BACKGROUND Recent evidence indicates that malignant ascites may be associated with the high malignancy and poor prognosis of gastric cancer(GC)with peritoneal metastasis(PM),but no robust consensus has been reached un...BACKGROUND Recent evidence indicates that malignant ascites may be associated with the high malignancy and poor prognosis of gastric cancer(GC)with peritoneal metastasis(PM),but no robust consensus has been reached until now.AIM To evaluate the prognostic significance of malignant ascites in GC patients with PM.METHODS Two independent authors conducted database searches.The searches were performed in the EMBASE,PubMed,and Cochrane Library databases,and the terms used to search included stomach neoplasms,GC,ascites,peritoneal effusion,survival,and survival analysis.Outcomes included overall survival and hazard ratios with 95%confidence intervals(CIs).Three pairs of comparisons for measuring survival were made:(1)Patients with ascites vs those without ascites;(2)Patients with massive ascites vs those with mild to moderate ascites;and(3)Patients with massive ascites vs those with no to moderate ascites.RESULTS Fourteen articles including fifteen studies were considered in the final analysis.Among them,nine studies assessed the difference in prognosis between patients with and without malignant ascites.A pooled HR of 1.63(95%CI:1.47-1.82,P<0.00001)indicated that GC patients with malignant ascites had a relatively poor prognosis compared to patients without ascites.We also found that the prognosis of GC patients with malignant ascites was related to the volume of ascites in the six other studies.CONCLUSION GC patients with malignant ascites tend to have a worse prognosis,and the volume of ascites has an impact on GC outcomes.展开更多
With the progression of modern information techniques,such as next generation sequencing(NGS),Internet of Everything(IoE)based smart sensors,and artificial intelligence algorithms,data-intensive research and applicati...With the progression of modern information techniques,such as next generation sequencing(NGS),Internet of Everything(IoE)based smart sensors,and artificial intelligence algorithms,data-intensive research and applications are emerging as the fourth paradigm for scientific discovery.However,we facemany challenges to practical application of this paradigm.In this article,10 challenges to data-intensive discovery and applications in precision medicine and healthcare are summarized and the future perspectives on next generation medicine are discussed.展开更多
DEAR EDITOR,Individual dispersal trends, unquestionably important for species ecology and evolution, are affected by multiple factors. Understanding the factors that influence female dispersal strategies offers import...DEAR EDITOR,Individual dispersal trends, unquestionably important for species ecology and evolution, are affected by multiple factors. Understanding the factors that influence female dispersal strategies offers important insight into primate dispersal mechanisms and female choice. To investigate the proximate causes of dispersal in female Yunnan snub-nosed monkeys (Rhinopithecus bieti), we observed and analyzed nine years of detailed dispersal and demographic data from a population of R. bieti in Xiangguqing, Baimaxueshan Nature Reserve, Yunnan Province, China. Results showed that females who lived long-term in a one-male unit (OMU), without giving birth and with few or no relatives, were more likely to leave that OMU. In addition, an OMU led by an outgroup male and containing more female relatives was significantly more likely to be chosen for immigration. Conversely, greater male age, longer male tenure, and more potentially fertile females discouraged immigration into an OMU. These results suggest that reproduction, male quality, and kin cooperation play the largest roles in female Yunnan snub-nosed monkey dispersal.展开更多
Global Memory Net (GMNet) is intended to be an effective gateway to the world cultural, historical, and heritage image collections from selected academic educational and research partners in the world. Much of these u...Global Memory Net (GMNet) is intended to be an effective gateway to the world cultural, historical, and heritage image collections from selected academic educational and research partners in the world. Much of these unique collections of great value to education and research are not currently accessible due to distance, form, and technical barriers. This project is to find new ways to enable users to access and exploit these significant research collections via global network. As GMNet is ending its first 5-year phase in October 2005, it has contributed substantially to the community building in digital library development by ac- commodating numerous collaborators and technical staff from various parts of the world to spend 3 to 5 months as a full-member of the GMNet team in Boston. They have come from different parts of China—such as Sichuan, Hainan, Shanghai and Xi’an; Croatia; and Hanoi, Vietnam. In addition to contribute to the overall system development and enhancement of system function- alities, they have brought valuable sample image collections of their own institutions/countries, and actually developed prototype collections as a part of GMNet. This paper describes the exciting and productive experience of the first of this visiting research group in developing the GMNet’s Version 2.0 PHP-based system under Prof. Chen’s overall supervision. It also describes both the system’s technical level structure—user/Web-based application/data, and complex functionalities with multi-collection, multi-lingual, multi-modal searching capabilities; system management capabilities; as well as provisions for user uploads and retrieval for our own projects. This Version 2.0 system is built on the Linux/Apache/PHP/MySQL platform. What is described in this paper is an actual case which has formed a base for further new development by others in the research group. It demonstrates fully the value of the synergistic collaboration among global partners for universal digital library development. More information can b展开更多
Combination therapy is a promising approach to address the challenge of antimicrobial resistance,and computational models have been proposed for predicting drug–drug interactions.Most existing models rely on drug sim...Combination therapy is a promising approach to address the challenge of antimicrobial resistance,and computational models have been proposed for predicting drug–drug interactions.Most existing models rely on drug similarity measures based on characteristics such as chemical structure and the mechanism of action.In this study,we focus on the network structure itself and propose a drug similarity measure based on drug–drug interaction networks.We explore the potential applications of this measure by combining it with unsupervised learning and semi-supervised learning approaches.In unsupervised learning,drugs can be grouped based on their interactions,leading to almost monochromatic group–group interactions.In addition,drugs within the same group tend to have similar mechanisms of action(MoA).In semi-supervised learning,the similarity measure can be utilized to construct affinity matrices,enabling the prediction of unknown drug–drug interactions.Our method exceeds existing approaches in terms of performance.Overall,our experiments demonstrate the effectiveness and practicability of the proposed similarity measure.On the one hand,when combined with clustering algorithms,it can be used for functional annotation of compounds with unknown MoA.On the other hand,when combined with semi-supervised graph learning,it enables the prediction of unknown drug–drug interactions.展开更多
OBJECTIVE： To examine the efficacy and safety of short-term and long-term use of antidepres- sants in the treatment of bipolar disorder. DATA SOURCES： A literature search of randomized, double-blind, controlled tria...OBJECTIVE： To examine the efficacy and safety of short-term and long-term use of antidepres- sants in the treatment of bipolar disorder. DATA SOURCES： A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords ＂bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed mania and depression, rapid cycling and bipolar disorder＂, AND ＂antidepressant agent, antidepressive agents second- generation, antidepressive agents tricyclic, monoamine oxidase inhibitor, noradrenaline uptake in- hibitor, serotonin uptake inhibitor, and tricyclic antidepressant agent＂ were used. The studies that were listed in the reference list of the published papers but were not retrieved in the above-mentioned databases were supplemented. STUDY SELECTION： Studies selected were double-blind randomized controlled trials assessing the efficacy and safety of antidepressants in patients with bipolar disorder. All participants were aged 18 years or older, and were diagnosed as having primary bipolar disorder. Antidepressants or antidepressants combined with mood stabilizers were used in experimental interventions. Placebos, mood stabilizers, antipsychotics and other antide pressants were used in the control interventions. Studies that were quasi-randomized studies, or used antidepressants in combination with antipsy- chotics in the experimental group were excluded. All analyses were conducted using Review Man- ager 5.1 provided by the Cochrane Collaboration.展开更多
Quantitatively evaluation of antibacterial activities of inorganic antibacterial agents is an urgent problem to be solved. Using experimental data by an orthogonal design, a prediction model of the relation between co...Quantitatively evaluation of antibacterial activities of inorganic antibacterial agents is an urgent problem to be solved. Using experimental data by an orthogonal design, a prediction model of the relation between conditions of preparing inorganic antibacterial agents and their antibacterial activities has been developed. This is accomplished by introducing BP artificial neural networks in the study of inorganic antibacterial agents. It provides a theoretical support for the development and research on inorganic antibacterial agents. Key words inorganic antibacterial agent - antibacterial activity - neural networks - nanometer material展开更多
The purpose of the present study was to investigate the effect of participation in a health motivation-based intervention program on college students’smoking behavior.One hundred and seventy smokers(mean age=19.0 yea...The purpose of the present study was to investigate the effect of participation in a health motivation-based intervention program on college students’smoking behavior.One hundred and seventy smokers(mean age=19.0 years,151 males)from nine colleges and universities in Chengdu,China were randomly assigned to one of 5 groups that received between one and four sessions of the intervention,or no intervention.The intervention sessions included sequential activities based on the stages of the process model of health motivation.Each group completed questionnaires assessing health motivation and smoking behaviors at pre-test,immediately post-intervention,and at one month follow-up.Analyses indicated that the intervention program did improve participants’health motivation,and that was associated with reduced levels of smoking relative to baseline.The greater the number of sessions,the greater the reduction in smoking.展开更多
Public libraries should be vigilant and responsive to the ever changing information needs of their clientele functioning in a society undergoing through rapid change due to technological innovations. China is currentl...Public libraries should be vigilant and responsive to the ever changing information needs of their clientele functioning in a society undergoing through rapid change due to technological innovations. China is currently experiencing a social and technological transformation of great magnitude in terms of metamorphosing itself from a traditional society to one that is driven by information technologies. Our research study, taking this proposition into account, did a questionnaire survey on 954 library information users at five major public libraries. This research study has discovered that the information needs of public library users today reflect some of the peculiar characteristics of their society in changing times which is driven largely by the rapid development and application of new information technologies. It shows that there is a newly added demand emphasis on certain categories of library resources and services by the Chinese reading public. Our research findings have identified such needs basically in the following five functional areas of public libraries, namely, 1) Increased demands for economic resources, 2) rising expectations for more effective and efficient library services, 3) a convenient location and an amicable environment congenial to learning, 4) a suitable place for engaging in intellectual dialogues and in socialization, and 5) a few other technological amenities and information technology-based digital resources and facilities in addition to a rich repository of library materials in print format. Finally, our paper concludes its discussion with a few observation remarks about the changing trend of public libraries' visions, missions and operations vis-à-vis a contextual background of the ever heightened public expectations for getting quality information services in a timely manner in order for them to function effectively in an information-oriented society such as that of ours today.展开更多
Based on synthetically considering the coupled thermo mechanical relations between temperature and deforming, a numerical simulation of the forging process for the special long cone shaped workpiece of Al 5.44Mg 2...Based on synthetically considering the coupled thermo mechanical relations between temperature and deforming, a numerical simulation of the forging process for the special long cone shaped workpiece of Al 5.44Mg 2.15Li 0.12Zr alloy at high temperature was conducted by using the rigid visco plastic finite element method. The relations between the total load and the displacement during the forging, and the distributions of stress, strain, temperature and strain rate, which can provide useful information for the process design, are obtained.展开更多
It has been widely recognized that academic paper citations will reflect scientific knowledge linkage.Patent citations are similar to academic paper citations in many aspects:Citation frequency distribution is often s...It has been widely recognized that academic paper citations will reflect scientific knowledge linkage.Patent citations are similar to academic paper citations in many aspects:Citation frequency distribution is often skewed; citation frequency varies from one subject field to another and authors' /inventors' preference for citing relevant literature is usually confined to their own native language.However,regardless of these seemingly similarities,the patent citation is unique and special.It is constructed by incorporating information providers from multiple sources,such as from examiners,inventors,attorneys and/or the public.It is driven by a value-orientation for the monopolization of market production under regulations of Patent Laws.It is also practiced under the sway of an industrial culture embedded with a notion of 'creative destruction'.In view of the contextual complexities of patent citations,simply applying the data criteria and citation behavior analysis of academic paper citations to that of patentbibliometrics for the purpose of reflecting knowledge linkage is both conceptually and technically illogical and unreasonable.This paper attempts to delve into the issue of the currently misconceived assertions and practice about 'transplanting' the methodology of academic paper citations en masse indiscriminately into the practice of patent citations.It is hoped that such a study would yield improved result stemming from the practice of patent citations for reflecting knowledge linkage in the future.展开更多
基金Supported by the National Natural Science Foundation of China,No.81672577
文摘BACKGROUND Recent evidence indicates that malignant ascites may be associated with the high malignancy and poor prognosis of gastric cancer(GC)with peritoneal metastasis(PM),but no robust consensus has been reached until now.AIM To evaluate the prognostic significance of malignant ascites in GC patients with PM.METHODS Two independent authors conducted database searches.The searches were performed in the EMBASE,PubMed,and Cochrane Library databases,and the terms used to search included stomach neoplasms,GC,ascites,peritoneal effusion,survival,and survival analysis.Outcomes included overall survival and hazard ratios with 95%confidence intervals(CIs).Three pairs of comparisons for measuring survival were made:(1)Patients with ascites vs those without ascites;(2)Patients with massive ascites vs those with mild to moderate ascites;and(3)Patients with massive ascites vs those with no to moderate ascites.RESULTS Fourteen articles including fifteen studies were considered in the final analysis.Among them,nine studies assessed the difference in prognosis between patients with and without malignant ascites.A pooled HR of 1.63(95%CI:1.47-1.82,P<0.00001)indicated that GC patients with malignant ascites had a relatively poor prognosis compared to patients without ascites.We also found that the prognosis of GC patients with malignant ascites was related to the volume of ascites in the six other studies.CONCLUSION GC patients with malignant ascites tend to have a worse prognosis,and the volume of ascites has an impact on GC outcomes.
基金This work was supported by the regional innovation cooperation between Sichuan and Guangxi Provinces(Grant No.2020YFQ0019)the National Natural Science Foundation of China(Grant No.32070671).
文摘With the progression of modern information techniques,such as next generation sequencing(NGS),Internet of Everything(IoE)based smart sensors,and artificial intelligence algorithms,data-intensive research and applications are emerging as the fourth paradigm for scientific discovery.However,we facemany challenges to practical application of this paradigm.In this article,10 challenges to data-intensive discovery and applications in precision medicine and healthcare are summarized and the future perspectives on next generation medicine are discussed.
基金supported by the National Key Program of Research and Development,Ministry of Science and Technology(2016YFC0503200)National Natural Science Foundation of China(31470461+2 种基金 31700408)Sichuan Youth Science&Technology Foundation(2015JQ0024)Applied Basic Research Program of Sichuan Province(2017JY0325)
文摘DEAR EDITOR,Individual dispersal trends, unquestionably important for species ecology and evolution, are affected by multiple factors. Understanding the factors that influence female dispersal strategies offers important insight into primate dispersal mechanisms and female choice. To investigate the proximate causes of dispersal in female Yunnan snub-nosed monkeys (Rhinopithecus bieti), we observed and analyzed nine years of detailed dispersal and demographic data from a population of R. bieti in Xiangguqing, Baimaxueshan Nature Reserve, Yunnan Province, China. Results showed that females who lived long-term in a one-male unit (OMU), without giving birth and with few or no relatives, were more likely to leave that OMU. In addition, an OMU led by an outgroup male and containing more female relatives was significantly more likely to be chosen for immigration. Conversely, greater male age, longer male tenure, and more potentially fertile females discouraged immigration into an OMU. These results suggest that reproduction, male quality, and kin cooperation play the largest roles in female Yunnan snub-nosed monkey dispersal.
基金supported by the US National Science Foundation/International Digital Library Program(Grant No.NSF/CISE/IIS-9905833).
文摘Global Memory Net (GMNet) is intended to be an effective gateway to the world cultural, historical, and heritage image collections from selected academic educational and research partners in the world. Much of these unique collections of great value to education and research are not currently accessible due to distance, form, and technical barriers. This project is to find new ways to enable users to access and exploit these significant research collections via global network. As GMNet is ending its first 5-year phase in October 2005, it has contributed substantially to the community building in digital library development by ac- commodating numerous collaborators and technical staff from various parts of the world to spend 3 to 5 months as a full-member of the GMNet team in Boston. They have come from different parts of China—such as Sichuan, Hainan, Shanghai and Xi’an; Croatia; and Hanoi, Vietnam. In addition to contribute to the overall system development and enhancement of system function- alities, they have brought valuable sample image collections of their own institutions/countries, and actually developed prototype collections as a part of GMNet. This paper describes the exciting and productive experience of the first of this visiting research group in developing the GMNet’s Version 2.0 PHP-based system under Prof. Chen’s overall supervision. It also describes both the system’s technical level structure—user/Web-based application/data, and complex functionalities with multi-collection, multi-lingual, multi-modal searching capabilities; system management capabilities; as well as provisions for user uploads and retrieval for our own projects. This Version 2.0 system is built on the Linux/Apache/PHP/MySQL platform. What is described in this paper is an actual case which has formed a base for further new development by others in the research group. It demonstrates fully the value of the synergistic collaboration among global partners for universal digital library development. More information can b
基金National Natural Science Foundation of China,Grant/Award Number:62372208,61772226Science and Technology Development Program of Jilin Province,Grant/Award Number:20210204133YY。
文摘Combination therapy is a promising approach to address the challenge of antimicrobial resistance,and computational models have been proposed for predicting drug–drug interactions.Most existing models rely on drug similarity measures based on characteristics such as chemical structure and the mechanism of action.In this study,we focus on the network structure itself and propose a drug similarity measure based on drug–drug interaction networks.We explore the potential applications of this measure by combining it with unsupervised learning and semi-supervised learning approaches.In unsupervised learning,drugs can be grouped based on their interactions,leading to almost monochromatic group–group interactions.In addition,drugs within the same group tend to have similar mechanisms of action(MoA).In semi-supervised learning,the similarity measure can be utilized to construct affinity matrices,enabling the prediction of unknown drug–drug interactions.Our method exceeds existing approaches in terms of performance.Overall,our experiments demonstrate the effectiveness and practicability of the proposed similarity measure.On the one hand,when combined with clustering algorithms,it can be used for functional annotation of compounds with unknown MoA.On the other hand,when combined with semi-supervised graph learning,it enables the prediction of unknown drug–drug interactions.
基金supported in part by the Key Projects of Science and Technology Research of the Department of Education in Henan Province,China,No.13A320869a special fund from Henan Health Science and Technology Innovation Talent Project,No.4173(2010-2015)
文摘OBJECTIVE： To examine the efficacy and safety of short-term and long-term use of antidepres- sants in the treatment of bipolar disorder. DATA SOURCES： A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords ＂bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed mania and depression, rapid cycling and bipolar disorder＂, AND ＂antidepressant agent, antidepressive agents second- generation, antidepressive agents tricyclic, monoamine oxidase inhibitor, noradrenaline uptake in- hibitor, serotonin uptake inhibitor, and tricyclic antidepressant agent＂ were used. The studies that were listed in the reference list of the published papers but were not retrieved in the above-mentioned databases were supplemented. STUDY SELECTION： Studies selected were double-blind randomized controlled trials assessing the efficacy and safety of antidepressants in patients with bipolar disorder. All participants were aged 18 years or older, and were diagnosed as having primary bipolar disorder. Antidepressants or antidepressants combined with mood stabilizers were used in experimental interventions. Placebos, mood stabilizers, antipsychotics and other antide pressants were used in the control interventions. Studies that were quasi-randomized studies, or used antidepressants in combination with antipsy- chotics in the experimental group were excluded. All analyses were conducted using Review Man- ager 5.1 provided by the Cochrane Collaboration.
文摘Quantitatively evaluation of antibacterial activities of inorganic antibacterial agents is an urgent problem to be solved. Using experimental data by an orthogonal design, a prediction model of the relation between conditions of preparing inorganic antibacterial agents and their antibacterial activities has been developed. This is accomplished by introducing BP artificial neural networks in the study of inorganic antibacterial agents. It provides a theoretical support for the development and research on inorganic antibacterial agents. Key words inorganic antibacterial agent - antibacterial activity - neural networks - nanometer material
文摘The purpose of the present study was to investigate the effect of participation in a health motivation-based intervention program on college students’smoking behavior.One hundred and seventy smokers(mean age=19.0 years,151 males)from nine colleges and universities in Chengdu,China were randomly assigned to one of 5 groups that received between one and four sessions of the intervention,or no intervention.The intervention sessions included sequential activities based on the stages of the process model of health motivation.Each group completed questionnaires assessing health motivation and smoking behaviors at pre-test,immediately post-intervention,and at one month follow-up.Analyses indicated that the intervention program did improve participants’health motivation,and that was associated with reduced levels of smoking relative to baseline.The greater the number of sessions,the greater the reduction in smoking.
基金supported by National Planning Office of Philosophy and Social Science of China(GrantNo.06CTQ002)
文摘Public libraries should be vigilant and responsive to the ever changing information needs of their clientele functioning in a society undergoing through rapid change due to technological innovations. China is currently experiencing a social and technological transformation of great magnitude in terms of metamorphosing itself from a traditional society to one that is driven by information technologies. Our research study, taking this proposition into account, did a questionnaire survey on 954 library information users at five major public libraries. This research study has discovered that the information needs of public library users today reflect some of the peculiar characteristics of their society in changing times which is driven largely by the rapid development and application of new information technologies. It shows that there is a newly added demand emphasis on certain categories of library resources and services by the Chinese reading public. Our research findings have identified such needs basically in the following five functional areas of public libraries, namely, 1) Increased demands for economic resources, 2) rising expectations for more effective and efficient library services, 3) a convenient location and an amicable environment congenial to learning, 4) a suitable place for engaging in intellectual dialogues and in socialization, and 5) a few other technological amenities and information technology-based digital resources and facilities in addition to a rich repository of library materials in print format. Finally, our paper concludes its discussion with a few observation remarks about the changing trend of public libraries' visions, missions and operations vis-à-vis a contextual background of the ever heightened public expectations for getting quality information services in a timely manner in order for them to function effectively in an information-oriented society such as that of ours today.
文摘Based on synthetically considering the coupled thermo mechanical relations between temperature and deforming, a numerical simulation of the forging process for the special long cone shaped workpiece of Al 5.44Mg 2.15Li 0.12Zr alloy at high temperature was conducted by using the rigid visco plastic finite element method. The relations between the total load and the displacement during the forging, and the distributions of stress, strain, temperature and strain rate, which can provide useful information for the process design, are obtained.
文摘It has been widely recognized that academic paper citations will reflect scientific knowledge linkage.Patent citations are similar to academic paper citations in many aspects:Citation frequency distribution is often skewed; citation frequency varies from one subject field to another and authors' /inventors' preference for citing relevant literature is usually confined to their own native language.However,regardless of these seemingly similarities,the patent citation is unique and special.It is constructed by incorporating information providers from multiple sources,such as from examiners,inventors,attorneys and/or the public.It is driven by a value-orientation for the monopolization of market production under regulations of Patent Laws.It is also practiced under the sway of an industrial culture embedded with a notion of 'creative destruction'.In view of the contextual complexities of patent citations,simply applying the data criteria and citation behavior analysis of academic paper citations to that of patentbibliometrics for the purpose of reflecting knowledge linkage is both conceptually and technically illogical and unreasonable.This paper attempts to delve into the issue of the currently misconceived assertions and practice about 'transplanting' the methodology of academic paper citations en masse indiscriminately into the practice of patent citations.It is hoped that such a study would yield improved result stemming from the practice of patent citations for reflecting knowledge linkage in the future.
