULTS Thirty-seven and 71 patients were classified as having low and high Ki-67 expression,respectively.CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),and Z^(eff)-related parameters were significantly higher,but IC-related parameters were lower in the group with low Ki-67 expression status than the group with high Ki-67 expression status,and other analyzed parameters showed no statistical difference between the two groups.Spearman’s correlation analysis showed that CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),Z^(eff),and n Z^(eff) exhibited a negative correlation with Ki-67 status,whereas IC and nIC had positive correlation with Ki-67 status.The ROC analysis demonstrated that the multi-variable model of spectral parameters performed well in identifying the Ki-67 status[area under the curve(AUC)=0.967;sensitivity 95.77%;specificity 91.89%)].Nevertheless,the展开更多
Background,aim,and scope In the context of climate change,extreme precipitation and resulting f looding events are becoming increasingly severe.Remote sensing technologies are advantageous for monitoring such disaster...Background,aim,and scope In the context of climate change,extreme precipitation and resulting f looding events are becoming increasingly severe.Remote sensing technologies are advantageous for monitoring such disasters due to their wide observation range,periodic revisit capabilities,and continuous spatial coverage.These tools enable real-time and quantitative assessment of f lood inundation.Over the past 20 years,the field of remote sensing for f loods has seen significant advancements.Understanding the evolution of research hotspots within this field can offer valuable insights for future research directions.Materials and methods This study systematically analyzes the development and hotspot evolution in the field of f lood remote sensing,both domestically and internationally during 2000—2021.Data from CNKI(China National Knowledge Infrastructure)and WOS(Web of Science)databases are utilized for this analysis.Results(1)A total of 1693 articles have been published in this field,showing a stable growth trend post-2008.Significant contributors include the Chinese Academy of Sciences,Beijing Normal University,Wuhan University,the Italian National Research Council,and National Aeronautics and Space Administration.(2)High-frequency keywords from 2000 to 2021 include“remote sensing”“f lood”“model”“classification”“GIS”“climate change”“area”,and“MODIS”.(3)The most prominent keywords were“GIS”(8.65),“surface water”(7.16),“remote sensing”(7.07),“machine learning”(6.52),and“sentinel-2”(5.86).(4)Thirteen cluster labels were identified through clustering,divided into three phases:2000—2009(initial exploratory stage),2010—2014(period of rapid development),and 2015—2021(steady development of remote sensing for f loods and related disasters).Discussion The field exhibits strong phase-based development,with research focuses shifting over time.From 2000 to 2009,emphasis was on remote sensing image application and f lood model development.From 2010 to 2014,the focus shift展开更多
Thermal insulation materials play an increasingly important role in protecting mechanical parts functioning at high temperatures.In this study,a new porous high-entropy(La_(1/6)Ce_(1/6)Pr_(1/6)Sm_(1/6)Eu_(1/6)Gd_(1/6)...Thermal insulation materials play an increasingly important role in protecting mechanical parts functioning at high temperatures.In this study,a new porous high-entropy(La_(1/6)Ce_(1/6)Pr_(1/6)Sm_(1/6)Eu_(1/6)Gd_(1/6))PO_(4)(HE(6RE_(1/6))PO_(4))ceramics was prepared by combining the high-entropy method with the pore-forming agent method and the effect of different starch contents(0–60vol%)on this ceramic properties was systematically investigated.The results show that the porous HE(6RE_(1/6))PO_(4)ceramics with 60vol%starch exhibit the lowest thermal conductivity of 0.061 W·m^(-1)·K^(-1)at room temperature and good pore structure stability with a linear shrinkage of approximately1.67%.Moreover,the effect of large regular spherical pores(>10μm)on its thermal insulation performance was discussed,and an optimal thermal conductivity prediction model was screened.The superior properties of the prepared porous HE(6RE_(1/6))PO_(4)ceramics allow them to be promising insulation materials in the future.展开更多
Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other tauopathies.Selective elimination of hyperphosphorylated tau is promisin...Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other tauopathies.Selective elimination of hyperphosphorylated tau is promising for the therapy of these diseases.We have conceptualized a strategy,named dephosphorylation-targeting chimeras(DEPTACs),for specifically hijacking phosphatases to tau to debilitate its hyperphosphorylation.Here,we conducted the step-by-step optimization of each constituent motif to generate DEPTACs with reasonable effectiveness in facilitating the dephosphorylation and subsequent clearance of pathological tau.Specifically,for one of the selected chimeras,D16,we demonstrated its significant efficiency in rescuing the neurodegeneration caused by neurotoxic K18-tau seeds in vitro.Moreover,intravenous administration of D16 also alleviated tau pathologies in the brain and improved memory deficits in AD mice.These results suggested DEPTACs as targeted modulators of tau phosphorylation,which hold therapeutic potential for AD and other tauopathies.展开更多
Corrosiveness or scaling is an inherent threat to oil operations. The primary cause for this threat is the presence of water having complex geochemical matrix. Unanticipated water production, particularly if it contai...Corrosiveness or scaling is an inherent threat to oil operations. The primary cause for this threat is the presence of water having complex geochemical matrix. Unanticipated water production, particularly if it contains unwanted impurities, can significantly impact hydrocarbon production. The current paper discusses the degree of threat posed to oil operation facilities based on the water characteristics. Methodology involved the collection and analysis of water samples from major sources in oil industry such as groundwater, wellheads and seawater. The parameters tested include geochemical, microbiological and pollutants. The lab data was used to develop scaling and corrosion prediction indices such as Langelier Saturation Index (LSI), Ryznar Stability Index (RSI) and Puckorius Scaling Index (PSI). The study indicated varying water chemistry for different sources. Mixing of those waters may lead to ionic saturation and scaling in different facilities. Presence of the SRB and GAB in some water sources also posed threat to water system by forming fouling and corrosion. Seawater used for offshore oilfields water injection to maintain reservoir pressure and improve oil recovery showed scaling tendency, whereas under different reservoir pressure, it can cause corrosion. Some of the samples also had corrosion residuals such as iron, which indicated active corrosion. Current study showed higher alkalinity with high sulfate for one groundwater sample with presence of active corrosion residuals such as dissolved iron and manganese. The study showed positive value for LSI which indicated supersaturation of the water samples with respect to calcium carbonate (CaCO<sub>3</sub>) and scale forming. Similarly, for RSI and PSI, the value was below six which confirmed the scaling potential for all the samples. Even though the index value was pointing towards scaling potential, the geochemistry, microbiology and presence of other impurities indicated corrosion threat to the oil and gas industrial facilities. The study concluded th展开更多
Cross-sectional homogenization for full-core calculations of small and complex reactor configurations,such as research reactors,has been recently recognized as an interesting and challenging topic.This paper presents ...Cross-sectional homogenization for full-core calculations of small and complex reactor configurations,such as research reactors,has been recently recognized as an interesting and challenging topic.This paper presents the development of a PARCS/Serpent model for the neutronics analysis of a research reactor type TRIGA Mark-II loaded with Russian VVR-M2 fuel(known as the Dalat Nuclear Research Reactor or DNRR).The full-scale DNRR model and a supercell model for a shim/safety rod and its surrounding fuel bundles with the Monte Carlo code Serpent 2 were proposed to generate homogenized fewgroup cross sections for full-core diffusion calculations with PARCS.The full-scale DNRR model with Serpent 2 was also utilized as a reference to verify the PARCS/Serpent calculations.Comparison of the effective neutron multiplication factors,radial and axial core power distributions,and control rod worths showed a generally good agreement between PARCS and Serpent 2.In addition,the discrepancies between the PARCS and Serpent 2 results are also discussed.Consequently,the results indicate the applicability of the PARCS/Serpent model for further steady state and transient analyses of the DNRR.展开更多
The dendrite growth behavior of high-strength steel during slab continuous casting with a traveling-wave magnetic field was studied in this paper. The morphology of the solidification structure and composition distrib...The dendrite growth behavior of high-strength steel during slab continuous casting with a traveling-wave magnetic field was studied in this paper. The morphology of the solidification structure and composition distribution were analyzed. Results showed that the columnar crystals could deflect and break when the traveling-wave magnetic field had low current intensity. With the increase in current intensity, the secondary dendrite arm spacing and solute permeability decreased, and the columnar crystal transformed into an equiaxed crystal. The electromagnetic force caused by the traveling-wave magnetic field changed the temperature gradient and velocity magnitude and promoted the breaking and fusing of dendrites. Dendrite compactness and composition uniformity were arranged in descending order as follows:columnar-toequiaxed transition (high current intensity), columnar crystal zone (low current intensity), columnar-to-equiaxed transition (low current intensity), and equiaxed crystal zone (high current intensity). Verified numerical simulation results combined with the boundary layer theory of solidification front and dendrite breaking–fusing model revealed the dendrite deflection mechanism and growth process. When thermal stress is not considered, and no narrow segment can be found in the dendrite, the velocity magnitude on the solidification front of liquid steel can reach up to 0.041 m/s before the dendrites break.展开更多
Thirty years ago, the analysis of longwall pillar stability(ALPS) inaugurated a new era in coal pillar design.ALPS was the first empirical pillar design technique to consider the abutment loads that arise from full ex...Thirty years ago, the analysis of longwall pillar stability(ALPS) inaugurated a new era in coal pillar design.ALPS was the first empirical pillar design technique to consider the abutment loads that arise from full extraction, and the first to be calibrated using an extensive database of longwall mining case histories.ALPS was followed by the analysis of retreat mining stability(ARMPS) and the analysis of multiple seam stability(AMSS). These methods incorporated other innovations, including the coal mine roof rating(CMRR), the Mark-Bieniawski pillar strength formula, and the pressure arch loading model. They also built upon ever larger case history databases and employed more sophisticated statistical methods.Today, these empirical methods are used in nearly every underground coal mine in the US. However,the piecemeal manner in which these methods have evolved resulted in some weaknesses. For example,in certain situations, it may not be obvious which program is the best to use. Other times the results from the different programs are not entirely consistent with each other. The programs have also not been updated for several years, and some changes were necessary to keep pace with new developments in mining practice. The analysis of coal pillar stability(ACPS) now integrates all three of the older software packages into a single pillar design framework. ACPS also incorporates the latest research findings in the field of pillar design, including an expanded multiple seam case history data base and a new method to evaluate room and pillar panels containing multiple rows of pillars left in place during pillar recovery.ACPS also includes updated guidance and warnings for users and features upgraded help files and graphics.展开更多
The flow-field index in a 41-ton six-strand tundish is considered through adjusting the ratio of the casting velocity between the strands to eliminate the negative impact of iso-velocity casting in multi-strand tundis...The flow-field index in a 41-ton six-strand tundish is considered through adjusting the ratio of the casting velocity between the strands to eliminate the negative impact of iso-velocity casting in multi-strand tundish on the consistency of each strand due to the large ratio of length to width with narrow shape structure,resulting in poor consistency of each strand.In particular,the response time of strand-1 and strand-6 is relatively long,which affects the uniformity of the temperature field and flow field of the entire tundish.On the basis of verifying that the error between the numerical simulations and hydraulic experiments is less than 6%,six cases with the casting velocity ratio changing from 0.8 to 1.3(with an interval of 0.1)are considered by calculation of numerical models.It is concluded that the consistency of each flow can be obviously improved by increasing the casting velocity ratio between side-strand and middle-strand.With increasing the casting velocity ratio,the flow field in the tundish became much active,the temperature field presented well uniformity,and the tracer concentration distribution in local dead zones was improved.展开更多
Food waste is recognized as a valuable source for potential agricultural applications to supply organic matter and nutrients to arable soil.However,the information on the combined application of food waste and the pla...Food waste is recognized as a valuable source for potential agricultural applications to supply organic matter and nutrients to arable soil.However,the information on the combined application of food waste and the plant growth-promoting bacterial strain,Chlorella,related to plant metabolic features and sodium chloride content in arable soil is limited.The present study was conducted to investigate the exogenous application of food waste along with Chlorella,which improved the physio-morphological features of red pepper.Our results revealed that this combination enhanced the organic matter in the soil,ultimately improving the fertility rate of the soil,and the physio-morphological features,such as chlorophyll a content(24.5±0.7),root(7.8±0.7)cm and shoot length(12.1±0.7)cm,fresh weight(2.1±0.05)g,dry weight(0.19±0.05)g,mineral contents,and hormonal concentration(ABA by up to 2 folds).The combined treatment also minimized free radicals via the activation of the intrinsic antioxidant series cascade and electrolyte leakage.Our findings showed that adding Chlorella and food wastes improved growth characteristics and can be used as a green bio-fertilizer for sustainable agriculture.展开更多
Mold electromagnetic stirring technology for optimizing the flow of molten steel is now widely used in the continuous casting production process of high-quality steels.However,studies on the case that the center of th...Mold electromagnetic stirring technology for optimizing the flow of molten steel is now widely used in the continuous casting production process of high-quality steels.However,studies on the case that the center of the electromagnetic stirrer is located outside the mold have not been reported.Herein,the effect of the electromagnetic stirrer centered outside the mold on the steel flow field was studied in detail by means of numerical simulations.A Gauss meter was used to measure the magnetic induction intensity at different positions,currents,and frequencies.The test results were compared with the simulation results of electromagnetic stirring to calibrate and verify the accuracy of the electromagnetic model.Then,electromagnetic force was introduced into the flow field model as a source term to study its effect on the flow field under anomalous conditions.The results show that when the center of the electromagnetic stirrer is located outside the mold,the magnetic field strength is about twice as strong as that located inside the mold.This also leads to an increase in the flow velocity near the electromagnetic stirrer.As a result,the optimal electromagnetic stirring parameters(200 A,2.5 Hz)were specified when the center of the electromagnetic stirrer is located outside the mold.展开更多
Formation pressure is the key parameter for the analysis of wellbore safety.With increasing drilling depth,how-ever,the behavior of this variable becomes increasingly complex.In this work,a 3D model of the formation p...Formation pressure is the key parameter for the analysis of wellbore safety.With increasing drilling depth,how-ever,the behavior of this variable becomes increasingly complex.In this work,a 3D model of the formation pres-sure under uncertainty is presented.Moreover a relevant algorithm is elaborated.First,the logging data of regional key drilling wells are collected and a one-dimensional formation pressure profile along the well depth is determined.Then,a 3D model of regional formation pressure of the hierarchical group layer is defined by using the Kriging interpolation algorithm relying on a support vector machine(SVM)and the formation pressure of the drilled wells.To validate the method,the formation pressure of one pre-drilled well is compared with the well logging results.The comparison reveals that the maximum relative error is less than 4.5%.The software based on this model is complemented by a computer visualization technology,which provides a relevant tool for under-standing and analyzing the 3D formation pressure.The outcomes of this study are intended to support the char-acterization of areas with missing or poor 3D seismic data and provide more accurate information for the analysis of wellbore integrity.展开更多
Oil and gas industries generate a significant amount of water during the production. The composition of this water varies with the geologic age, depth, and geochemistry of the region along with the chemicals added dur...Oil and gas industries generate a significant amount of water during the production. The composition of this water varies with the geologic age, depth, and geochemistry of the region along with the chemicals added during the process. Geochemistry of formation water is used for aquifer identification, pollution problems, water compatibility studies, corrosion monitoring, water-quality control, water flooding, exploration, and to diagnose wellbore integrity issues. The current study investigates the spatial and temporal variation of produced water geochemistry from one of the largest conventional oil field, Ghawar field, Saudi Arabia. Produced water from different wellheads were collected and analyzed for different geochemical characteristics. Sixteen wells from ABQQ, nineteen wells from ANDR and twenty wells from SDGM area were selected for the current study. Sampling and analysis were performed as per the standard procedures. Results indicated that the pH of the sample varied from 6.0 to 7.4, and Electrical conductivity from 94200 to 102690 μS/cm. The spatial variation of major cations and anions were also recorded and represented by graphical plots. Metal analysis indicated the highest concentration for boron, which is 20.5 mg/L at ABQQ area, whereas all other metals are very low in concentration. Temporal variation of a single well at SDGM area indicated drastic change in the ionic concentration, whereas the geochemistry remains same as indicated by Tickler plot. The water type of the respective area was studied by tickler plots, which indicated same source of formation water in different wells at ABQQ, ANDR and SDGM areas. The ionic concentration is also used to predict corrosion and scaling issues. By Langelier Saturation Index (LSI) and Ryznar Stability Index (RSI), the sample from all the wells showed higher scaling potential. The study concludes that the water type in different areas under Ghawar field remains same regardless of drastic changes in the ionic concentration, which can be used to diagnose wel展开更多
Soil loss through erosion continues to pose serious challenges to increasing the smallholder agricultural productivity in Sierra Leone. While emphasis on sustainable land use practices continue to gain attention among...Soil loss through erosion continues to pose serious challenges to increasing the smallholder agricultural productivity in Sierra Leone. While emphasis on sustainable land use practices continue to gain attention among land users, however, the rate of adoption among smallholder farmers is still very low and hence, in most part of the country soil fertility has been declining at alarming rates. In the Njala area, studies have shown that soil loss ranges from moderate to high. Though soil erosion has been identified as a major soil fertility declining factor, however, the effect of land use practices on the inherent resistance of soil materials to erosion is lacking. This study was therefore conducted to assess the effect of land uses on soil erodibility. The results showed that the soils are coarse sandy loam with high sand content. The dispersion ratios and erosion indices of soils under cassava, plantain, maize and guava were above the minimum thresholds of 15.0 and 10.0 respectively, thus indicating that these soils are highly erodible compared to soils under fallow and sweet potato which have dispersion ratios and erosion indices below the minimum thresholds. Clay content was inversely proportional to and significantly correlated with dispersion ratio and erosion index while the correlations between silt + clay, dispersion ration and erosion index, and silt, silt + clay and dispersion ratio were negative and non-significant. Considering the coarse nature of soils, landscape features and high erodibility indices, these soils would need special soil and water conservation practices to counter further degradation. These may include following, agroforestry, silvi-pasture, controlled and rotational grazing. In addition, awareness of sense of self-responsibility and forest policies and regulations are needed.展开更多
基金The work of A.Jacobsen,C.Evelo,M.Thompson,R.Cornet,R.Kaliyaperuma and M.Roos is supported by funding from the European Union’s Horizon 2020 research and innovation program under the EJP RD COFUND-EJP N°825575.The work of A.Jacobsen,C.Evelo,C.Goble,M.Thompson,N.Juty,R.Hooft,M.Roos,S-A.Sansone,P.McQuilton,P.Rocca-Serra and D.Batista is supported by funding from ELIXIR EXCELERATE,H2020 grant agreement number 676559.R.Hooft was further funded by NL NWO NRGWI.obrug.2018.009.N.Juty and C.Goble were funded by CORBEL(H2020 grant agreement 654248)N.Juty,C.Goble,S-A.Sansone,P.McQuilton,P.Rocca-Serra and D.Batista were funded by FAIRplus(IMI grant agreement 802750)+12 种基金N.Juty,C.Goble,M.Thompson,M.Roos,S-A.Sansone,P.McQuilton,P.Rocca-Serra and D.Batista were funded by EOSClife H2020-EU(grant agreement number 824087)C.Goble was funded by DMMCore(BBSRC BB/M013189/)M.Thompson,M.Roos received funding from NWO(VWData 400.17.605)S-A.Sansone,P.McQuilton,P.Rocca-Serra and D.Batista have been funded by grants awarded to S-A.Sansone from the UK BBSRC and Research Councils(BB/L024101/1,BB/L005069/1)EU(H2020-EU 634107H2020-EU 654241,IMI(IMPRiND 116060)NIH Data Common Fund,and from the Wellcome Trust(ISA-InterMine 212930/Z/18/ZFAIRsharing 208381/A/17/Z)The work of A.Waagmeester has been funded by grant award number GM089820 from the National Institutes of Health.M.Kersloot was funded by the European Regional Development Fund(KVW-00163).The work of N.Meyers was funded by the National Science Foundation(OAC 1839030)The work of M.D.Wilkinson is funded by Isaac Peral/Marie Curie cofund with the Universidad Politecnica de Madrid and the Ministerio de Economia y Competitividad grant number TIN2014-55993-RMThe work of B.Magagna,E.Schultes,L.da Silva Santos and K.Jeffery is funded by the H2020-EU 824068The work of B.Magagna,E.Schultes and L.da Silva Santos is funded by the GO FAIR ISCO grant of the Dutch Ministry of Science and CultureThe work of G.Guizzardi is supported by the OCEAN Project(FUB).M.Courtot received funding from the I
文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.
基金supported by the National Natural Science Foundation of China(42271024)the Science&Technology Development Funding of Chinese Academy of Meteorological Sciences(2023KJ015)。
文摘During the summer of 2022,a parade of extremes,including heatwaves,droughts,forest fires,and heavy rainfall hit the Sichuan-Chongqing region(SCR),Southwest China(Fig.S1 online),resulting in rippling socioeconomic and environmental impacts(Fig.1).Though none of these events are uncommon to the region,their combination in such a daisy-chained fashion is unusual.Here,taking a compound event perspective,we thoroughly reviewed the unfolding of such cascading hazards,and sorted out the pathway of their impacts multiplying.This analysis unmasks previously underestimated and underappreciated vulnerability of multiple critical sectors in the energy-food-water-ecology nexus to increasingly connected extremes.Several key steps are finally outlined with the aim of improving our coping capabilities against impending spatiotemporally compound hazards.
文摘BACKGROUND The level of Ki-67 expression has served as a prognostic factor in gastric cancer.The quantitative parameters based on the novel dual-layer spectral detector computed tomography(DLSDCT)in discriminating the Ki-67 expression status are unclear.AIM To investigate the diagnostic ability of DLSDCT-derived parameters for Ki-67 expression status in gastric carcinoma(GC).METHODS Dual-phase enhanced abdominal DLSDCT was performed preoperatively in 108 patients with gastric adenocarcinoma.Primary tumor monoenergetic CT attenuation value at 40-100 kilo electron volt(kev),the slope of the spectral curve(λ_(HU)),iodine concentration(IC),normalized IC(nIC),effective atomic number(Z^(eff))and normalized Z^(eff)(nZ^(eff))in the arterial phase(AP)and venous phase(VP)were retrospectively compared between patients with low and high Ki-67 expression in gastric adenocarcinoma.Spearman’s correlation coefficient was used to analyze the association between the above parameters and Ki-67 expression status.Receiver operating characteristic(ROC)curve analysis was performed to compare the diagnostic efficacy of the statistically significant parameters between two groups.RESULTS Thirty-seven and 71 patients were classified as having low and high Ki-67 expression,respectively.CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),and Z^(eff)-related parameters were significantly higher,but IC-related parameters were lower in the group with low Ki-67 expression status than the group with high Ki-67 expression status,and other analyzed parameters showed no statistical difference between the two groups.Spearman’s correlation analysis showed that CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),Z^(eff),and n Z^(eff) exhibited a negative correlation with Ki-67 status,whereas IC and nIC had positive correlation with Ki-67 status.The ROC analysis demonstrated that the multi-variable model of spectral parameters performed well in identifying the Ki-67 status[area under the curve(AUC)=0.967;sensitivity 95.77%;specificity 91.89%)].Nevertheless,the
文摘Background,aim,and scope In the context of climate change,extreme precipitation and resulting f looding events are becoming increasingly severe.Remote sensing technologies are advantageous for monitoring such disasters due to their wide observation range,periodic revisit capabilities,and continuous spatial coverage.These tools enable real-time and quantitative assessment of f lood inundation.Over the past 20 years,the field of remote sensing for f loods has seen significant advancements.Understanding the evolution of research hotspots within this field can offer valuable insights for future research directions.Materials and methods This study systematically analyzes the development and hotspot evolution in the field of f lood remote sensing,both domestically and internationally during 2000—2021.Data from CNKI(China National Knowledge Infrastructure)and WOS(Web of Science)databases are utilized for this analysis.Results(1)A total of 1693 articles have been published in this field,showing a stable growth trend post-2008.Significant contributors include the Chinese Academy of Sciences,Beijing Normal University,Wuhan University,the Italian National Research Council,and National Aeronautics and Space Administration.(2)High-frequency keywords from 2000 to 2021 include“remote sensing”“f lood”“model”“classification”“GIS”“climate change”“area”,and“MODIS”.(3)The most prominent keywords were“GIS”(8.65),“surface water”(7.16),“remote sensing”(7.07),“machine learning”(6.52),and“sentinel-2”(5.86).(4)Thirteen cluster labels were identified through clustering,divided into three phases:2000—2009(initial exploratory stage),2010—2014(period of rapid development),and 2015—2021(steady development of remote sensing for f loods and related disasters).Discussion The field exhibits strong phase-based development,with research focuses shifting over time.From 2000 to 2009,emphasis was on remote sensing image application and f lood model development.From 2010 to 2014,the focus shift
基金the National Key R&D Program of China(No.2021YFB3701404)the National Natural Science Fund for Distinguished Young Scholars(No.52025041)+1 种基金the National Natural Science Foundation of China(Nos.52250091,51904021,and 52174294)the Fundamental Research Funds for the Central Universities(Nos.FRF-TP-20-02C2 and FRF-BD-22-05).
文摘Thermal insulation materials play an increasingly important role in protecting mechanical parts functioning at high temperatures.In this study,a new porous high-entropy(La_(1/6)Ce_(1/6)Pr_(1/6)Sm_(1/6)Eu_(1/6)Gd_(1/6))PO_(4)(HE(6RE_(1/6))PO_(4))ceramics was prepared by combining the high-entropy method with the pore-forming agent method and the effect of different starch contents(0–60vol%)on this ceramic properties was systematically investigated.The results show that the porous HE(6RE_(1/6))PO_(4)ceramics with 60vol%starch exhibit the lowest thermal conductivity of 0.061 W·m^(-1)·K^(-1)at room temperature and good pore structure stability with a linear shrinkage of approximately1.67%.Moreover,the effect of large regular spherical pores(>10μm)on its thermal insulation performance was discussed,and an optimal thermal conductivity prediction model was screened.The superior properties of the prepared porous HE(6RE_(1/6))PO_(4)ceramics allow them to be promising insulation materials in the future.
基金co-funded by the Key Project of the National Natural Science Foundation of China [grant number 42230609 and 41630425]the National Key Research and Development Plan projects [grant number 2022YFC3004101]
基金supported by the National Natural Science Foundation of China(82230041,91949205,31730035,81721005)the National Key R&D Program of China(2016YFC1305800)the Guangdong Provincial Key S&T Program(018B030336001)。
文摘Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other tauopathies.Selective elimination of hyperphosphorylated tau is promising for the therapy of these diseases.We have conceptualized a strategy,named dephosphorylation-targeting chimeras(DEPTACs),for specifically hijacking phosphatases to tau to debilitate its hyperphosphorylation.Here,we conducted the step-by-step optimization of each constituent motif to generate DEPTACs with reasonable effectiveness in facilitating the dephosphorylation and subsequent clearance of pathological tau.Specifically,for one of the selected chimeras,D16,we demonstrated its significant efficiency in rescuing the neurodegeneration caused by neurotoxic K18-tau seeds in vitro.Moreover,intravenous administration of D16 also alleviated tau pathologies in the brain and improved memory deficits in AD mice.These results suggested DEPTACs as targeted modulators of tau phosphorylation,which hold therapeutic potential for AD and other tauopathies.
文摘Corrosiveness or scaling is an inherent threat to oil operations. The primary cause for this threat is the presence of water having complex geochemical matrix. Unanticipated water production, particularly if it contains unwanted impurities, can significantly impact hydrocarbon production. The current paper discusses the degree of threat posed to oil operation facilities based on the water characteristics. Methodology involved the collection and analysis of water samples from major sources in oil industry such as groundwater, wellheads and seawater. The parameters tested include geochemical, microbiological and pollutants. The lab data was used to develop scaling and corrosion prediction indices such as Langelier Saturation Index (LSI), Ryznar Stability Index (RSI) and Puckorius Scaling Index (PSI). The study indicated varying water chemistry for different sources. Mixing of those waters may lead to ionic saturation and scaling in different facilities. Presence of the SRB and GAB in some water sources also posed threat to water system by forming fouling and corrosion. Seawater used for offshore oilfields water injection to maintain reservoir pressure and improve oil recovery showed scaling tendency, whereas under different reservoir pressure, it can cause corrosion. Some of the samples also had corrosion residuals such as iron, which indicated active corrosion. Current study showed higher alkalinity with high sulfate for one groundwater sample with presence of active corrosion residuals such as dissolved iron and manganese. The study showed positive value for LSI which indicated supersaturation of the water samples with respect to calcium carbonate (CaCO<sub>3</sub>) and scale forming. Similarly, for RSI and PSI, the value was below six which confirmed the scaling potential for all the samples. Even though the index value was pointing towards scaling potential, the geochemistry, microbiology and presence of other impurities indicated corrosion threat to the oil and gas industrial facilities. The study concluded th
基金the Ministry of Science and Technology of Vietnam(No.DTCB.06/18/VKHKTHN).
文摘Cross-sectional homogenization for full-core calculations of small and complex reactor configurations,such as research reactors,has been recently recognized as an interesting and challenging topic.This paper presents the development of a PARCS/Serpent model for the neutronics analysis of a research reactor type TRIGA Mark-II loaded with Russian VVR-M2 fuel(known as the Dalat Nuclear Research Reactor or DNRR).The full-scale DNRR model and a supercell model for a shim/safety rod and its surrounding fuel bundles with the Monte Carlo code Serpent 2 were proposed to generate homogenized fewgroup cross sections for full-core diffusion calculations with PARCS.The full-scale DNRR model with Serpent 2 was also utilized as a reference to verify the PARCS/Serpent calculations.Comparison of the effective neutron multiplication factors,radial and axial core power distributions,and control rod worths showed a generally good agreement between PARCS and Serpent 2.In addition,the discrepancies between the PARCS and Serpent 2 results are also discussed.Consequently,the results indicate the applicability of the PARCS/Serpent model for further steady state and transient analyses of the DNRR.
基金financially supported by the National Natural Science Foundation of China (No.51774031)。
文摘The dendrite growth behavior of high-strength steel during slab continuous casting with a traveling-wave magnetic field was studied in this paper. The morphology of the solidification structure and composition distribution were analyzed. Results showed that the columnar crystals could deflect and break when the traveling-wave magnetic field had low current intensity. With the increase in current intensity, the secondary dendrite arm spacing and solute permeability decreased, and the columnar crystal transformed into an equiaxed crystal. The electromagnetic force caused by the traveling-wave magnetic field changed the temperature gradient and velocity magnitude and promoted the breaking and fusing of dendrites. Dendrite compactness and composition uniformity were arranged in descending order as follows:columnar-toequiaxed transition (high current intensity), columnar crystal zone (low current intensity), columnar-to-equiaxed transition (low current intensity), and equiaxed crystal zone (high current intensity). Verified numerical simulation results combined with the boundary layer theory of solidification front and dendrite breaking–fusing model revealed the dendrite deflection mechanism and growth process. When thermal stress is not considered, and no narrow segment can be found in the dendrite, the velocity magnitude on the solidification front of liquid steel can reach up to 0.041 m/s before the dendrites break.
文摘Thirty years ago, the analysis of longwall pillar stability(ALPS) inaugurated a new era in coal pillar design.ALPS was the first empirical pillar design technique to consider the abutment loads that arise from full extraction, and the first to be calibrated using an extensive database of longwall mining case histories.ALPS was followed by the analysis of retreat mining stability(ARMPS) and the analysis of multiple seam stability(AMSS). These methods incorporated other innovations, including the coal mine roof rating(CMRR), the Mark-Bieniawski pillar strength formula, and the pressure arch loading model. They also built upon ever larger case history databases and employed more sophisticated statistical methods.Today, these empirical methods are used in nearly every underground coal mine in the US. However,the piecemeal manner in which these methods have evolved resulted in some weaknesses. For example,in certain situations, it may not be obvious which program is the best to use. Other times the results from the different programs are not entirely consistent with each other. The programs have also not been updated for several years, and some changes were necessary to keep pace with new developments in mining practice. The analysis of coal pillar stability(ACPS) now integrates all three of the older software packages into a single pillar design framework. ACPS also incorporates the latest research findings in the field of pillar design, including an expanded multiple seam case history data base and a new method to evaluate room and pillar panels containing multiple rows of pillars left in place during pillar recovery.ACPS also includes updated guidance and warnings for users and features upgraded help files and graphics.
基金supported by the National Natural Science Foundation of China (Grant Number51774031)the State Key Laboratory of Advanced Metallurgy Foundation (Grant Number 41619018)。
文摘The flow-field index in a 41-ton six-strand tundish is considered through adjusting the ratio of the casting velocity between the strands to eliminate the negative impact of iso-velocity casting in multi-strand tundish on the consistency of each strand due to the large ratio of length to width with narrow shape structure,resulting in poor consistency of each strand.In particular,the response time of strand-1 and strand-6 is relatively long,which affects the uniformity of the temperature field and flow field of the entire tundish.On the basis of verifying that the error between the numerical simulations and hydraulic experiments is less than 6%,six cases with the casting velocity ratio changing from 0.8 to 1.3(with an interval of 0.1)are considered by calculation of numerical models.It is concluded that the consistency of each flow can be obviously improved by increasing the casting velocity ratio between side-strand and middle-strand.With increasing the casting velocity ratio,the flow field in the tundish became much active,the temperature field presented well uniformity,and the tracer concentration distribution in local dead zones was improved.
基金supported by the National Research Foundation of Korea(NRF)Grant Funded by the Korean Government(MSIT)(No.2022R1A2C1008993).
文摘Food waste is recognized as a valuable source for potential agricultural applications to supply organic matter and nutrients to arable soil.However,the information on the combined application of food waste and the plant growth-promoting bacterial strain,Chlorella,related to plant metabolic features and sodium chloride content in arable soil is limited.The present study was conducted to investigate the exogenous application of food waste along with Chlorella,which improved the physio-morphological features of red pepper.Our results revealed that this combination enhanced the organic matter in the soil,ultimately improving the fertility rate of the soil,and the physio-morphological features,such as chlorophyll a content(24.5±0.7),root(7.8±0.7)cm and shoot length(12.1±0.7)cm,fresh weight(2.1±0.05)g,dry weight(0.19±0.05)g,mineral contents,and hormonal concentration(ABA by up to 2 folds).The combined treatment also minimized free radicals via the activation of the intrinsic antioxidant series cascade and electrolyte leakage.Our findings showed that adding Chlorella and food wastes improved growth characteristics and can be used as a green bio-fertilizer for sustainable agriculture.
基金The present work was financially supported by the China Postdoctoral Science Foundation(No.2023M730230)Special Funding Projects for Local Science and Technology Development guided by the Central Committee(No.YDZJSX2022C028)Fundamental Research Funds for the Central Universities(No.FRF-TP-22-053A1).
文摘Mold electromagnetic stirring technology for optimizing the flow of molten steel is now widely used in the continuous casting production process of high-quality steels.However,studies on the case that the center of the electromagnetic stirrer is located outside the mold have not been reported.Herein,the effect of the electromagnetic stirrer centered outside the mold on the steel flow field was studied in detail by means of numerical simulations.A Gauss meter was used to measure the magnetic induction intensity at different positions,currents,and frequencies.The test results were compared with the simulation results of electromagnetic stirring to calibrate and verify the accuracy of the electromagnetic model.Then,electromagnetic force was introduced into the flow field model as a source term to study its effect on the flow field under anomalous conditions.The results show that when the center of the electromagnetic stirrer is located outside the mold,the magnetic field strength is about twice as strong as that located inside the mold.This also leads to an increase in the flow velocity near the electromagnetic stirrer.As a result,the optimal electromagnetic stirring parameters(200 A,2.5 Hz)were specified when the center of the electromagnetic stirrer is located outside the mold.
基金supported by Scientific Research and Technology Development Project of CNPC“Study on Exploration and Development Theory and Key Technology of Gulong Shale Oil in Daqing”(2021ZZ10-03)Scientific Research and Technology Development Project of CNPC“Development of Integrated Software(Smart Drilling)for Drilling and Completion Engineering Design and Optimization Decision”(2020B-4019)+1 种基金Scientific Research and Technology Development Project of CNPC“Integration and Experiment of Safe,Optimal and Fast Drilling and Completion Technology for Complex Ultra Deep Wells”(2020F-46)project funded by China Postdoctoral Science Foundation“Research on the Effect of Stress Distribution Difference on Acoustic Propagation Characteristics in Drill String”(2021M693508).
文摘Formation pressure is the key parameter for the analysis of wellbore safety.With increasing drilling depth,how-ever,the behavior of this variable becomes increasingly complex.In this work,a 3D model of the formation pres-sure under uncertainty is presented.Moreover a relevant algorithm is elaborated.First,the logging data of regional key drilling wells are collected and a one-dimensional formation pressure profile along the well depth is determined.Then,a 3D model of regional formation pressure of the hierarchical group layer is defined by using the Kriging interpolation algorithm relying on a support vector machine(SVM)and the formation pressure of the drilled wells.To validate the method,the formation pressure of one pre-drilled well is compared with the well logging results.The comparison reveals that the maximum relative error is less than 4.5%.The software based on this model is complemented by a computer visualization technology,which provides a relevant tool for under-standing and analyzing the 3D formation pressure.The outcomes of this study are intended to support the char-acterization of areas with missing or poor 3D seismic data and provide more accurate information for the analysis of wellbore integrity.
文摘Oil and gas industries generate a significant amount of water during the production. The composition of this water varies with the geologic age, depth, and geochemistry of the region along with the chemicals added during the process. Geochemistry of formation water is used for aquifer identification, pollution problems, water compatibility studies, corrosion monitoring, water-quality control, water flooding, exploration, and to diagnose wellbore integrity issues. The current study investigates the spatial and temporal variation of produced water geochemistry from one of the largest conventional oil field, Ghawar field, Saudi Arabia. Produced water from different wellheads were collected and analyzed for different geochemical characteristics. Sixteen wells from ABQQ, nineteen wells from ANDR and twenty wells from SDGM area were selected for the current study. Sampling and analysis were performed as per the standard procedures. Results indicated that the pH of the sample varied from 6.0 to 7.4, and Electrical conductivity from 94200 to 102690 μS/cm. The spatial variation of major cations and anions were also recorded and represented by graphical plots. Metal analysis indicated the highest concentration for boron, which is 20.5 mg/L at ABQQ area, whereas all other metals are very low in concentration. Temporal variation of a single well at SDGM area indicated drastic change in the ionic concentration, whereas the geochemistry remains same as indicated by Tickler plot. The water type of the respective area was studied by tickler plots, which indicated same source of formation water in different wells at ABQQ, ANDR and SDGM areas. The ionic concentration is also used to predict corrosion and scaling issues. By Langelier Saturation Index (LSI) and Ryznar Stability Index (RSI), the sample from all the wells showed higher scaling potential. The study concludes that the water type in different areas under Ghawar field remains same regardless of drastic changes in the ionic concentration, which can be used to diagnose wel
文摘Soil loss through erosion continues to pose serious challenges to increasing the smallholder agricultural productivity in Sierra Leone. While emphasis on sustainable land use practices continue to gain attention among land users, however, the rate of adoption among smallholder farmers is still very low and hence, in most part of the country soil fertility has been declining at alarming rates. In the Njala area, studies have shown that soil loss ranges from moderate to high. Though soil erosion has been identified as a major soil fertility declining factor, however, the effect of land use practices on the inherent resistance of soil materials to erosion is lacking. This study was therefore conducted to assess the effect of land uses on soil erodibility. The results showed that the soils are coarse sandy loam with high sand content. The dispersion ratios and erosion indices of soils under cassava, plantain, maize and guava were above the minimum thresholds of 15.0 and 10.0 respectively, thus indicating that these soils are highly erodible compared to soils under fallow and sweet potato which have dispersion ratios and erosion indices below the minimum thresholds. Clay content was inversely proportional to and significantly correlated with dispersion ratio and erosion index while the correlations between silt + clay, dispersion ration and erosion index, and silt, silt + clay and dispersion ratio were negative and non-significant. Considering the coarse nature of soils, landscape features and high erodibility indices, these soils would need special soil and water conservation practices to counter further degradation. These may include following, agroforestry, silvi-pasture, controlled and rotational grazing. In addition, awareness of sense of self-responsibility and forest policies and regulations are needed.
